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Scientists study cell’s reaction to Salmonella by visualizing protein chains at near-molecular level

With drug resistance being on the rise worldwide, bacterial infections pose one of the greatest global threats to human health. By deciphering the host-pathogen interaction on a molecular level, researchers hope to pave the way for new therapies.

10 May 2017

Study reveals role of good-guy protein in initiating and maintaining cancer

Under normal conditions, the CHD4 protein is one of the good guys: it stops cells from transcribing faulty DNA, thereby eliminating potential mutation. But in colon cancer and perhaps other kinds of cancer as well, it appears that this protein becomes a kind of double agent, working for the enemy.

9 May 2017

Study findings suggest how progranulin deficiency causes frontotemporal dementia

In a recent study in Human Molecular Genetics, researchers from VIB and KU Leuven led by prof. Philip Van Damme, reveal a novel function for progranulin in lysosomes: it acts as chaperone of the lysosomal protease cathepsin D. The results were obtained in collaboration with Prof. Paul Saftig from the University of Kiel.

8 May 2017

Study uncovers potential new therapeutic targets for HCV infections

An international study led by researchers at Monash University' Biomedicine Discovery Institute (BDI) has shone light on the way the Hepatitis C Virus (HCV) hijacks the communication systems in the host cells it infects, uncovering potential new therapeutic targets for the disease.

8 May 2017

Enzyme supplement can potentially reduce uncomfortable symptoms in gluten-sensitive patients

Researchers have found that taking an enzyme tablet while consuming foods containing gluten prevents a significant amount of it from entering the small intestine.

8 May 2017

Scientists identify RIOK1 enzyme as new target for cancer therapy

Dr. Florian Weinberg, from Prof. Dr. Tilman Brummer's research group at the Institute of Molecular Medicine and Cell Research of the University of Freiburg, joined forces with scientists from the Departments of Clinical Pathology and Medicine I of the University Medical Centre Freiburg and the Kinghorn Cancer Centre/Garvan Insitute in Australia in an international team that has identified a new target for cancer therapy.

5 May 2017

Researchers find new way to make influenza visible to the naked eye

Researchers at the University of Notre Dame have discovered a way to make influenza visible to the naked eye, according to a new study in the Journal of the American Chemical Society.

5 May 2017

$New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds$

New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds

A team of researchers of the University of Barcelona and the Hospital del Mar Medical Research Institute have discovered a new mutation that has an impact on the bone so that it is vulnerable to the bisphosphonate, a drug used to treat osteoporosis.

4 May 2017

Research findings reveal new approach to prevent age-related obesity

The function and distribution of adipose tissue in the body change during the course of life. Beige fat cells, a special type of adipocytes, have the capability to use energy reserves - fatty deposits - by generating heat in a process known as thermogenesis.

4 May 2017

Researchers uncover new mechanism that explains cause of portal hypertension

Investigators at the Medical University of South Carolina have identified a critical regulatory mechanism for the production of nitric oxide. Endothelial nitric oxide synthase is the enzyme responsible for the production of NO and its activity is tightly controlled in liver endothelial cells via a series of complex molecular mechanisms; however, in liver injury, eNOS activity, and subsequently NO production, is dysregulated.

3 May 2017

Knocking out lipid-modifying enzyme can boost post-heart attack healing, study shows

Two immune responses are important for recovery after a heart attack - an acute inflammatory response that attracts leukocyte immune cells to remove dead tissue, followed by a resolving response that allows healing.

2 May 2017

Researchers uncover molecule that may explain smoking-CHD connection

Cigarette smoking accounts for about one-fifth of cases of coronary heart disease, one of the leading causes of death worldwide, but precisely how smoking leads to CHD has long been unclear.

2 May 2017

TACC's supercomputers assist in discovery of new, better chemotherapy drugs

Surgery and radiation remove, kill, or damage cancer cells in a certain area. But chemotherapy -- which uses medicines or drugs to treat cancer -- can work throughout the whole body, killing cancer cells that have spread far from the original tumor.

2 May 2017

MDI Biological Laboratory investigator awarded NIH grant for research on peripheral neuropathy

The MDI Biological Laboratory has announced that Sandra Rieger, Ph.D., has been awarded a highly competitive grant from the National Cancer Institute, an institute of the National Institutes of Health, to study the molecular mechanisms underlying chemotherapy-induced peripheral neuropathy, a side effect of cancer chemotherapy causing symptoms such as pain, tingling, temperature sensitivity and numbness in the extremities.

29 Apr 2017

German scientists unravel defense strategy of mushrooms against insect larvae

Some mushrooms produce long-chain unsaturated carboxylic acids as their chemical defense against insect larvae. The biosynthesis of these polyenes relies on only one enzyme, as German scientists have now discovered.

29 Apr 2017

Learning key 'danger zones' can help plastic surgeons to enhance safety of facial filler procedures

Dermal fillers have become a popular alternative to surgery for patients who want a younger facial appearance. Learning about some key "danger zones" can help plastic surgeons to enhance the safety and effectiveness of facial filler procedures, according to an expert update in the May issue of Plastic and Reconstructive Surgery, the official medical journal of the American Society of Plastic Surgeons.

29 Apr 2017

Takeda announces accelerated approval from FDA for new lung cancer treatment

Takeda Pharmaceutical Company Limited (TSE: 4502) today announced that ALUNBRIG (brigatinib) has received Accelerated Approval from the U.S. Food and Drug Administration for the treatment of patients with anaplastic lymphoma kinase-positive (ALK+) metastatic non-small cell lung cancer who have progressed on or are intolerant to crizotinib.

28 Apr 2017

VUMC researcher receives grant to test efficacy of drug for reversing precancerous stomach lesions

Vanderbilt University Medical Center cancer researcher James Goldenring, M.D., Ph.D., has received a two-year, $200,000 grant from the DeGregorio Family Foundation in Pleasantville, New York, to begin clinical trials of a potential approach for reversing precancerous stomach lesions.

28 Apr 2017

FDA approves first drug for treating rare form of Batten disease

The U.S. Food and Drug Administration today approved Brineura (cerliponase alfa) as a treatment for a specific form of Batten disease. Brineura is the first FDA-approved treatment to slow loss of walking ability in symptomatic pediatric patients 3 years of age and older with late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), also known as tripeptidyl peptidase-1 (TPP1) deficiency.

27 Apr 2017

Enzyme treatment may prevent or reduce liver damage caused by excess alcohol consumption

An intestinal enzyme previously shown to keep bacterial toxins from passing from the gastrointestinal system into the bloodstream may be able to prevent or reduce the liver damage caused by excess alcohol consumption.

25 Apr 2017

Enzyme News and Research

Scientists study cell’s reaction to Salmonella by visualizing protein chains at near-molecular level

Study reveals role of good-guy protein in initiating and maintaining cancer

Study findings suggest how progranulin deficiency causes frontotemporal dementia

Study uncovers potential new therapeutic targets for HCV infections

Enzyme supplement can potentially reduce uncomfortable symptoms in gluten-sensitive patients

Scientists identify RIOK1 enzyme as new target for cancer therapy

Researchers find new way to make influenza visible to the naked eye

New mutation predisposes patients under osteoporosis treatment to atypical femur fractures, study finds

Research findings reveal new approach to prevent age-related obesity

Researchers uncover new mechanism that explains cause of portal hypertension

Knocking out lipid-modifying enzyme can boost post-heart attack healing, study shows

Researchers uncover molecule that may explain smoking-CHD connection

TACC's supercomputers assist in discovery of new, better chemotherapy drugs

MDI Biological Laboratory investigator awarded NIH grant for research on peripheral neuropathy

German scientists unravel defense strategy of mushrooms against insect larvae

Learning key 'danger zones' can help plastic surgeons to enhance safety of facial filler procedures

Takeda announces accelerated approval from FDA for new lung cancer treatment

VUMC researcher receives grant to test efficacy of drug for reversing precancerous stomach lesions

FDA approves first drug for treating rare form of Batten disease

Enzyme treatment may prevent or reduce liver damage caused by excess alcohol consumption

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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