Biotherapeutics News and Research

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Harbour BioMed partners with Insilico to accelerate AI-powered antibody discovery

Harbour BioMed (HKEX: 02142, the "Company"), a global biopharmaceutical company committed to the discovery, development and commercialization of novel antibody therapeutics focusing on immunology and oncology, and Insilico Medicine ("Insilico"), a clinical stage generative artificial intelligence (AI)-driven biotechnology company, today announced a strategic collaboration to accelerate the discovery and development of innovative therapeutic antibodies, leveraging their respective technological strengths in antibody discovery and artificial intelligence.

21 Feb 2025

Yale rewrites genetic code for new proteins

Synthetic biologists from Yale were able to re-write the genetic code of an organism - a novel genomically recoded organism (GRO) with one stop codon - using a cellular platform that they developed enabling the production of new classes of synthetic proteins. These synthetic proteins, researchers say, offer the promise of innumerable medical and industrial applications that can benefit society and human health.

11 Feb 2025

Gyros Protein Technologies introduces Gyrolab HEK293 HCP Type SN and Type CL Kit Reagents to support biotherapeutic development

Gyros Protein Technologies AB, a pioneer in automated nanoliter-scale immunoassays and leading provider of peptide synthesizers, today announced the introduction of its Gyrolab® HEK293 HCP Type SN Kit Reagents and Gyrolab HEK293 HCP Type CL Kit Reagents.

6 Feb 2025

Study reveals major differences between human and mouse PD-1 in cancer research

Since its discovery in the 1990s, "programmed cell death protein 1," or PD-1, has been regarded as a leading target in cancer treatments.

3 Jan 2025

Genetic mutation in esophageal cancer found to have dual effects

A genetic fault long believed to drive the development of esophageal cancer may in fact play a protective role early in the disease, according to new research published in Nature Cancer.

3 Jan 2025

Study uncovers how cancer builds molecular bridges to evade the immune system

"Build your enemy a golden bridge to retreat across" is a piece of advice offered by Sun Tzu in his ancient military treatise, The Art of War.

23 Dec 2024

Harnessing exosomes to deliver therapeutic proteins

Researchers at The Ottawa Hospital and the University of Ottawa have discovered an 18-digit code that allows proteins to attach themselves to exosomes - tiny pinched-off pieces of cells that travel around the body and deliver biochemical signals.

11 Dec 2024

Customizable biological sensors activate cancer immunotherapy only in tumor environments

Most cancer treatments – from chemotherapies to engineered immune cells – have a host of side effects, in large part because they affect healthy cells in the body at the same time as targeting tumor cells.

15 Nov 2024

Space-grown stem cells show promise for accelerating biotherapies

Stem cells grown in microgravity aboard the International Space Station (ISS) have unique qualities that could one day help accelerate new biotherapies and heal complex disease, two Mayo Clinic researchers say.

4 Nov 2024

Southwest Research Institute breaks ground on new clinical supply facility

Southwest Research Institute broke ground today on a new 21,000-square-foot Clinical Supply Facility to support government and industry clients with integrated pharmaceutical and bioengineering research and development.

23 Oct 2024

Assessing and addressing IP staffing needs in a pediatric setting

A new paper published today in the American Journal of Infection Control (AJIC) describes efforts at a major children's hospital to assess and fulfill its staffing needs for infection prevention and control, highlighting the challenges of allocating sufficient resources to this important role.

17 Oct 2024

Scientists uncover role of Wnt in kidney formation

A group of essential signaling molecules known as the Wnt pathway emerged early in the evolution of multicellular life. Scientists have been studying Wnt actions for four decades to comprehend its complex roles in development and disease.

1 Oct 2024

Scientists develop novel technique to combat T cell exhaustion

Fighting cancer is exhausting for T cells. Hostile tumor microenvironments can drain their mitochondrial activity, leading to a condition known as T cell exhaustion. This phenomenon also hinders adoptive cell therapies, in which healthy, tumor-targeting T cells are infused into patients with cancer. A novel method to boost mitochondrial activity and charge up T cells is needed.

14 Sep 2024

WHO adds MVA-BN vaccine to prequalification list as first vaccine against mpox

The World Health Organization (WHO) has announced the MVA-BN vaccine as the first vaccine against mpox to be added to its prequalification list.

13 Sep 2024

New discovery offers hope for overcoming CAR-T cell therapy resistance

Mayo Clinic researchers mined the molecular foundations of cancer and uncovered a new reason chimeric antigen receptor (CAR-T cell therapy) fails in some patients.

12 Sep 2024

New evidence supports continuous infusion for GI cancers

New research just published online by JNCCN - Journal of the National Comprehensive Cancer Network finds that for many commonly used treatment regimens targeting metastatic gastrointestinal (GI) cancers, such as FOLFOX, FOLFIRI, or FOLFIRINOX, it is possible to administer 5-FU solely through continuous infusion, minus the bolus (quick-delivery via intravenous push) component, without negatively affecting patient outcomes.

6 Sep 2024

Breakthrough research identifies key microenvironments linked to kidney injury and disease

A study published in Nature Communications provides new insight into how damaged cells interact within disease-promoting microenvironments following acute kidney injury, or AKI.

5 Sep 2024

Discovery of Tr1 cells as a barrier to cancer immunotherapy offers new hope for treatment

Immunobiologists Robert Schreiber, PhD, (left) and Hussein Sultan, PhD, of Washington University School of Medicine in St. Louis, found that a subset of immune cells that normally puts the brakes on the immune system to prevent it from attacking the body's healthy cells inadvertently also dampens cancer immunotherapy.

7 Aug 2024

Researchers uncover immune system barrier to cancer treatment

By recruiting the immune system to combat tumor cells, immunotherapy has improved survival rates, offering hope to millions of cancer patients. However, only about one in five people responds favorably to these treatments.

7 Aug 2024

CD5 knockout using CRISPR boosts CAR T cell therapy efficacy

The effectiveness of CAR T cell therapy against a variety of cancers, including solid tumors, could be boosted greatly by using CRISPR-Cas9 technology to knock out the gene for CD5, a protein found on the surface of T cells, according to a preclinical study from investigators at the University of Pennsylvania's Perelman School of Medicine and Abramson Cancer Center.

19 Jul 2024