Crystallography News and Research

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First crystal structure of alternative DNA shape from the insulin gene revealed

The first crystal structure of an alternative DNA shape from the insulin gene has been revealed by a UCL-led research team.

9 Sep 2024

Engineered heart tissues uncover new mechanisms in lupus-related heart damage

Cardiovascular disease is the leading cause of death in patients suffering from lupus, an autoimmune disease in which our immune system attacks our own tissues and organs, the heart, blood, lung, joints, brain, and skin.

20 Aug 2024

Controllable chiral switching in double-helical foldamers for advanced molecular systems

The deoxyribonucleic acid or DNA, the molecular system that carries the genetic information of living organisms, can transcribe and amplify information using its two helical strands.

9 Aug 2024

How machine learning is accelerating research in structural biology

For Lucas Farnung, there is no question more fascinating than how a single fertilized egg develops into a fully-functioning human.

2 Aug 2024

Unraveling the role of liquid-liquid phase separation in neurodegenerative diseases

Liquid-liquid phase separation is not a precursor to formation of amyloid fibrils, a pathological hallmark of Parkinson's disease, shows study.

15 Jul 2024

Study provides new clues in the understanding of how antibiotic resistance spreads

A study at Umeå University, Sweden, provides new clues in the understanding of how antibiotic resistance spreads.

1 Jul 2024

Breakthrough in enzyme communication could pave the way for new drugs

A mechanism that could help scientists harness enzymes for use in drug discovery has been discovered in a research breakthrough at the University of Birmingham.

20 Jun 2024

Novel method for 'rationally engineering' enzymes to deliver improved performance

Scientists have prototyped a new method for "rationally engineering" enzymes to deliver improved performance.

20 Jun 2024

Discovery paves the way for more specific cancer drugs with fewer side effects

The small protein ubiquitin is involved in almost every cellular process in our body: it orchestrates the stability and function of the vast majority of proteins.

6 Jun 2024

Advancing therapeutic insights: The impact of understanding cellular target engagement with NanoBRET® technology

In this Interview, NewsMedical speaks with Amy Landreman about NanoBRET® Technology and its role in cellular target engagement.

From Promega Corporation 30 May 2024

AlphaFold2 can be an effective tool in structure-based drug discovery

One of the most consequential advances in artificial intelligence isn't an eerily conversational chatbot - it's a new way to unpack the unique 3D structures of proteins.

17 May 2024

Reviving a rejected drug: New selective antibiotic shows promise

Twenty years ago, a drug candidate was rejected due to its side effects. Researchers have now figured out how to potentially make a successor molecule more selective.

17 May 2024

St. Jude researchers unveil mechanisms to block PXR and enhance drug potency

Deaths from cancer or infections can occur when available treatments are ineffective. Once turned on, pregnane X receptor (PXR) activates the expression of genes encoding enzymes that metabolize external chemicals, including drugs.

14 May 2024

Scripps Research professor emeritus John Johnson selected as member of the National Academy of Sciences

Scripps Research professor emeritus John Johnson, PhD, has been elected to the National Academy of Sciences—one of the highest honors given to scientists.

11 May 2024

Study reveals deadly bacteria's attraction to human blood

Some of the world's deadliest bacteria seek out and feed on human blood, a newly-discovered phenomenon researchers are calling "bacterial vampirism."

16 Apr 2024

Atomic-level structural models of enzymes provide disease insights

When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system.

2 Apr 2024

Researchers identify viable vaccine targets for hepatitis C infections

By studying individuals who spontaneously clear hepatitis C infections, a team of researchers has identified viable vaccine targets for a disease that infects 70 million worldwide with case numbers increasing every year.

26 Mar 2024

New drug candidates show promise to reverse HIV immune evasion

University of Pittsburgh School of Medicine scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.

19 Mar 2024

New drug candidate designed at the atomic level could help halt emerging SARS-CoV-2 variants

Although COVID-19 has faded from the headlines, SARS-CoV-2 – the coronavirus behind the pandemic – is still rampantly infecting people around the world.

14 Mar 2024

NIH study uncovers vulnerable sites on Epstein-Barr virus protein

Studies of interactions between two lab-generated monoclonal antibodies (mAbs) and an essential Epstein-Barr virus (EBV) protein have uncovered targets that could be exploited in designing treatments and vaccines for this extremely common virus.

12 Mar 2024