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Study offers insight into molecular biology of the brain in bipolar disorder patients

In a comprehensive study involving one of the largest-ever samples of post-mortem brains, scientists at the Lieber Institute for Brain Development, in collaboration with researchers at the Johns Hopkins School of Medicine and Bloomberg School of Public Health, have pinpointed significant differences in gene expression in two specific regions of the brains of hundreds of patients who had bipolar disorder.

7 Mar 2022

Recently evolved region of the ‘dark genome’ provides clues to treatment of schizophrenia, bipolar disorder

Scientists investigating the DNA outside our genes - the 'dark genome' - have discovered recently evolved regions that code for proteins associated with schizophrenia and bipolar disorder.

23 Dec 2021

Study shows aberrant changes over time in the brains of people with bipolar disorder

Bipolar disorder (BD) is a debilitating psychiatric disorder characterized by fluctuating periods of depression and mania.

3 Nov 2021

Do pre-existing mental disorders and their co-occurrence affect COVID-19 clinical outcomes?

Researchers conducted a study to assess how pre-existing mental disorders are associated with a SARS-CoV-2 infection and how different clusters of mental disorders affect COVID-19 clinical outcomes.

27 Oct 2021

Study investigates whether continued magnetic seizure therapy can prevent relapse of depression

Treatment-resistant depression or TRD is exactly what it sounds like: a form of mental illness that defies effective therapy. It is not rare, with an estimated 3 million persons in the United States suffering from TRD.

20 Oct 2021

Bipolar disorder patients experiencing manic episodes likely to show abnormal brain changes

Patients with bipolar disorder who experience manic episodes are more likely to show abnormal brain changes over time, according to one of the largest longitudinal brain imaging studies in its field to date.

29 Sep 2021

Specific dietary guidelines may help people with bipolar disorders to better manage their health

Can specific dietary guidelines help people living with bipolar disorders better manage their health? Maybe someday, according to a new study by Penn State College of Medicine researchers. Clinical trial results showed that a diet designed to alter levels of specific fatty acids consumed by participants may help patients have less variability in their mood.

24 Sep 2021

Long-term injectables plus counseling improve medication adherence in bipolar disorder patients

Researchers have found that adherence to taking medications improved in people with bipolar disorder with the use of long-term injectable meds combined with psychosocial intervention.

17 Sep 2021

“Batman Sam” fights cancer with care from Johns Hopkins Children’s Center

"What the heck is happening?" recalls Melissa Southward, the mother of now-three-year-old Sam, when he started having nose bleeds and developed a yellowish skin color in August 2020.

8 Sep 2021

Patient-psychotherapist matching improves outcomes of mental health treatment

In first-of-its kind research led by a University of Massachusetts Amherst psychotherapy researcher, mental health care patients matched with therapists who had a strong track record of treating the patients' primary concerns had better results than patients who were not so matched.

29 Jun 2021

Newly identified genetic variants play a role in bipolar disorder

Researchers from the Danish psychiatry research-project iPSYCH have contributed to identify 33 new genetic variants which, as it turns out, play a role in bipolar disorder.

26 May 2021

Distribution of lithium in the brain plays key role in depressive disorders

Depressive disorders are among the most frequent illnesses worldwide. The causes are complex and to date only partially understood. The trace element lithium appears to play a role.

21 May 2021

Six key factors determine medication adherence in people with bipolar disorder

People with bipolar disorder may not take their medication because of side effects, fear of addiction and a preference for alternative treatment - according to research from Norfolk and Suffolk NHS Foundation Trust (NSFT) and the University of East Anglia (UEA).

19 May 2021

Study offers a promising blood test for depression, bipolar disorder

Worldwide, 1 in 4 people will suffer from a depressive episode in their lifetime. While current diagnosis and treatment approaches are largely trial and error, a breakthrough study by Indiana University School of Medicine researchers sheds new light on the biological basis of mood disorders, and offers a promising blood test aimed at a precision medicine approach to treatment.

8 Apr 2021

Study demonstrates long-term neuropsychological consequences following SARS-CoV-2 infection

The study, published in the pre-print server medRxiv, demonstrates the presence of long-lasting neuropsychological sequelae after COVID-19, regardless of the respiratory disease's severity.

2 Mar 2021

Study could provide a new tool to predict relapse in bipolar disorder

Relapse in people with bipolar disorder can be predicted accurately by their tendency towards having pessimistic beliefs, according to a study published today in eLife.

10 Nov 2020

Combination therapy is more effective at preventing recurrence of bipolar disorder

A review of 39 randomized clinical trials by scientists from UCLA and their colleagues from other institutions has found that combining the use medication with psychoeducational therapy is more effective at preventing a recurrence of illness in people with bipolar disorder than medication alone.

15 Oct 2020

Electroconvulsive therapy can reduce suicide risk by 84% in bipolar patients

One of the largest ever studies of patients with untreatable bipolar disorder has shown that ECT (Electroconvulsive Therapy) was able to reduce suicide risk by 84% in high-risk patients, as well as giving effective treatment to around 72% of sufferers.

12 Sep 2020

Study examines the brain's reactions in conditions of uncertainty

A new Tel Aviv University study examined the brain's reactions in conditions of uncertainty and stressful conflict in an environment of risks and opportunities.

2 Sep 2020

New model predicts the impact of outbreaks such as COVID-19 on global supply chains

A transportation review written by a professor from the Berlin School of Economics and Law presents a way of analyzing the predicted impacts epidemic outbreaks have on global supply chains and describes the results of a simulation-based analysis of COVID-19 (SARS-CoV-2) as an example.

19 Apr 2020