Malignant News and Research

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Distinct genomic patterns of malignant peripheral nerve sheath tumors may help with early diagnosis

Neurofibromatosis type 1 (NF1) is a common genetic condition, affecting 1 in 3000 individuals, and people with NF1 are at greater risk of developing a rare, aggressive form of cancer.

4 Jan 2023

The role of exosomes in osteosarcoma diagnosis, prognosis, and therapeutics

Announcing a new publication for Acta Materia Medica journal. Osteosarcoma, a primary malignant tumor of the skeleton, has a morbidity of 2.5 per 1 million people.

3 Jan 2023

UTSW researchers identify molecular function of 87 inherited genetic variants linked to prostate cancer

UT Southwestern researchers have identified the molecular function of 87 inherited genetic variants that affect the risk of prostate cancer, and the majority appear to control the activity of genes located far away from the risk variants themselves.

23 Dec 2022

AI method can make time-sensitive, critical diagnosis easier and more accessible to pathologists

When a patient undergoes a surgical operation to remove a tumor or treat a disease, the course of surgery is often not predetermined.

23 Dec 2022

CARxALL clinical trial approved to evaluate CAR-T technology for patients with T-cell leukemia subtype

The Spanish Agency of Medicines and Medical Products (AEMPS) has approved the CARxALL clinical trial led by the company OneChain Immunotherapeutics (OCI).

21 Dec 2022

New method uses artificial DNA to target and kill cancer cells

Researchers at the University of Tokyo have used artificial DNA to target and kill cancer cells in a completely new way.

21 Dec 2022

Phenotypic plasticity may allow cancer cells to evade standard therapy

Glioblastomas (GBMs) are incurable brain tumors with a prognosis of about one-and-a half years on average. They are highly resistant to treatment and have defied all attempts at precision therapy.

20 Dec 2022

New imaging agent lights the way for surgeons during lung cancer surgery

Surgery, especially surgery to remove cancerous tumors, relies on a range of tools and techniques as well as on the skill of the surgeon.

19 Dec 2022

New electronic patch can monitor biomolecules in deep tissues

A team of engineers at the University of California San Diego has developed an electronic patch that can monitor biomolecules in deep tissues, including hemoglobin.

16 Dec 2022

Study to determine if a DNA-based blood test can help detect cancer predisposition in NF1 patients

The Children’s Tumor Foundation (CTF) has announced a groundbreaking 3-year study, which it will fund for nearly $2 million, to determine if a DNA-based blood test can offer better understanding and ultimately earlier diagnosis of cancer predisposition in neurofibromatosis type 1 (NF1) patients.

16 Dec 2022

Major treatment advance revealed for adults with newly diagnosed B lineage acute lymphoblastic leukemia

Late-breaking research reveals a major treatment advance for adults with newly diagnosed B lineage acute lymphoblastic leukemia (ALL).

14 Dec 2022

A-HIPI decision model can predict survival in adults with advanced-stage Hodgkin lymphoma

Investigators from Rutgers Cancer Institute of New Jersey, the state's only NCI-designated Comprehensive Cancer Center and leading cancer program along with Tufts Medical Center in Boston, developed and validated the Advanced-stage Hodgkin lymphoma International Prognostication Index (A-HIPI).

12 Dec 2022

Study may allow patients with multiple breast lesions to consider breast-conserving therapy as treatment option

Patients with multiple tumors in the same breast who underwent a lumpectomy followed by radiation therapy had local recurrence rates comparable to those historically observed in patients with a single tumor, according to results from the ACOSOG Z11102 (Alliance) prospective phase II clinical trial, which were presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

9 Dec 2022

Therapeutic activation of p53 could offer new treatment option for salivary gland cancer

Researchers at the University of Michigan Rogel Cancer Center and School of Dentistry found that certain drugs can change the fundamental makeup of cancer stem cells in mouse models of mucoepidermoid carcinoma – a lethal form of salivary gland cancer that currently has no treatment options.

8 Dec 2022

Research explores how alignment of endothelial cells plays a role in cancer metastasis

Preventing metastasis – the development of cancer cells beyond their original location – remains one of the major goals of current cancer research.

6 Dec 2022

The critical role of flow cytometry in CAR+ T-Cell trials

In this interview, Ryan Muise talks to AZoNetwork about the added value of using flow cytometry in CAR T-Cell clinical trials.

From Cerba Research 6 Dec 2022

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

Researchers evaluated blood plasma proteins to identify new targets for COVID-19 treatment approaches and prevent complications associated with severe illness.

5 Dec 2022