Intrauterine Growth Restriction News and Research

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Current fetal growth standards do not consider racial and ethnic differences

Current standards for ultrasound evaluation of fetal growth may lead to misclassification of up to 15 percent of fetuses of minority mothers as being too small, according to a study by researchers at the National Institutes of Health (NIH) and other institutions.

29 Sep 2015

WSU researcher secures $1.25 million NIH grant to study role of rosiglitazone drug in reversing preeclampsia

Sascha Drewlo, Ph.D., assistant professor of obstetrics and gynecology for the Wayne State University School of Medicine, has secured a $1.25 million grant from the National Heart, Lung and Blood Institute of the National Institutes of Health to study the role of approved drugs to improve placental function.

8 Jul 2015

Researchers review ten years of scientific studies on mitochondrial toxicity in pregnant women

Researchers from the Hospital Clinic of Barcelona (Spain) have reviewed ten years' worth of scientific studies on mitochondrial toxicity in pregnant women. Exposure to toxic agents such as viruses, certain drugs, pesticides, alcohol and tobacco cause mitochondrial diseases about which very little is known, and which are transmitted from the mother to the foetus.

20 Feb 2015

Opioid abuse in pregnant women increases 127% in 14 years

The number of pregnant women who abuse or are dependent on opioids (narcotics) jumped 127 percent in 14 years, leading to an increased risk of maternal death and stillbirth among other serious problems, according to a review of more than 57 million American women admitted for delivery.

19 Nov 2014

Preeclampsia study provides pathways for new therapeutic treatments

A team of researchers led by a Wayne State University School of Medicine associate professor of obstetrics and gynecology has published findings that provide novel insight into the cause of preeclampsia, the leading cause of maternal and infant death worldwide, a discovery that could lead to the development of new therapeutic treatments.

27 Oct 2014

Infant and adult weight interact to determine urinary incontinence risk

A woman’s weight at birth together with her weight in adulthood influence the risk of incident urinary incontinence, results of a nationwide twin study suggest.

28 May 2014

Study shows relative increase of 322% for severe pre-eclampsia

A latest study by researchers at the Mailman School of Public Health and Columbia University Medical Center reports that pre-eclampsia, characterized by an elevation in the blood pressure and excess protein in the urine of pregnant women, has a 1.5-fold to 2-fold higher incidence in first pregnancies. The condition, which causes complications in approximately 3-6% of all pregnancies, is also associated with high risks of preterm delivery, intrauterine growth restriction, placental abruption, and perinatal mortality. Findings are published online in the British Medical Journal.

22 Nov 2013

Biomarker may predict poor pregnancy outcomes in lupus patients

Researchers at Hospital for Special Surgery in New York City have identified a biomarker that may predict poor pregnancy outcomes in lupus patients.

28 Oct 2013

Antenatal taurine reduces cerebral cell apoptosis in fetal rats with intrauterine growth restriction

Increased brain cell apoptosis in intrauterine growth-restricted fetal rats is a key reason for unfavorable long-term prognosis of the nervous system. The harmful effects of intrauterine growth restriction on fetal brain development originate in the womb.

6 Sep 2013

Samoan epidemic of obesity may start with rapid weight gain in early infancy

As some Pacific island cultures have "westernized" over the last several decades, among the changes has been a dramatic increase in obesity. Researchers don't understand all the reasons why, but even a decade ago in American Samoa 59 percent of men and 71 percent of women were obese. A new Brown University study finds that the Samoan epidemic of obesity may start with rapid weight gain in early infancy.

6 Feb 2013

Isolated fetal echogenic bowel ‘may be benign’

Results of a Dutch study show that the majority of fetuses with fetal echogenic bowel carry a good prognosis.

9 Oct 2012

Maternal factors associated with fetal growth restriction

A Japanese study has found that maternal rather than fetal factors are associated with fetal growth restriction. A comparison of maternal and fetal angiotensin-converting enzyme genotypes with the size of babies at birth found evidence of this connection.

27 Jun 2012

Protein in blood can predict improper growth of fetus

Researchers from the Ottawa Hospital Research Institute (OHRI) and the University of Ottawa (uOttawa) have found a protein in the blood of pregnant women that can predict if they are likely to have a fetus that doesn't grow properly, and thus has a high risk of stillbirth and long-term health complications.

22 Jun 2012

UCLA geneticists identify mutation responsible for IMAGe syndrome

UCLA geneticists have identified the mutation responsible for IMAGe syndrome, a rare disorder that stunts infants' growth. The twist? The mutation occurs on the same gene that causes Beckwith-Wiedemann syndrome, which makes cells grow too fast, leading to very large children.

28 May 2012

Starvation during childhood may increase risk of heart complications

Russians born during the Leningrad Siege in World War II, which was responsible for some of the greatest losses of civilian life in history, are giving scientists new strategies to identify people who experienced intrauterine growth restriction (IUGR) and starvation during childhood at greatest risk of developing long term heart complications.

31 Mar 2012

Low dose carbon monoxide therapy can prevent fetal death

Heme oxygenase-1 is essential for the growth of blood vessels in the placenta and in establishing blood flow in the umbilical cord. Too little HO-1 can lead to a restriction in the growth of the fetus and even in fetal death and miscarriage. New research published in BioMed Central's open access journal Medical Gas Research has shown that low dose carbon monoxide therapy is able to restore placental function and prevent fetal death in mice, without any detrimental effects.

19 Feb 2012

Cesarean delivery may increase risk of breathing problems in preterm babies

Research conducted at Yale School of Medicine shows that a cesarean (C-section) delivery, which was thought to be harmless, is associated with breathing problems in preterm babies who are small for gestational age.

13 Feb 2012

Preterm C-section could raise risk of breathing difficulties: Study

Cesarean sections are often performed when a baby is going to be born early. Labor may also be induced when a woman's water breaks too early in the pregnancy. However, two new studies suggest that these common practices may, in fact, not benefit babies. The two new studies were presented Thursday at the annual meeting of the Society for Maternal-Fetal Medicine.

12 Feb 2012

Resveratrol helps prevent metabolic syndrome in offspring

Researchers in the Faculty of Medicine & Dentistry at the University of Alberta have discovered that resveratrol, a powerful antioxidant found in common foods, prevents a syndrome in some offspring that could lead to later health issues such as diabetes.

3 Sep 2011

Study finds abnormal fetal circulation as a risk factor for fetal thrombotic vasculopathy

Examination of the placenta can offer answers to the questions that arise following an adverse perinatal outcome, such as stillbirth or intrauterine growth restriction. A placental lesion known as fetal thrombotic vasculopathy (FTV) has been associated with a number of adverse outcomes. By studying placentas with this lesion, researchers hope to determine the risks of such serious complications that affect fetuses and newborns.

19 Apr 2011