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Inflammatory macrophages identified as drivers of chronic joint osteoarthritis

Researchers have identified a group of inflammatory macrophages that drive osteoarthritis by sustaining inflammation in the synovium – a layer of connective tissue within joints – and show that they can target these immune cells to treat the disease in mice.

28 Oct 2026

Researchers identify protein that drives chronic inflammation in psoriasis

In new preclinical studies, researchers have identified a protein that propels a vicious cycle of skin inflammation in psoriasis.

28 Oct 2026

Human challenge study reveals how preexisting immunity affects dengue

Dengue virus is especially pernicious compared with many other viruses, as secondary infections can actually be worse than the first one.

28 Oct 2026

Dual-targeting antibody successfully tackles multiple tumor types in mice

A novel antibody therapy empowers the immune system's tumor-fighting capabilities in mice by targeting immune-suppressing T cells with greater precision than previous approaches, according to new work.

28 Oct 2026

Brain development eliminates flawed neurons to ensure genomic integrity

During fetal development, the human brain generates an excess of neurons, most of which are eliminated shortly before and after birth.

28 Oct 2026

Prefrontal cortex activity fails to predict individual emotion regulation

A supervisor criticizes a report in front of the entire team – you feel exposed and hurt. But if you tell yourself, "She takes my work seriously and wants the project to succeed," the same situation can lose some of its intensity. In psychology, this deliberate reinterpretation is called cognitive reappraisal.

28 Oct 2026

Landmark studies map how genetic differences drive human diseases

In three landmark studies published in Nature today, Australian researchers have made major advances in our understanding of how genetic differences between people influence disease.

28 Oct 2026

Nicotine pouches gain rapid popularity among adult tobacco users

A national survey study conducted by the University of Cincinnati found that nicotine pouch use increased sharply in the United States between 2021 and 2024 among adult tobacco users.

28 Oct 2026

Study identifies common mechanism behind widespread cancer mutations

A family of mutations seen in about 20% of human cancers drives malignancy by changing the accessibility of genes to a particular regulatory protein, according to a study by Weill Cornell Medicine investigators.

28 Oct 2026

Bagged salad sales plunge as Cyclospora concern grows online

This year, the U.S. saw its highest annual count of confirmed Cyclospora cases, roughly 20,000, according to the CDC.

28 Oct 2026

Engineered albumin could lead to needle-free, long-lasting protein medicines

Protein-based medicines have transformed the treatment of many diseases, but they often come with a limitation: they must be injected, sometimes repeatedly, because they are rapidly cleared from the bloodstream.

28 Oct 2026

New portable device enables fast and accurate detection of PFAS in water

Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals known for their exceptional resistance to degradation, earning them the nickname "forever chemicals."

28 Oct 2026

Climate change intensifies global health risks, Lancet Countdown report warns

The 2026 Report of the Lancet Countdown on Health and Climate Change finds that many of the health risks and harms of climate change grew faster in the decade since the Paris Agreement was introduced (2016–2025) than in the decade before it (2006–2015).

27 Oct 2026

UK study identifies ways to improve bowel cancer detection in IBD patients

The first UK-wide analysis of bowel screening for patients with inflammatory bowel disease (IBD) has identified opportunities to improve the early detection of cancer.

27 Oct 2026

Pregnancy night shifts associated with higher risk of developmental abnormalities in children

Working night shifts during pregnancy is linked to a heightened risk of neurodevelopmental abnormalities detected by screening in the child by the age of 4, finds research published online in Occupational & Environmental Medicine.

27 Oct 2026

Lab-on-a-chip technology helps predict childhood leukemia treatment responses

More than 120,000 people in the U.S. are living with acute lymphoblastic leukemia (ALL), and 6,000 new cases are diagnosed each year. Of those, more than 3,500 will be in children.

27 Oct 2026

Autistic people report worse menopause symptoms and lower quality of life

A new study by researchers at Bournemouth University has shown that autistic people consistently experience more severe menopausal symptoms than non-autistic people, leading to poorer wellbeing and quality of life.

27 Oct 2026

Plasma proteins offer clues to biological aging and mortality risk

A new study published in Geromedicine has identified 17 plasma proteins associated with all-cause mortality in older adults and found that several of these proteins also track with measures of biological aging across multiple organ systems.

27 Oct 2026

Mutant protein variant explains dominant inheritance of genetic immunodeficiency

New research shows how a mutant form of a protein named STAT3 causes a genetically dominant immunodeficiency.

27 Oct 2026

High-scoring endocrinologists are more likely to prescribe key diabetes drugs

Endocrinologists who scored highest on the American Board of Internal Medicine's Longitudinal Knowledge Assessment (LKA®) were more likely to prescribe a key diabetes drug class following a treatment guidelines update compared to doctors with lower scores.

27 Oct 2026