Plasmid News and Research

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Breakthrough study highlights ATM activation by DNA single-strand breaks

New research from a team of genome scientists and DNA damage response experts breaks new ground in understanding the function of a protein currently limited in clinical trials for cancer treatments.

7 Aug 2024

Groundbreaking method dmSLAY improves antimicrobial peptide effectiveness and safety

Researchers developed a high-throughput method, dmSLAY, to assess thousands of AMP variants, combining it with machine learning to enhance membrane selectivity and reduce toxicity.

1 Aug 2024

New zwitterionic polyion developed for effective plasmid DNA delivery in muscle cells

Researchers from Tokyo Metropolitan University have created a new drug delivering molecule, a zwitterionic polymer complex that can help get plasmid DNA inside cells when injected into skeletal muscle, a crucial step in the expression of therapeutic RNA and proteins.

28 Jul 2024

Rise of multidrug-resistant Salmonella strains in U.S. retail chicken meat

Salmonella infections are a major public health issue in the United States, causing over 1.3 million illnesses annually.

18 Jul 2024

One-time prime editing targets common genetic cause of cystic fibrosis

Researchers optimized prime editing for the efficient correction of the cystic fibrosis transmembrane conductance regulator F508del mutation in human airway epithelial cells, achieving high correction efficiencies and functional restoration with minimal off-target effects.

15 Jul 2024

60 years in the making: Nanoparticles revolutionize nucleotide delivery

Researchers trace the 60-year evolution of lipid nanoparticles (LNPs) for nucleic acid delivery, highlighting their potential to revolutionize gene therapy with safer and more effective treatments.

10 Jul 2024

Engineered E. coli optimizes targeted tumor cell killing and improves biosafety

Live bacteria can be applied in cancer therapy given their ability to deplete nutrients and induce cell death in tumors.

1 Jul 2024

Non-viral gene therapy offers hope for chronic low back pain sufferers

A novel non-viral gene therapy for discogenic back pain (DBP).

20 May 2024

Scientists unlock mystery behind a deadly strain of cholera bacteria

A deadly strain of cholera bacteria that emerged in Indonesia back in 1961 continues to spread widely to this day, claiming thousands of lives around the world every year, sickening millions - and, with its persistence, baffling scientists.

14 May 2024

Novel bispecific antibodies show promise against evolving SARS-CoV-2 variants

Researchers developed bispecific antibodies targeting both the N-terminal and receptor binding domains of SARS-CoV-2, demonstrating significant neutralization across various Omicron variants, suggesting potential for new COVID-19 treatments.

9 May 2024

Sapio Sciences Unveils Enhanced Molecular Biology Toolkit

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From Sapio Sciences 7 May 2024

Asimov achieves 10x improvement in lentiviral production, launches new stable cell line development service

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30 Apr 2024

Leveraging CRISPR/Cas technology to address antimicrobial resistance

In the second new research review on this subject, Assistant Prof. Ibrahim Bitar, Department of Microbiology, Faculty of Medicine and University Hospital in Plzen, Charles University in Prague, Plzen, Czech Republic, will give an overview of the molecular biology of CRISPR technology in explaining how it can used to tackle antimicrobial resistance.

26 Apr 2024

Study reveals human gut plasmid with biomarker potential

A component of the human intestinal flora that has been little studied to date is the focus of a new study.

16 Apr 2024

Hospital sinks fuel antibiotic-resistant bacteria spread

A new study published today in the American Journal of Infection Control reports the infection prevention steps taken to control a months-long multispecies outbreak of carbapenemase-producing Enterobacterales that occurred in a pediatric ward at the Toho University Omori Medical Center in Tokyo in 2017.

12 Apr 2024

Adeno-associated virus: The gene therapy revolution faces manufacturing and safety hurdles

Recombinant adeno-associated virus (rAAV)-based genetic applications to treat human diseases.

5 Apr 2024

Bioengineering edible mycelium to enhance nutritional value, color, and flavor

A modular synthetic biology toolkit for Aspergillus oryzae, an edible fungus used in fermented foods.

21 Mar 2024

T1-spanin breakthrough offers new hope against antibiotic resistance

Given the worldwide prevalence of drug-resistant bacteria, the research fraternity is on the lookout for alternative bactericidal treatment approaches.

12 Mar 2024

INTEGRA supports the next generation of synthetic biologists

INTEGRA Biosciences awarded 3 PIPETBOY acu 2 serological pipette controllers to the 2023 iGEM Competition team at Technische Universität Braunschweig (TU_BS) to aid their pioneering research into lithium therapy toxicity testing.

From INTEGRA Biosciences 8 Mar 2024

Adipose-derived stem cell exosomes play protective roles in mitigating myocardial injury

Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at investigating the expression and therapeutic potential of circRNAs from adipose-derived stem cell (ADSC) exosomes (ADSC-Exos) for cardiomyocyte injury.

7 Mar 2024