Bone Marrow Transplant News and Research

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CRISPR revolutionized: New method edits genes directly in the body

Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.

1 Feb 2024

CRISPR cures on the horizon: Breakthrough center aims to heal rare, deadly genetic diseases

Children and adults with rare, deadly genetic diseases have fresh hope for curative therapies, thanks to a new collaboration between the Innovative Genomics Institute (IGI) and Danaher Corporation, a global life sciences and diagnostics innovator.

9 Jan 2024

Spatial profiling predicts recurrence of Hodgkin lymphoma after bone marrow transplant

Cedars-Sinai Cancer investigators have discovered a new way to predict whether a cancer of the immune system will recur in patients treated with a bone marrow transplant.

22 Dec 2023

Embryonic immune sensor could key to creating patient-derived blood stem cells

A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, valuable new insight in the effort to create patient-derived blood stem cells that could eliminate the need for bone marrow transplants.

19 Dec 2023

Quizartinib extends life and enhances wellbeing for AML patients with key mutation

In a study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, patients recently diagnosed with a common and aggressive form of acute myeloid leukemia reported having improved quality of life when a newly approved drug was part of the treatment plan.

11 Dec 2023

Many patients may not benefit from gene-editing treatments for sickle cell disease

Federal approval of a breakthrough gene-editing technology that treats the pain and debilitating effects of sickle cell disease is cause for celebration among a community with few options for relief.

8 Dec 2023

UT Arlington researchers develop improved model for predicting cancer cure rates

With the rapid development in computing power over the past few decades, machine-learning (ML) techniques have become popular in medical settings as a way to predict survival rates and life expectancies among patients diagnosed with diseases such as cancer, heart disease, stroke, and, more recently, COVID-19.

20 Nov 2023

Autologous stem cell transplant shows promise for young patients with severe juvenile systemic sclerosis

New research at ACR Convergence 2023, the American College of Rheumatology's (ACR) annual meeting, shows that patients with refractory juvenile systemic sclerosis improved significantly on nearly all measures for two years following autologous stem cell transplant.

10 Nov 2023

Sickle cell disease patients willing to accept high risks for gene therapy cure

Individuals living with severe sickle cell disease (SCD) are highly interested in new, potentially curative gene therapy treatments and are willing to accept associated risks for a chance at a cure, according to a study published today in Blood Advances.

31 Oct 2023

Potato starch supplement may help prevent gvhd in bone marrow transplant patients

Researchers at Baylor College of Medicine and the University of Michigan conducted a phase I pilot study to assess the feasibility of using potato starch as a dietary intervention to modify the gut microbiome in bone marrow transplant patients.

19 Oct 2023

New gene therapy offers hope for beta thalassemia patients

UCSF Benioff Children's Hospital Oakland provides new therapy to first patient since FDA approval.

31 Aug 2023

Universal approach could potentially expand CAR T cell therapy to all blood cancers

A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer.

31 Aug 2023

MGH opens first-of-its-kind center to eliminate lifelong immunosuppression after organ transplant

Massachusetts General Hospital (MGH), a founding member of the Mass General Brigham health system, officially opened the Legorreta Center for Clinical Transplant Tolerance, the first-of-its kind center in the world dedicated to preventing organ rejection after transplant surgery without the use of lifelong immunosuppressive medications.

1 Aug 2023

Three doses of mRNA vaccine provide good protection for vulnerable people

Even vulnerable people, who are at risk of severe Covid-19, achieved good antibody levels after three doses of mRNA vaccine.

1 Aug 2023

New gene editing approach could revolutionize the treatment of blood disorders

In a step forward in the development of genetic medicines, researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have developed a proof-of-concept model for delivering gene editing tools to treat blood disorders, allowing for the modification of diseased blood cells directly within the body.

27 Jul 2023

Experimental antibody treatment shows promise for preventing bone marrow transplant complication

An experimental antibody treatment largely prevented a bone marrow transplant complication called graft versus host disease (GVHD) in the intestines, without causing broad immune suppression, in a preclinical study led by researchers from Penn Medicine and Dana-Farber/Boston Children's Cancer and Blood Disorders Center and published today in Science Translational Medicine.

28 Jun 2023

Bone Marrow Transplant News and Research

CRISPR revolutionized: New method edits genes directly in the body

CRISPR cures on the horizon: Breakthrough center aims to heal rare, deadly genetic diseases

Spatial profiling predicts recurrence of Hodgkin lymphoma after bone marrow transplant

Embryonic immune sensor could key to creating patient-derived blood stem cells

Quizartinib extends life and enhances wellbeing for AML patients with key mutation

Many patients may not benefit from gene-editing treatments for sickle cell disease

UT Arlington researchers develop improved model for predicting cancer cure rates

Autologous stem cell transplant shows promise for young patients with severe juvenile systemic sclerosis

Sickle cell disease patients willing to accept high risks for gene therapy cure

Potato starch supplement may help prevent gvhd in bone marrow transplant patients

New gene therapy offers hope for beta thalassemia patients

Universal approach could potentially expand CAR T cell therapy to all blood cancers

MGH opens first-of-its-kind center to eliminate lifelong immunosuppression after organ transplant

Three doses of mRNA vaccine provide good protection for vulnerable people

New gene editing approach could revolutionize the treatment of blood disorders

Experimental antibody treatment shows promise for preventing bone marrow transplant complication

New standard more effective at preventing graft-versus-host disease

MD Anderson and Ochsner Health join forces to advance cancer care in Louisiana

Newborn screening for "bubble-baby" disease boosts survival of children

New base-edited T-cells proven effective to treat lymphoblastic leukemia

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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