Hyperalgesia News and Research

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Raptor Pharmaceutical to present oral AMPA-kainate antagonist data at the neuropathic pain conference

Raptor Pharmaceutical Corp., today announced that data from a clinical trial of NGX426, the Company's orally administered non-opioid, AMPA/kainate antagonist, will be presented at the 12th International Conference on the Mechanisms and Treatment of Neuropathic Pain, to be held November 20-21, 2009 in San Francisco.

5 Nov 2009

Endocannabinoids found to spread and prolong pain

Imagine that you're working on your back porch, hammering in a nail. Suddenly you slip and hit your thumb instead - hard. The pain is incredibly intense, but it only lasts a moment. After a few seconds (and a few unprintable words) you're ready to start hammering again.

13 Aug 2009

Compound from coral offers hope fpr neuropathic pain

A compound initially isolated from a soft coral (Capnella imbricata) collected at Green Island off Taiwan, could lead scientists to develop a new set of treatments for neuropathic pain - chronic pain that sometimes follows damage to the nervous system.

4 Aug 2009

Opioid antagonists show potential for problematic pain

Achieving effective, durable, and safe pain relief, especially in patients with chronic and/or severe pain conditions, can be difficult.

2 Apr 2009

Opioid antagonists help pain management

Achieving effective, durable, and safe pain relief, especially in patients with chronic and/or severe pain conditions, can be difficult.

3 Mar 2009

Leconotide, an investigative calcium channel blocker, shows potential as pain treatment

Results of a pre-clinical study of leconotide, an investigative calcium channel blocker, shows it has the potential to be safe, selective, and efficacious as a new non-opioid treatment for pain relief. It also holds promise in multiple drug delivery options including nasal spray, transdermal patch, and pills. Data were presented today at the American Academy of Pain Medicine's 25th Annual Meeting.

29 Jan 2009

KAI Pharmaceuticals reports positive results for KAI-1678 in pain reduction

KAI Pharmaceuticals, Inc., a privately held drug discovery and development company, today announced preclinical results demonstrating the effectiveness of KAI-1678 in reversing pain (hyperalgesia and allodynia) in multiple preclinical models.

19 Nov 2008

Cannabis reduces pain only within a narrow dose range

Although smoking "moderate" doses of cannabis helps reduce pain in healthy research volunteers, pain is actually increased at high doses.

24 Oct 2007

Nastech Pharmaceutical Co. issued patents for parathyroid hormone nasal spray for treatment of osteoporosis

Nastech Pharmaceutical Company Inc. has announced the issuance of two U.S. patents by the U.S. Patent and Trademark Office.

18 Jul 2007

Genetic analysis of opioid-induced hyperalgesia

In findings published in Nature Biotechnology (May 2006, vol. 24 No. 5), Roche scientists present a new method for analyzing the metabolism of a commonly prescribed drug.

10 May 2006

Hearing protein TRPA1 also involved with pain perception

The same protein that “translates” sound into nerve signals to the brain and enables individuals to hear is also required for pain perception, researchers from Northwestern University Feinberg School of Medicine have found.

21 Jul 2005

Protein TRPA1 essential for hearing also vital for pain perception

The same protein that "translates" sound into nerve signals to the brain and enables individuals to hear is also required for pain perception, researchers from Northwestern University Feinberg School of Medicine have found.

25 May 2005

Reflex sympathetic dystrophy syndrome may affect more than 1.2 million

Paula Abdul's story about her struggle with Reflex Sympathetic Dystrophy Syndrome (RSD), also known as Complex Regional Pain Syndrome (CRPS) highlights this complex and poorly understood disorder.

23 Apr 2005