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Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

It's a good news, bad news story. Patients whose brain tumors have a mutated enzyme called IDH1 typically live longer than those without the mutation.

24 Jan 2023

Novel amyloid protein discovered from canine mammary tumors

A collaboration led by scientists at Tokyo University of Agriculture and Technology (TUAT), Japan, has discovered a novel amyloid protein from canine mammary tumors.

24 Jan 2023

Transcriptomic analysis of placental tissue aids in understanding the pathogenic mechanisms of SARS-CoV-2 in pregnancy at the cellular level

Researchers explored the pathogenic mechanisms of SARS-CoV-2 in pregnancy using digital spatial profiling of placental tissue.

24 Jan 2023

Researchers identify potent pan-sarbecovirus antibodies from non-human primates vaccinated with an AS03 adjuvanted subunit SARS-CoV-2 vaccine

Researchers assessed the effectiveness of pan-sarbecovirus-neutralizing antibodies against SARS-CoV-2.

24 Jan 2023

Transient gut infection influences hosts’ adaptation to nutrient restriction

Transient gut infection not only promotes white adipose tissue expansion and host weight gain but also optimizes host metabolism for carbohydrates.

23 Jan 2023

Dietary plant sugar promotes antitumor immunity and enhances the efficacy of immunotherapy

Immunotherapies have improved outcomes of many patients with cancer, including melanoma. But these therapies work for only a subset of patients.

23 Jan 2023

Consuming soy flour rich in protein B-conglycinin could reduce LDL cholesterol levels

A protein in soybeans blocks the production of a liver enzyme involved in the metabolism of triglycerides and low-density lipoprotein, scientists found in a recent study.

23 Jan 2023

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely understood.

23 Jan 2023

Researchers report a reduction in hospitalizations and deaths from SARS-CoV-2 infections during the Omicron variant-dominated wave in Malawi

Researchers conducted a serosurvey during the SARS-CoV-2 Omicron wave in Malawi.

23 Jan 2023

In silico study suggests SARS-CoV-2 Omicron XBB.1.5 strain to be more infective than previous strains

Researchers performed an in silico analysis to estimate the relative risks of recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.

23 Jan 2023

Healthy gene found in centenarians can reverse the decline of heart performance in older people

An anti-aging gene discovered in a population of centenarians has been shown to rewind the heart's biological age by 10 years.

23 Jan 2023

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced it is supporting a Master’s student at the University of Glasgow (UoG) to undertake a research project on USP30, a DUB implicated in neurodegenerative, renal, and cardiovascular diseases.

From Ubiquigent Limited 23 Jan 2023

Study suggests Alzheimer’s disease diagnosis is associated with higher levels of soluble ACE2 in the human brain

Researchers investigated ACE2 (angiotensin-converting enzyme 2) levels among individuals with AD (Alzheimer’s disease).

23 Jan 2023

Genetic disorder that causes immunodeficiency and susceptibility to opportunistic infections discovered

An international consortium co-led by Vanderbilt University Medical Center immunogeneticist Rubén Martínez-Barricarte, PhD, has discovered a new genetic disorder that causes immunodeficiency and profound susceptibility to opportunistic infections including a life-threatening fungal pneumonia.

23 Jan 2023

Potent small-molecule inhibitors against SARS-CoV, MERS-CoV, and SARS-CoV-2

In a recent study posted to bioRxiv* preprint server, researchers in the United States identified several potent pan-coronavirus (CoV) inhibitors.

23 Jan 2023

SARS-CoV-2 Omicron XBB.1.5, CA.3.1, and CH.1.1 exhibit remarkable antibody resistance

In a recent study posted to bioRxiv* preprint server, researchers at Ohio State University examined the degree of neutralizing antibody (nAb) evasion by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron XBB.1.5, CA.3.1, and CH.1.1 subvariants.

23 Jan 2023

New tool can accurately discover, quantify RNA molecules from error-prone long-read RNA sequencing data

On the journey from gene to protein, a nascent RNA molecule can be cut and joined, or spliced, in different ways before being translated into a protein.

20 Jan 2023

Powerful microscopy tool sheds light on the origins of arterial biomass in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is a rare and incurable disease of the lung arteries that causes early death.

20 Jan 2023

Study sheds light on the mechanisms behind virulence of MRSA blood stream infections

Researchers at Mount Sinai, in collaboration with researchers at New York University, have published a study in Cell Host and Microbe that sheds light on the mechanisms behind the severity, or virulence, of methicillin-resistant Staphylococcus aureus (MRSA) blood stream infections.

20 Jan 2023

Study reveals the mechanism through which Sirtuin 7 protein suppresses thermogenesis in mice

Mammals convert the energy stored in adipose (fat) tissue into heat via a process known as thermogenesis.

20 Jan 2023

Protein C News and Research

Researchers discover the gene responsible for radiation resistance in mutant IDH1 glioma

Novel amyloid protein discovered from canine mammary tumors

Transcriptomic analysis of placental tissue aids in understanding the pathogenic mechanisms of SARS-CoV-2 in pregnancy at the cellular level

Researchers identify potent pan-sarbecovirus antibodies from non-human primates vaccinated with an AS03 adjuvanted subunit SARS-CoV-2 vaccine

Transient gut infection influences hosts’ adaptation to nutrient restriction

Dietary plant sugar promotes antitumor immunity and enhances the efficacy of immunotherapy

Consuming soy flour rich in protein B-conglycinin could reduce LDL cholesterol levels

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

Researchers report a reduction in hospitalizations and deaths from SARS-CoV-2 infections during the Omicron variant-dominated wave in Malawi

In silico study suggests SARS-CoV-2 Omicron XBB.1.5 strain to be more infective than previous strains

Healthy gene found in centenarians can reverse the decline of heart performance in older people

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Study suggests Alzheimer’s disease diagnosis is associated with higher levels of soluble ACE2 in the human brain

Genetic disorder that causes immunodeficiency and susceptibility to opportunistic infections discovered

Potent small-molecule inhibitors against SARS-CoV, MERS-CoV, and SARS-CoV-2

SARS-CoV-2 Omicron XBB.1.5, CA.3.1, and CH.1.1 exhibit remarkable antibody resistance

New tool can accurately discover, quantify RNA molecules from error-prone long-read RNA sequencing data

Powerful microscopy tool sheds light on the origins of arterial biomass in pulmonary arterial hypertension

Study sheds light on the mechanisms behind virulence of MRSA blood stream infections

Study reveals the mechanism through which Sirtuin 7 protein suppresses thermogenesis in mice

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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