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Senolytic therapy delays early disc degeneration in mouse model

Targeting senescent cells with dasatinib-quercetin preserves disc structure and modulates degeneration-associated pathways in a mouse model.

25 May 2026

Scientists reveal why common pancreatic precancer lesions rarely turn deadly

Spatial and single-cell analyses of human donor pancreata showed that PanIN epithelial cells gradually acquire cancer-like molecular features, while their surrounding stromal and immune environment remains closer to normal pancreatic tissue. The findings suggest that delayed or incomplete microenvironmental reprogramming may help explain why most PanIN lesions remain indolent rather than progressing to pancreatic cancer.

24 May 2026

Pim1 identified as promising therapeutic target for inflammatory arthritis treatment

The research team led by Professor Zhongyu Xie from Sun Yat-sen University revealed a new mechanism by which Pim1 regulated Th17 cell differentiation through mitochondrial metabolism.

22 May 2026

Targeting lipid enzymes triggers starvation states in aggressive tumor cells

While many American adults are trying to reduce cholesterol levels, certain cancerous tumors have a relentless appetite for the metabolite.

22 May 2026

Explainable AI could make breast cancer drug predictions safer and clearer

AI-driven genomic analysis could help researchers identify existing drugs that may be repurposed for subtype-specific breast cancer treatment. The review proposes an interpretability-driven framework that links multi-omics data, mechanistic validation, and clinical translation to make AI predictions more transparent and clinically useful.

22 May 2026

Study reveals cellular mechanisms driving resistance to targeted cancer therapies

Despite impressive innovations in medicine, most advanced-stage cancers still carry a grim prognosis. Developing more effective treatments requires a deeper understanding of the cellular processes that drive the formation and growth of common cancers.

20 May 2026

Real-world study compares leading ALK+ lung cancer treatments

A team of researchers from the Keck School of Medicine of USC, the USC Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences and the USC Shaeffer Center for Health Policy & Economics have conducted a head-to-head comparison of five leading treatments for anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer.

19 May 2026

New therapies could help type 1 diabetes care move beyond insulin alone

Disease-modifying therapies for type 1 diabetes are beginning to move care beyond insulin replacement by targeting immune dysregulation, beta-cell stress, and preservation of endogenous beta-cell function. Teplizumab marks a major clinical milestone, but the review emphasizes that durable metabolic remission will likely require earlier screening, better patient selection, and sequential or combination therapies.

18 May 2026

Aged immune cells may drive memory decline by releasing a brain-aging protein

A preclinical mouse study in Immunity suggests that aged circulating CD8+ T cells can disrupt hippocampal function and impair learning and memory. The findings point to granzyme K, a secreted factor linked to age-associated CD8+ T cells, as a potential target for restoring aspects of cognition in aging.

17 May 2026

Prenatal chemical mixtures may influence fetal growth and placental health

Common environmental chemicals could affect birthweight and placental function, according to a new study published in Environmental Science & Technology and led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by "la Caixa" Foundation. Conducted within the Barcelona Life Study Cohort (BiSC), the research underscores the importance of considering real-life exposure to complex chemical mixtures and highlights the role of angiogenic biomarkers in linking these exposures to fetal development.

17 May 2026

New guidelines for identifying and treating high-risk IEC-HS patients

Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment of hematologic malignancies, offering durable responses for patients with otherwise refractory disease. However, its clinical success is accompanied by a spectrum of immune-related toxicities, which remain a major challenge in practice.

15 May 2026

Scientists identify genetic mechanisms connected to core autism behaviors

A long‑overlooked stretch of the human genome appears to play a distinct role in shaping the social and stereotypic repetitive behaviors that define Autism Spectrum Disorder (ASD), without affecting learning or other cognitive abilities, according to a major new study published in Nature.

13 May 2026

Garlic-derived compound may help improve muscle strength during aging

Can a compound derived from a common kitchen ingredient help support muscle health during aging? A new study suggests it can.

7 May 2026

Cranberry juice may help stop antibiotic resistance in UTIs

Cranberry juice potentiates fosfomycin against UPEC, lowering resistance rates and modifying bacterial absorption pathways for improved antibiotic efficacy.

7 May 2026

Organic lithium salts may affect many cellular level changes in Alzheimer's disease

Lithium chloride may affect many cellular level changes in Alzheimer's disease, a new study from the University of Eastern Finland (UEF) shows.

6 May 2026

Tumor splicing burden predicts treatment response in kidney cancer

Researchers at City of Hope® and TGen (part of City of Hope) have identified a significant correlation between a tumor's "splicing burden" and its clinical response to treatment for metastatic renal cell carcinoma (mRCC).

5 May 2026

GADD45B promotes apoptosis in intestinal injury through DNA demethylation

Intestinal ischemia/reperfusion (I/R) injury is a common pathophysiological phenomenon that is widely present in various primary intestinal diseases and systemic critical illnesses, potentially leading to multiple organ dysfunction and failure, with high morbidity and mortality.

5 May 2026