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More compounding pharmacies closed as new infections are reported

Massachusetts orders the closing of three more pharmacies, while health officials in at least two states report additional infections from contaminated steroids, although the latest cases are not life-threatening.

7 Dec 2012

Research Roundup: Medicare Advantage Plan beneficiaries may get more appropriate use of services; CHIP participation grows; College students' flu vaccination rates weak

Analysis Of Medicare Advantage HMOs Compared With Traditional Medicare Shows Lower Use of Many Services During 2003-09 – Researchers compared the utilization rates of Medicare Advantage health maintenance organizations (HMOs) with those of traditional Medicare beneficiaries, 2003-09, "to ascertain whether the HMO enrollees demonstrated different levels of use of services, which can be a hallmark of more integrated care."

7 Dec 2012

VA to offer new rules for veterans with brain injuries

The new regulations will make it easier for veterans with traumatic brain injuries to get health care. And, an agreement between the VA and the Indian Health Service will allow some vets to get care closer to home.

7 Dec 2012

CBT may help reduce depression in people who have not responded to antidepressants

For the first time in a large-scale randomised trial, scientists have demonstrated that people with depression who have not responded to treatment with antidepressants are three times more likely to get better if they receive cognitive behavioural therapy (CBT) in addition to antidepressants and usual care.

7 Dec 2012

BMI may influence which blood pressure treatments work best

According to new research published Online First in The Lancet, body mass index (BMI) may influence which blood pressure medications work best at reducing the major complications of high blood pressure (strokes, heart attacks, and death).

7 Dec 2012

Pay for performance may have reduced UK mortality rates

The introduction in 2008 of a US-based “pay-for-performance” scheme into National Health Service hospitals in the northwest of the UK resulted in a significant decrease in mortality rates, particularly for pneumonia, study findings show.

7 Dec 2012

Noncoding DNA sequence required for epidermal differentiation

The differentiation of human epidermis is controlled and stabilized by a long noncoding RNA termed terminal differentiation-induced noncoding RNA acting through a post-transcriptional mechanism, the results of an innovative US study indicate.

7 Dec 2012

Pesticides in tap water may increase food allergy risk

Having a high level of urinary dichlorophenols is associated with the presence of food sensitization and allergies, say researchers.

7 Dec 2012

Scientists identify underlying genetic cause for rare motor neurone disorder

Scientists have identified an underlying genetic cause for a rare disorder of motor neurones, and believe this may help find causes of other related diseases.

7 Dec 2012

First Edition: December 7, 2012

Today's early morning highlights from the major news organizations includes articles on the talks between President Barack Obama and House Speaker John Boehner on the "fiscal cliff."

7 Dec 2012

Genomic sequencing reveals therapeutic drug targets for metastatic triple-negative breast cancer

Genomic sequencing has revealed therapeutic drug targets for difficult-to-treat, metastatic triple-negative breast cancer (TNBC), according to an unprecedented study by the Translational Genomic Research Institute (TGen) and US Oncology Research.

7 Dec 2012

Disturbances in several immune-system-related pathways contribute to development of ASDs

Researchers using novel approaches and methodologies of identifying genes that contribute to the development of autism have found evidence that disturbances in several immune-system-related pathways contribute to development of autism spectrum disorders.

7 Dec 2012

Researchers discover 29 proteins associated with spread of kidney cancer

Researchers at St. Michael's hospital have identified 29 proteins that are likely to be involved in the spread of kidney cancer. The discovery will help physicians recognize which tumours are going to behave more aggressively and provide those patients with more intensive treatment and closer followup.

7 Dec 2012

Genome sequencing reveals previously unreported mutations in metastatic TNBC

Whole genome sequencing has revealed previously unreported mutations in metastatic triple-negative breast cancer (TNBC), according to a study published by the journal Molecular Cancer Therapeutics.

6 Dec 2012

Study finds relationships between body size and epigenetic changes

New research in human volunteers has shown that molecular changes to our genes, known as epigenetic marks, are driven mainly by ageing but are also affected by what we eat.

6 Dec 2012

SOX2 directly regulated by tumor suppressor CDKN1B(p27) gene

A team of researchers from the Spanish National Cancer Research Centre (CNIO), led by Manuel Serrano, from the Tumour Suppression Group, together with scientists from London and Santiago de Compostela, has discovered that the cellular reprogramming gene SOX2, which is involved in several types of cancers, such as lung cancer and pituitary cancer, is directly regulated by the tumor suppressor CDKN1B(p27) gene, which is also associated with these types of cancer.

6 Dec 2012

Prenatal stress linked to affective disorders in offspring

Individuals born to women who experience major stress during early pregnancy are at increased risk for developing affective disorders, study results suggest.

6 Dec 2012

Case Western Reserve to receive funding through Healthy Growth grant program

Case Western Reserve University School of Medicine announced that it will receive funding through the Achieving Healthy Growth program within the Grand Challenges in Global Health initiative.

6 Dec 2012

Synthetic marijuana linked to 11,406 of 4.9M drug-related ED visits in 2010

Street forms of synthetic cannabinoids - so-called "synthetic marijuana" - were linked to 11,406 of the 4.9 million drug-related emergency department (ED) visits in 2010, according to a new report by the Substance Abuse and Mental Health Services Administration (SAMHSA).

6 Dec 2012

Scientists develop MitoFish for in vivo studies of mitochondria transport in nerve cells

Scientists have demonstrated a new way to investigate mechanisms at work in Alzheimer's and other neurodegenerative diseases, which also could prove useful in the search for effective drugs. For new insights, they turned to the zebrafish, which is transparent in the early stages of its life. The researchers developed a transgenic variety, the "MitoFish," that enables them to see - within individual neurons of living animals - how brain diseases disturb the transport of mitochondria, the power plants of the cell.

6 Dec 2012