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'Turbocharged' protein holds promise in hemophilia gene therapy

Using gene therapy to produce a mutant human protein with unusually high blood-clotting power, scientists have successfully treated dogs with the bleeding disorder hemophilia, without triggering an unwanted immune response.

13 Mar 2015

UH professor part of personalized medicine panel session at SXSW Health and MedTech Expo

University of Houston professor Preethi Gunaratne will be part of a panel addressing personalized medicine at the South by Southwest (SXSW) Health and MedTech Expo in Austin Tuesday, March 17.

13 Mar 2015

Finding could lead to more effective, less invasive treatment for 'bubble boy' disease

For infants with severe combined immunodeficiency (SCID), something as simple as a common cold or ear infection can be fatal. Born with an incomplete immune system, kids who have SCID--also known as "bubble boy" or "bubble baby" disease--can't fight off even the mildest of germs.

12 Mar 2015

Melbourne researchers develop new genome editing technology to kill blood cancer cells

Melbourne researchers have developed a new genome editing technology that can target and kill blood cancer cells with high accuracy.

12 Mar 2015

Oxis Biotech executes licensing agreement with MCIT for development of antibody-drug conjugates

Oxis Biotech, Inc., a wholly owned subsidiary of Oxis International, Inc., announced today the execution of a definitive licensing and development agreement with MultiCell Immunotherapeutics, Inc. concerning the development of certain antibody-drug conjugates (ADCs).

12 Mar 2015

European scientists identify gene linked with certain types of early-onset epilepsy

Certain types of early-onset epilepsy are caused by previously unknown mutations of a potassium channel gene, KCNA2. The mutations disrupt the electrical balance in the brain in two ways. In some patients, the flow of potassium is greatly reduced; while in others, it is raised enormously. Both states can lead to hard-to-treat epileptic seizures. Mental and motor development can come to a stop, or even to regress.

12 Mar 2015

New study shows how presenilin gene mutations may lead to familial Alzheimer's disease

Mutations in the presenilin-1 gene are the most common cause of inherited, early-onset forms of Alzheimer's disease. In a new study, published in Neuron, scientists replaced the normal mouse presenilin-1 gene with Alzheimer's-causing forms of the human gene to discover how these genetic changes may lead to the disorder.

12 Mar 2015

Weak spots in ebola’s defenses: an interview with Dr. Andrew Ward

There are hundreds of other antibodies against Ebola that we are in the process of imaging using the electron microscope. We are looking for new sites of vulnerability as well as subtle differences in the way the known sites are attacked. In particular we are looking for antibodies that the virus is unlikely to escape from when it mutates.

11 Mar 2015

Understanding the role of next generation sequencing in stratified cancer medicine

Oxford Gene Technology, The Molecular Genetics Company, has teamed up with clinical research experts in a new article available online, discussing the role of next generation sequencing (NGS) in cancer medicine.

From Oxford Gene Technology 11 Mar 2015

Type 2 diabetes less common in patients with familial hypercholesterolemia

The prevalence of type 2 diabetes among 25,000 patients with familial hypercholesterolemia (a genetic disorder characterized by high low-density lipoprotein [LDL] cholesterol levels) was significantly lower than among unaffected relatives, with the prevalence varying by the type of gene mutation, according to a study in the March 10 issue of JAMA.

11 Mar 2015

Study supports use of ThyraMIR, ThyGenX Thyroid Oncogene Panel to improve thyroid cancer diagnosis

PDI, Inc. subsidiary, Interpace Diagnostics, announced today new data supporting the use of combination platform testing with ThyraMIR, the first and only microRNA expression classifier, and ThyGenX Thyroid Oncogene Panel, a DNA and RNA mutational analysis, to improve thyroid cancer diagnosis.

11 Mar 2015

Brain tumor experts launch revolutionary fast-track approach to cancer research

Brain tumor experts at Barrow Neurological Institute at Dignity Health St. Joseph's Hospital and Medical Center have launched a revolutionary fast-track approach to cancer research, giving new hope to brain cancer patients.

10 Mar 2015

Salk scientists move one step closer to creating drug that could prevent HIV virus

Imagine a single drug that could prevent human immunodeficiency virus (HIV) infection, treat patients who have already contracted HIV, and even remove all the dormant copies of the virus from those with the more advanced disease. It sounds like science fiction, but Salk scientists have gotten one step closer to creating such a drug by customizing a powerful defense system used by many bacteria and training this scissor-like machinery to recognize the HIV virus.

10 Mar 2015

Understanding genetic machinery that drives malignant pediatric adrenocortical tumors

In an advance that could lead to better identification of malignant pediatric adrenocortical tumors, and ultimately to better treatment, researchers have mapped the "genomic landscape" of these rare childhood tumors. Their genomic mapping has revealed unprecedented details, not only of the aberrant genetic and chromosomal changes that drive the cancer, but the sequence of those changes that trigger it.

10 Mar 2015

Study: A family history of prostate cancer may increase women's risk of developing breast cancer

Having a family history of prostate cancer among first-degree relatives may increase a woman's risk of developing breast cancer. That is the conclusion of a new study published early online in CANCER, a peer-reviewed journal of the American Cancer Society.

10 Mar 2015

Loyola's Genomics Facility uses next generation sequencing to study genetic make-up of organisms

Loyola University Chicago's Genomics Facility is using an advanced technology called next generation sequencing to assist a broad range of researchers studying the genetic make-up of organisms ranging from viruses to humans.

9 Mar 2015

BUSM researchers shed new light on the underlying processes of tumor metastasis

In a review article recently published in the journal Clinical and Translational Medicine, researchers from Boston University School of Medicine (BUSM) shed new light on the underlying processes of tumor metastasis and highlight the role of epigenetics in this process.

9 Mar 2015

Rare, aggressive subtype of pediatric acute lymphoblastic leukemia has surprisingly few mutations

The St. Jude Children's Research Hospital--Washington University Pediatric Cancer Genome Project reports that a highly aggressive form of leukemia in infants has surprisingly few mutations beyond the chromosomal rearrangement that affects the MLL gene. The findings suggest that targeting the alteration is likely the key to improved survival.

9 Mar 2015

Naturally occurring melatonin may help us fall asleep

If you walk into your local drug store and ask for a supplement to help you sleep, you might be directed to a bottle labeled "melatonin." The hormone supplement's use as a sleep aid is supported by anecdotal evidence and even some reputable research studies.

9 Mar 2015

Unregulated Internet marketing of cancer-related gene tests poses challenges for consumers, physicians

Websites that market personalized cancer care services often overemphasize their purported benefits and downplay their limitations, and many sites offer genetic tests whose value for guiding cancer treatment has not been shown to be clinically useful, according to a new study from Dana-Farber Cancer Institute.

6 Mar 2015

Mutation News and Research

'Turbocharged' protein holds promise in hemophilia gene therapy

UH professor part of personalized medicine panel session at SXSW Health and MedTech Expo

Finding could lead to more effective, less invasive treatment for 'bubble boy' disease

Melbourne researchers develop new genome editing technology to kill blood cancer cells

Oxis Biotech executes licensing agreement with MCIT for development of antibody-drug conjugates

European scientists identify gene linked with certain types of early-onset epilepsy

New study shows how presenilin gene mutations may lead to familial Alzheimer's disease

Weak spots in ebola’s defenses: an interview with Dr. Andrew Ward

Understanding the role of next generation sequencing in stratified cancer medicine

Type 2 diabetes less common in patients with familial hypercholesterolemia

Study supports use of ThyraMIR, ThyGenX Thyroid Oncogene Panel to improve thyroid cancer diagnosis

Brain tumor experts launch revolutionary fast-track approach to cancer research

Salk scientists move one step closer to creating drug that could prevent HIV virus

Understanding genetic machinery that drives malignant pediatric adrenocortical tumors

Study: A family history of prostate cancer may increase women's risk of developing breast cancer

Loyola's Genomics Facility uses next generation sequencing to study genetic make-up of organisms

BUSM researchers shed new light on the underlying processes of tumor metastasis

Rare, aggressive subtype of pediatric acute lymphoblastic leukemia has surprisingly few mutations

Naturally occurring melatonin may help us fall asleep

Unregulated Internet marketing of cancer-related gene tests poses challenges for consumers, physicians

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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