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Broken String Biosciences’ INDUCE-seq platform demonstrates impact of structural DNA changes on specificity of CRISPR-Cas9 gene editing

Broken String Biosciences today announced that its INDUCE-seq™ DNA break-mapping technology had been used in a peer-reviewed research paper to characterize off-target effects of CRISPR-Cas9 gene editing resulting from changes in DNA topology.

From Broken String Biosciences 31 Oct 2023

New study identifies regional hotspots for Parkinson's disease

A new study led by researchers at Barrow Neurological Institute has found that people living in regions with median levels of air pollution have a 56 percent greater risk of developing Parkinson's disease compared to those living in regions with the lowest level of air pollution.

30 Oct 2023

Promising new drug target for triple-negative breast cancer identified

Improving treatments for triple-negative breast cancer (TNBC), an aggressive tumor with very poor prognosis and limited therapeutic targets, has been challenging.

30 Oct 2023

Modular nanoparticles developed for targeted drug delivery and neutralizing biological agents

Engineers at the University of California San Diego have developed modular nanoparticles that can be easily customized to target different biological entities such as tumors, viruses or toxins.

30 Oct 2023

New MECP2 gene variant identified and characterized in Rett syndrome

Rett syndrome is a rare devastating neurological disorder that primarily affects young girls and manifests as an impaired ability to walk and talk, along with characteristic 'hand-wringing' movements, seizures, and cognitive disability.

30 Oct 2023

Scientists identify mechanism of alcohol withdrawal headaches

About 283 million people worldwide suffer from alcohol use disorder, a debilitating health challenge for which limited therapeutic options are available. The cost to society is estimated at greater than $2 trillion annually.

30 Oct 2023

UTA bioengineer receives NIH grant to develop high-resolution imaging system to quantify cell tracking

The ability to dynamically track the movement of cells is essential for modeling cellular interactions as they form organs such as the heart. But current microscope technology isn't up to the task of capturing those movements.

30 Oct 2023

Self-supervised learning models generate brain-like activity patterns

To make our way through the world, our brain must develop an intuitive understanding of the physical world around us, which we then use to interpret sensory information coming into the brain.

30 Oct 2023

Study unveils new approach to more precise, long-lasting, and less toxic cancer treatment

For too long, cancer treatment has been a double-edged sword – the very treatments designed to kill cancer cells often wrought havoc on healthy ones too.

30 Oct 2023

New antibody may offer effective drug treatment for breast cancer

An enzyme that may help some breast cancers spread can be stopped with an antibody created in the lab of Cold Spring Harbor Laboratory Professor Nicholas Tonks.

30 Oct 2023

Short-chain fatty acids produced by intestinal bacteria play role in dendritic cell elongation

Dendritic cells play a key role in the mammalian immune system. These cells are present throughout the human body and are known to capture foreign bodies, i.e., antigens, using extendable "arms" called dendrites.

30 Oct 2023

Study uncovers interplay of lifestyle choices and DNA methylation in gastric neoplasia risk

A new paper in The Lancet eBioMedicine explores whether these changes predict the future risk of stomach tumors and how epigenetic changes interact with environmental and lifestyle factors in this process.

30 Oct 2023

How does the Mediterranean diet impact insulin resistance and sensitivity in obese individuals?

Researchers evaluate the associations between adherence to the Mediterranean diet, insulin secretion, resistance, and sensitivity in obese individuals.

30 Oct 2023

New blood test revolutionizes early cancer detection in Li-Fraumeni Syndrome patients

Canadian researchers develop a cell-free DNA-based multimodal assay for early cancer detection in patients with Li-Fraumeni Syndrome, a high-cancer-risk condition. The assay outperforms conventional methods, promising more sensitive and less invasive cancer surveillance.

29 Oct 2023

Plant-based materials will be the building blocks for soft medical microrobots

A team of University of Waterloo researchers has created smart, advanced materials that will be the building blocks for a future generation of soft medical microrobots.

28 Oct 2023

MHRA grants conditional marketing authorization for AbbVie's Tepkinly to treat aggressive blood cancer

AbbVie today announced that the UK Medicines and Healthcare products Regulatory Agency has granted conditional Marketing Authorisation for Tepkinly® (epcoritamab) as a monotherapy for the treatment of adults with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL), after two or more systemic therapies.

28 Oct 2023

B Cell News and Research

Broken String Biosciences’ INDUCE-seq platform demonstrates impact of structural DNA changes on specificity of CRISPR-Cas9 gene editing

New study identifies regional hotspots for Parkinson's disease

Promising new drug target for triple-negative breast cancer identified

Modular nanoparticles developed for targeted drug delivery and neutralizing biological agents

New MECP2 gene variant identified and characterized in Rett syndrome

Scientists identify mechanism of alcohol withdrawal headaches

UTA bioengineer receives NIH grant to develop high-resolution imaging system to quantify cell tracking

Self-supervised learning models generate brain-like activity patterns

Study unveils new approach to more precise, long-lasting, and less toxic cancer treatment

New antibody may offer effective drug treatment for breast cancer

Short-chain fatty acids produced by intestinal bacteria play role in dendritic cell elongation

Study uncovers interplay of lifestyle choices and DNA methylation in gastric neoplasia risk

How does the Mediterranean diet impact insulin resistance and sensitivity in obese individuals?

New blood test revolutionizes early cancer detection in Li-Fraumeni Syndrome patients

Plant-based materials will be the building blocks for soft medical microrobots

MHRA grants conditional marketing authorization for AbbVie's Tepkinly to treat aggressive blood cancer

Cuproptosis subtypes and immune infiltration provide insights into prognosis of hepatocellular carcinoma

Eppendorf & Science Prize for Neurobiology awarded to Marissa Scavuzzo for glial cell research

Imperial researchers discover hidden mechanism behind feeling touch

Low-cost anti-inflammatory hydrogel could help treat chronic skin lesions in people with diabetes

Industry focus eBook - Cell and gene therapy (2nd edition) eBook

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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