Tumor Associated Macrophages News and Research

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Spatial organization of immune cells predicts outcomes for patients with clear cell renal cell carcinoma

Outcomes for patients with clear cell renal cell carcinoma have improved over the past decade due to the approval of immunotherapies, yet still there is a subset of patients who do not respond to this type of therapy.

26 Apr 2023

Novel gel offers hope for patients with glioblastoma

Medication delivered by a novel gel cured 100% of mice with an aggressive brain cancer, a striking result that offers new hope for patients diagnosed with glioblastoma, one of the deadliest and most common brain tumors in humans.

24 Apr 2023

Clockwork in cancer: the importance of the circadian rhythm in the formation and progression of tumors

Researchers reviewed the importance of the circadian rhythm in the formation and progression of tumors.

29 Mar 2023

Using a selective dye to label macrophages associated with cancer progression

M1 and M2 are activated macrophages that protect our immune system and maintain homeostasis.

28 Mar 2023

Upgraded tumor model points the way toward more effective cancer therapies

Tumor cells won't show their true selves in a petri dish, isolated from other cells.

20 Mar 2023

Study suggests a link between the protein-coding gene TREM2 and obesity in females

A recent Scientific Reports study has investigated the link between TREM2 expression and human obesity, based on two large public datasets, namely, the UK Biobank (UKB) and the Genotype-Tissue Expression (GTEx) project.

11 Jan 2023

Drug combination elicits efficacious anti-tumor immunity against immunotherapy-resistant cancers

Immunotherapy is a way of treating cancer by reprogramming the patient's immune system to attack their tumor.

10 Jan 2023

Research suggests potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity

A new research paper was published in Oncotarget's Volume 13 on December 20, 2022, entitled, "Resistance of MMTV-NeuT/ATTAC mice to anti-PD-1 immune checkpoint therapy is associated with macrophage infiltration and Wnt pathway expression."

6 Jan 2023

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Researchers have characterised prostate cancer cell dynamics at a single-cell resolution across the timespan of the disease – from its beginning to the point of androgen independence, where the tumour no longer responds to hormone deprivation therapy.

14 Dec 2022

Researchers find the root of immunosuppression and chemoresistance in TNBC tumors

Triple-negative breast cancer (TNBC) tumors gain immunosuppression and chemoresistance through interactions between interleukin 34 and myeloid-derived suppressor cells, researchers find.

1 Nov 2022

Advanced type of nanoparticle could help fight hard-to-treat cancers

Nanoparticles, or tiny molecules that can deliver a payload of drug treatments and other agents, show great promise for treating cancers.

27 Oct 2022

Study develops a strategy to noninvasively track tumor-associated macrophages

A Ludwig Cancer Research study has developed a strategy to noninvasively track immune cells known as macrophages within brain and breast tumors in living mice.

19 Oct 2022

UNO-peptide-modified CCN shows promise for targeted delivery of TAM immunomodulatory agents

Announcing a new publication for Acta Materia Medica journal. Tumor-associated macrophages (TAMs) are key contributors to tumor development, accelerated tumor invasion and metastasis, and induction of immunosuppression.

13 Oct 2022

Cytokine-based cancer immunotherapy: current progress and future prospects

In this interview, News-Medical talks to Dr. Shuang Zhou about cytokine-base cancer immunotherapy, the current state of the field, and future prospects.

From Sino Biological Inc. 18 Jul 2022

Researchers reveal novel tumor–macrophage interactions that promote peritoneal metastasis of ovarian cancer

A research team at the School of Biological Sciences, the University of Hong Kong, has revealed novel cellular and molecular interactions between cancer cells and tumor-associated macrophages that promote peritoneal metastasis of ovarian cancer.

25 May 2022

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Codiak BioSciences, Inc., a clinical-stage biopharmaceutical company pioneering the development of exosome-based therapeutics as a new class of medicines, today announced the online publication of a new manuscript, Exosome mediated genetic reprogramming of tumor associated macrophages by exoASO-STAT6 leads to potent monotherapy anti-tumor efficacy, in the American Association for the Advancement of Science's journal, Science Advances.

18 Feb 2022

Tumor Associated Macrophages News and Research

Spatial organization of immune cells predicts outcomes for patients with clear cell renal cell carcinoma

Novel gel offers hope for patients with glioblastoma

Clockwork in cancer: the importance of the circadian rhythm in the formation and progression of tumors

Using a selective dye to label macrophages associated with cancer progression

Upgraded tumor model points the way toward more effective cancer therapies

Study suggests a link between the protein-coding gene TREM2 and obesity in females

Drug combination elicits efficacious anti-tumor immunity against immunotherapy-resistant cancers

Research suggests potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Researchers find the root of immunosuppression and chemoresistance in TNBC tumors

Advanced type of nanoparticle could help fight hard-to-treat cancers

Study develops a strategy to noninvasively track tumor-associated macrophages

UNO-peptide-modified CCN shows promise for targeted delivery of TAM immunomodulatory agents

Cytokine-based cancer immunotherapy: current progress and future prospects

Researchers reveal novel tumor–macrophage interactions that promote peritoneal metastasis of ovarian cancer

Codiak's publication highlights the ability of exoASO-STAT6 to selectively target tumor-associated macrophages

Study shows how gut bacteria could undermine immunity in pancreatic cancer

Scientists discover low amounts of cholesterol in tumor-associated macrophages

Treatment with antihistamines associated with improved responses to immunotherapy

Study identifies how cancer cells transform macrophages into supporters of their growth

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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