Adenine News and Research

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Adenine is one of the four bases in DNA that make up the letters ATGC, adenine is the "A". The others are guanine, cytosine, and thymine. Adenine always pairs with thymine.

Scientists map cancer mutations in EGFR gene, revealing drug resistance paths

Researchers used base and prime editing to uncover new EGFR gene mutations that affect cancer progression and drug resistance, paving the way for personalized treatment strategies.

14 Nov 2024

Mitochondria’s division of labor sheds light on how cancer cells survive harsh conditions

Research shows mitochondria form distinct subpopulations under nutrient stress, revealing survival mechanisms in cancer cells and potential therapeutic targets.

12 Nov 2024

Adenine base editors show potential to correct X-CGD-causing mutations

A collaborative effort between investigators at the National Institutes of Health's National Institute of Allergy and Infectious Diseases (NIAID) and Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham healthcare system, demonstrates the potential of precise genome editing technologies, called adenine base editors, to correct disease-causing mutations in stem cells from patients with X-linked chronic granulomatous disease (X-CGD), a rare genetic disorder characterized by high susceptibility to infections.

16 Oct 2024

Enhancing mRNA lifespan: A step forward in therapeutic development

mRNA-based therapeutics and vaccines are the new hope in the fight against incurable diseases. A commonly used strategy in the development of messenger RNA (mRNA) medicine is based on the destruction of disease-causing mRNA.

16 Oct 2024

Distinct fecal metabolites identified for non-invasive diagnosis of endometriosis

Researchers identify distinct gut microbiome metabolites in women with endometriosis, offering potential for non-invasive diagnosis and new therapies.

14 Oct 2024

CKMT2 regulates mitochondrial function and energy metabolism in type 2 diabetes

Creatine kinase M2 (CKMT2) plays a key role in mitochondrial dysfunction in type 2 diabetes, affecting energy metabolism in skeletal muscle.

10 Oct 2024

New research offers hope for treating metabolic dysfunction-associated liver disease

Metabolic dysfunction-associated steatotic liver disease (MASLD) — previously known as "non-alcoholic fatty liver disease" — affects about 25% of the global population.

9 Oct 2024

Researchers identify a protein that recharges T cells for long-lasting cancer remission

Research shows Fc–IL-4 revitalizes exhausted CD8+ T cells, boosting antitumor responses and highlighting the potential of combining type 1 and type 2 immunity.

30 Sep 2024

Calcium channel blockers show potential to restore cerebral blood flow in Alzheimer's disease

Targeting calcium channels in pericytes may improve blood flow in Alzheimer's disease, addressing early vascular dysfunction linked to cognitive deficits.

23 Sep 2024

Garlic’s antioxidant and nitric oxide boosting effects may help lower blood pressure

Scientific evidence supports garlic's antihypertensive effects, detailing the mechanisms of action and key compounds that contribute to cardiovascular benefits.

3 Sep 2024

New discovery reveals how DNA regulates inheritance of disease mutations

University of Queensland researchers have discovered a mechanism in DNA that regulates how disease-causing mutations are inherited.

21 Aug 2024

Study reveals new insights into urea cycle's role in fatty liver disease

An Indiana University School of Medicine physician scientist is making strides in understanding the molecular origins of fatty liver disease, a leading cause of liver failure in the United States.

16 Aug 2024

IU research sheds light on urea cycle defects and fatty liver disease

An Indiana University School of Medicine physician scientist is making strides in understanding the molecular origins of fatty liver disease, a leading cause of liver failure in the United States.

13 Aug 2024

ATP regulation in ClC-3 exchangers linked to neurodegenerative diseases, study reveals

Researchers structurally analyzed adenine nucleotide control and neurodegenerative diseases in ClC-3 exchangers.

11 Aug 2024

Review of fasting-mimicking diets in cancer treatment

Researchers present the role of cyclic fasting and fasting-mimicking diets (FMD) in cancer therapy.

8 Aug 2024

Seaweed extract shows promise in protecting neurons in Parkinson’s disease

Ecklonia cava polyphenols (ECPs) show promise in reducing neuronal damage caused by rotenone in Parkinson’s disease (PD) by activating the Nrf2-ARE pathway, highlighting their potential as a neuroprotective treatment.

7 Aug 2024

Study finds higher levels of lncRNAs in the testes than previously estimated

Researchers at the University of Toronto have mapped the spatial distribution of around 700 long non-coding RNAs, otherwise known as lncRNAs, in the testes.

30 Jul 2024

One-time prime editing targets common genetic cause of cystic fibrosis

Researchers optimized prime editing for the efficient correction of the cystic fibrosis transmembrane conductance regulator F508del mutation in human airway epithelial cells, achieving high correction efficiencies and functional restoration with minimal off-target effects.

15 Jul 2024

St. Jude researchers uncover NLRC5's role in immune response and cell death

The innate immune system is responsible for protecting the human body from threats that could cause disease or infection.

14 Jun 2024

HiDEF-seq technique reveals the origins of DNA mutations in single strands

Mutations are changes in the molecular "letters" that make up the DNA code, the blueprint for all living cells. Some of these changes can have little effect, but others can lead to diseases, including cancer.

12 Jun 2024