Antipsychotic News and Research

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Antipsychotics are medicines used to treat the symptoms of mental disorders such as schizophrenia, depression, bipolar disorder (sometimes called manic-depressive illness), anxiety disorders, and attention deficit-hyperactivity disorder (ADHD). Sometimes medications are used with other treatments such as psychotherapy.

Aston University launches initiative to tackle medication-induced weight gain

Dr. Jo Howe and Professor Ian Maidment from Aston Pharmacy School have won funding for a new project to develop new ways to mitigate weight gain caused by antipsychotic medication.

9 Jan 2025

Do GLP-1 receptor agonists increase the risk of suicide in patients?

A nationwide study confirms GLP-1 RAs pose no short-term psychiatric risk, showing a negative association with suicidal behaviors in high-risk populations.

6 Jan 2025

New research affirms clozapine safety with minimal blood cancer risk

An inter-departmental research team at the LKS Faculty of Medicine of the University of Hong Kong (HKUMed) has conducted the world's first analytic real-world cohort study on the association of clozapine, a highly efficacious antipsychotic drug, with the incidence of blood cancer.

2 Jan 2025

Common brain network connected to heterogeneous patterns of brain atrophy in schizophrenia

A new study led by investigators from Mass General Brigham has identified a unique brain network that links varied patterns of brain atrophy, or shrinkage, associated with schizophrenia.

12 Dec 2024

Antipsychotics linked to increased behavioral problems in nursing homes

A new study conducted by researchers at the University of Waterloo analyzed data from nearly 500,000 Canadian patients who lived in nursing homes across Canada between 2000 and 2022.

6 Dec 2024

Scientists aim to identify the most effective TBS protocols for treating schizophrenia

Schizophrenia, which is characterized by positive symptoms (e.g., hallucinations and delusions), negative symptoms (diminished emotional expressions or avolition), and cognitive impairments (attention deficits and poor learning skills), is a serious mental health condition that affects how individuals think, behave, and perceive the world.

3 Dec 2024

New brain biomarker could enable early diagnosis of psychosis

The current standard of care for psychosis is a diagnostic interview, but what if it could be diagnosed before the first symptom emerged? Researchers at the Del Monte Institute for Neuroscience at the University of Rochester are pointing toward a potential biomarker in the brain that could lead to more timely interventions and personalized care.

25 Nov 2024

Researchers discover effective treatment strategy for lethal glioblastoma

Glioblastoma (GBM) is the most lethal brain tumor, with a median survival rate of merely 12-16 months after diagnosis. Despite surgical, radiation and chemotherapy treatments, the two-year survival rate for GBM patients is less than 10%.

7 Oct 2024

Study reveals sponsorship bias in psychiatric drug trials

Psychiatric drugs are reported to be about 50% more effective in clinical trials funded by the drug's manufacturer than when trials of the same drug are sponsored by other groups, new research shows.

7 Oct 2024

Study highlights urgent need for improved care for schizophrenia

New research finds that adults with schizophrenia spectrum disorders have high rates of comorbid mental and substance use disorders and significant social and economic disadvantages, and only 26% received minimally adequate treatment.

23 Sep 2024

Understanding the risk of NMS in young patients

A new study in the peer-reviewed Journal of Child and Adolescent Psychopharmacology estimated the incidence of neuroleptic malignant syndrome (NMS), a potentially fatal adverse effect of antipsychotic treatment, among individuals ages 5-24 years.

19 Sep 2024

Tossed medicine, delayed housing: How homeless sweeps are thwarting Medicaid’s goals

Andrew Douglass shoved his clothes and belongings into plastic trash bags as five police officers surrounded his encampment — a drab gray tent overflowing along a bustling sidewalk in the gritty Tenderloin neighborhood, where homeless people lie sprawled on public sidewalks, sometimes in drug overdoses.

16 Sep 2024

Young mental health patients at risk from drug interactions

A new study reveals that young patients treated with psychiatric medications receive potentially dangerous combinations with concerning frequency.

6 Sep 2024

Girls with mental illness less likely to receive HPV vaccination

Girls with mental illness or neurodevelopmental conditions are less likely than their peers to be vaccinated with the HPV vaccine that protects against future cervical cancer.

29 Aug 2024

Addressing HPV vaccination disparities in girls with mental health conditions

Girls with mental illness or neurodevelopmental conditions are less likely than their peers to be vaccinated with the HPV vaccine that protects against future cervical cancer. This is according to a new registry study from Karolinska Institutet in Sweden published in The Lancet Public Health.

29 Aug 2024

AlphaFold accelerates discovery of potential antipsychotic drugs by outperforming traditional methods

Researchers used AlphaFold and homology modeling to identify potent TAAR1 agonists, showing AlphaFold's superior performance in drug discovery for neuropsychiatric conditions.

13 Aug 2024

Evidence lacking for widespread youth psychotropic prescribing

There's limited evidence to back up the widespread and increasing rates of prescribing mood-altering drugs (psychotropics) as the mainstay of mental health treatment for children and young people, warn experts in an editorial, published in the August issue of Drug and Therapeutics Bulletin (dtb)

30 Jul 2024

Clozapine improves outcomes in treatment-resistant schizophrenia

The Psychiatry and Mental Health research group at the Germans Trias i Pujol Research Institute (IGTP), together with the ETEP (Study and Treatment of Psychotic Episodes) group at Hospital del Mar, has published a study in the Spanish Journal of Psychiatry and Mental Health that analyzes the use of clozapine in patients with treatment-resistant schizophrenia in the first two years after the first psychotic episode (FEP).

12 Jul 2024

Study reveals link between the use of antipsychotics in dementia and socioeconomic status

A study led by the Economic Evaluation of Chronic Diseases group of Biogipuzkoa Health Research Institute has revealed the relationship between the use of antipsychotics in dementia and socioeconomic status.

2 Jul 2024

Discovery of nanoparticle-based drug delivery system could revolutionize schizophrenia treatment

Schizophrenia is a complicated mental health disorder accompanied by wide range of symptoms such as hallucinations, impaired cognitive ability, and disorganized speech or behavior.

27 Jun 2024