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Research shows how adipose tissue reduces efficiency of radiotherapy in breast cancer patients

According to research published online in The FASEB Journal, repeated irradiation of breast fat (also known as adipose tissue) produces an inflammatory response that ultimately reduces the efficiency of radiotherapy in breast cancer patients.

8 Jun 2017

New florescent imaging technique tracks actions of key enzymes in cancer, kidney disease

Researchers at the Universities of York and Leiden have pioneered a technique which uses florescent imaging to track the actions of key enzymes in cancer, genetic disorders and kidney disease.

8 Jun 2017

Natural sugar may trigger immune system to treat atherosclerosis, study finds

Researchers have long sought ways to harness the body's immune system to treat disease, especially cancer.

7 Jun 2017

Molecular biologists identify enzyme that activates and ‘supercharges’ cellular machinery

St. Jude Children's Research Hospital molecular biologists have identified an enzyme that activates and "supercharges" cellular machinery that controls how cells become specialized cells in the body.

7 Jun 2017

Drinking few cups of coffee or tea may protect against liver fibrosis, study finds

Chronic liver diseases rank as the 12th cause of death worldwide and many of these disorders are associated with unhealthy lifestyles. Conversely, a healthier lifestyle can help prevent or reverse liver disease.

6 Jun 2017

Diabetes medication can protect against cardiac stiffening in obese female mice

Overconsumption of a Western diet high in fats and refined sugars has contributed to a global increase in obesity and Type 2 diabetes.

6 Jun 2017

Findings point to potential new treatment for people with newly diagnosed EGFR-positive NSCLC

Findings from a phase III clinical trial point to a potential new treatment for patients newly diagnosed with advanced, epidermal growth factor receptor (EGFR)-positive non-small cell lung cancer (NSCLC).

5 Jun 2017

Positive results for AstraZeneca’s PARP inhibitor Lynparza in advanced breast cancer

A new study has shown that AstraZeneca's Lynparza (olaparib) can significantly slow the progress of breast cancer that is caused partially due to mutations of the culprit gene called BRCA. BRCA gene mutations are responsible for around 3% of all breast cancers. These cases of the disease that have a basis in the gene are notoriously difficult to treat and women who are tested positive for this gene may even opt for removal of their breasts before even the cancer strikes. Noted actress Angelina Jolie went for a similar prophylactic mastectomy.

5 Jun 2017

Standard therapy plus abiraterone lowers relative risk of death in men with advanced prostate cancer

A clinical trial of nearly 2,000 men shows that adding abiraterone acetate (Zytiga) to a standard initial treatment regimen for high-risk, advanced prostate cancer lowers the relative risk of death by 37%.

5 Jun 2017

Patients nearing end of life may not feel abandoned after discontinuation of cholesterol medications

New research suggests patients nearing the end of their lives because of a "life-limiting illness" such as cancer or heart disease may not feel medically abandoned if their doctor wants to take them off the statins that control their cholesterol.

2 Jun 2017

Scientists locate crucial off-switch for central cell control

As the cell's molecular control center, the mTor kinase regulates cellular metabolism, growth and division. However, in cells affected by pathological change, the regulation goes array.

2 Jun 2017

Bacterial cell factories produce enzymes that can be used as active ingredients in drugs

Researchers at the Novo Nordisk Foundation Center for Biosustainability in Denmark have developed a method of producing P450 enzymes - used by plants to defend against predators and microbes - in bacterial cell factories. The process could facilitate the production of large quantities of the enzymes, which are also involved in the biosynthesis of active ingredients of cancer drugs.

2 Jun 2017

Researchers discover new class of compounds that inhibit bacterial DNA gyrase

An international team of scientists have discovered a new class of compounds that inhibit bacterial DNA gyrase.

1 Jun 2017

Key metabolic enzyme fuels molecular machinery to turn on memory genes after learning

Understanding how memories are made, retrieved, and eventually fade over a lifetime is the stuff of poems and song. To medical researchers, solving the mysteries of memory is even more elusive.

1 Jun 2017

Experimental drug increases progression-free survival in pancreatic cancer patients, clinical trial shows

By adding an experimental drug to a standard chemotherapy regimen, a subset of patients with metastatic pancreatic cancer had a significantly longer period before the cancer progressed as compared with those who received the standard treatment, according to a Phase 2 clinical trial led by an investigator at Fred Hutchinson Cancer Research Center.

1 Jun 2017

Collaborative effort to develop rare disease patient registries

The Orphan Disease Center in the Perelman School of Medicine at the University of Pennsylvania will collaborate with Pulse Infoframe Inc., a medical informatics company, to develop rare disease patient registries aimed at enabling international collaboration to better understand these diseases, as well as accelerate and improve clinical studies to develop new therapies.

31 May 2017

Enzyme News and Research

Research shows how adipose tissue reduces efficiency of radiotherapy in breast cancer patients

New florescent imaging technique tracks actions of key enzymes in cancer, kidney disease

Natural sugar may trigger immune system to treat atherosclerosis, study finds

Molecular biologists identify enzyme that activates and ‘supercharges’ cellular machinery

Drinking few cups of coffee or tea may protect against liver fibrosis, study finds

Diabetes medication can protect against cardiac stiffening in obese female mice

Findings point to potential new treatment for people with newly diagnosed EGFR-positive NSCLC

Positive results for AstraZeneca’s PARP inhibitor Lynparza in advanced breast cancer

Standard therapy plus abiraterone lowers relative risk of death in men with advanced prostate cancer

Patients nearing end of life may not feel abandoned after discontinuation of cholesterol medications

Scientists locate crucial off-switch for central cell control

Bacterial cell factories produce enzymes that can be used as active ingredients in drugs

Researchers discover new class of compounds that inhibit bacterial DNA gyrase

Key metabolic enzyme fuels molecular machinery to turn on memory genes after learning

Experimental drug increases progression-free survival in pancreatic cancer patients, clinical trial shows

Collaborative effort to develop rare disease patient registries

Cancer treatment may be effective therapy for psoriasis

Investigational compound inhibits cancer-specific mutations in mice

JGU chemists develop technique that reduces toxic effects of cigarettes

Gene editing technology can introduce hundreds of unintended mutations, study shows

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