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Temple research paves the way for first Phase 1/2 clinical trials of CRISPR-based therapy for HIV

For the last seven years, researchers at the Lewis Katz School of Medicine at Temple University have been developing and refining CRISPR-based gene-editing technology for the treatment of human immunodeficiency virus type 1 (HIV) infection.

17 Sep 2021

Discovery of biological response platform could provide opportunity to alleviate allergic inflammation

New discoveries about a built-in rapid reaction system that triggers inflammatory responses when people are exposed to allergens, such as insects, mites, and fungi, also may hold the keys to helping more people manage their allergies in years to come.

17 Sep 2021

Study points to a possible new approach for treating MRSA superbug

A study released in STEM CELLS Translational Medicine, by researchers at the Baker Institute for Animal Health, part of Cornell University's College of Veterinary Medicine, Ithaca, N.Y., details in a relevant ex vivo model how treating wounds with the secretion of a type of stem cell called mesenchymal stromal cell (MSC) effectively reduced methicillin-resistant Staphylococcus aureus – better known as MRSA viability and stimulated the surrounding skin cells to build up a defense against the bacterial invader.

16 Sep 2021

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

The mortality rate of COVID-19 patients requiring mechanical ventilation is 30-40%, however, the immunological factors associated with death in critically ill COVID-19 patients are poorly understood.

16 Sep 2021

New discovery elucidates the link between inflammation and pancreatic cancer development

A new discovery from researchers at The University of Texas MD Anderson Cancer Center has clarified the long-established connection between inflammation and pancreatic cancer development.

16 Sep 2021

Unique imaging technique sheds light on how cells related to IBD affect intestinal tissues

New "maps" of hundreds of thousands of cells related to inflammatory bowel disease shed greater light on their effects on intestinal tissues through a newly utilized imaging technique called "imaging mass cytometry."

16 Sep 2021

Pfizer vaccine induces strong immunity in elderly with prior COVID-19

A new study discusses the vaccination response in elderly who were vaccinated with one dose of the Pfizer vaccine 15 months after contracting COVID-19.

16 Sep 2021

New review highlights several opportunities for improving ginsenoside production

Ginseng, a widely popular superfood, has long been used in traditional medicine. The health benefits of ginseng are largely attributed to compounds called ginsenosides, which are present in the roots, stems, and leaves of the plant. Ginsenosides are known to prevent inflammation, diabetes, and cancer, and can also help control blood cholesterol levels and reduce aging.

16 Sep 2021

COVID-19 and the gut-lung axis

A new study explores the hypothesis that stimulation of the gut could be responsible for the lung inflammation seen in COVID-19, triggered by SARS-CoV-2.

16 Sep 2021

IL-1-Ra autoantibodies observed in high frequency in children with PIMS/MIS-C

Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection typically affects children only mildly, multisystem inflammatory syndrome in children (MIS-C) or pediatric inflammatory multisystem syndrome (PIMS) is a serious but rare complication occurring after infection.

16 Sep 2021

Study identifies probable cause of Alzheimer’s disease

Ground-breaking new Curtin University-led research has discovered a likely cause of Alzheimer's disease, in a significant finding that offers potential new prevention and treatment opportunities for Australia's second-leading cause of death.

16 Sep 2021

Research reveals vital role of protein-coding gene in tumor development and immune therapy response

Researchers from the Case Comprehensive Cancer Center uncovered the potentially important role of the protein-coding gene, MYO10, in tumor development and immune therapy response. Their findings were published today in Science Advances.

16 Sep 2021

Heart inflammation more common among men following mRNA-based COVID-19 vaccination

Researchers in the UK have assessed data from around the world to better understand the frequency and risk factors for myocarditis and pericarditis following immunization with messenger RNA (mRNA)-based vaccines designed to protect against coronavirus disease 2019 (COVID-19).

16 Sep 2021

Flavonoids can potentially help prevent COVID-19-induced diarrhea, study finds

A recent study published in Tropical Biomedicine determines whether flavonoids can help prevent diarrhea caused by SARS-CoV-2 infection.

15 Sep 2021

Deep profiling of SARS-CoV-2 immune response amongst the mildly symptomatic

In a research paper recently uploaded to the medRxiv* preprint server by Capelle et al. (September 2nd, 2021), the immune response of mild and hospitalized COVID-19 patients is compared, finding that early T-cell response is a vital indicator of SARS-CoV-2 disease severity.

15 Sep 2021

SARS-CoV-2 can cause sustained biochemical dysregulation that results in long-COVID

This state has come to be known as long-COVID, and in a paper recently uploaded to the preprint server medRxiv* by Simjanoska et al. (September 7th, 2021) the biochemical parameters of long-COVID patients with prior mild, moderate, or severe COVID-19 that resulted in hospitalization are tracked in detail, finding a characteristically dysregulated immune and inflammatory response in the most seriously ill.

15 Sep 2021

Inflammation News and Research

Temple research paves the way for first Phase 1/2 clinical trials of CRISPR-based therapy for HIV

Discovery of biological response platform could provide opportunity to alleviate allergic inflammation

Study points to a possible new approach for treating MRSA superbug

Fatal COVID-19 infections linked to poor immune responses and elevated MAIT cell activation

New discovery elucidates the link between inflammation and pancreatic cancer development

Unique imaging technique sheds light on how cells related to IBD affect intestinal tissues

Pfizer vaccine induces strong immunity in elderly with prior COVID-19

New review highlights several opportunities for improving ginsenoside production

COVID-19 and the gut-lung axis

IL-1-Ra autoantibodies observed in high frequency in children with PIMS/MIS-C

Study identifies probable cause of Alzheimer’s disease

Research reveals vital role of protein-coding gene in tumor development and immune therapy response

Heart inflammation more common among men following mRNA-based COVID-19 vaccination

Flavonoids can potentially help prevent COVID-19-induced diarrhea, study finds

Deep profiling of SARS-CoV-2 immune response amongst the mildly symptomatic

SARS-CoV-2 can cause sustained biochemical dysregulation that results in long-COVID

Liver may play a key role in the onset or progression of Alzheimer's disease

Flu shots and COVID-19 immunity

Gut microbiome profile could help predict patient's rheumatoid arthritis prognosis

Researchers explore whether cocoa supplementation can reduce aging

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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