Omicron News and Research

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Study provides insight into the natural course of COVID-19 infection in pregnancy

A UT Southwestern study of more than 1,300 pregnant women diagnosed with COVID-19 found that just 1 in 10 developed moderate, severe, or critical illness and that COVID-19 symptoms and severity were similar across all trimesters.

22 Nov 2022

SARS-CoV-2 seroprevalence in domestic cats has increased over time

Researchers evaluated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission among domestic cats in the United Kingdom (UK).

22 Nov 2022

US experienced higher COVID-19 mortality during delta and omicron waves

A recent study estimates coronavirus disease 2019-related mortality and excess all-cause mortality in the US and 20 peer countries during the delta and omicron waves of infection.

22 Nov 2022

Potent hypervalent nanoparticles against HIV, Lassa and SARS-CoV-2 variants

In a recent study published in the journal Advanced Science, researchers developed molecularly imprinted nanoparticles (nanoMIPs) with broad-spectrum activity against lethal viruses.

21 Nov 2022

Additional mRNA COVID vaccine doses could salvage antibody responses in blood cancer patients

A third COVID-19 vaccine dose in this patients with blood cancers could enhance their antibody responses against SARS-CoV-2

21 Nov 2022

New method for isolating Omicron subvariant and evaluating resistance to therapeutic and vaccine-elicited antibodies

Researchers demonstrated a viral amplification procedure to isolate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants.

21 Nov 2022

SARS-CoV-2 infection and mRNA vaccination prime transcriptionally distinct CD4+ T cell memory landscapes

Researchers reported that SARS-CoV-2 infection and mRNA vaccination induce distinct memory T cells.

21 Nov 2022

Bispecific antibodies neutralize Sarbecoviruses with increased breadth and potency

In a recent study posted to the bioRxiv* preprint server, researchers developed bispecific antibodies (bsAbs), neutralizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants.

17 Nov 2022

What is the immune protection generated by SARS-CoV-2 Delta and Omicron BA.1 and BA.2 against Omicron BA.4 and BA.5?

Researchers evaluated immune protection conferred by previous SARS-CoV-2 Delta variant and Omicron BA.1/BA.2 subvariant infections and updated vaccines against Omicron BA.4/5 infections and associated hospitalizations.

17 Nov 2022

Protection afforded by SARS-CoV-2 infection against reinfection when Omicron BA.5 was the dominating subvariant in Scania county, Sweden

Researchers from Sweden conducted a cohort study to evaluate the protection granted by previous SARS-CoV-2 Omicron subvariant infections against reinfections among individuals vaccinated between June and August 2022.

17 Nov 2022

Researchers identify a conserved site on SARS-CoV-2 spike that a broadly neutralizing macrocyclic peptide can target

Researchers explored the efficiency of a macrocyclic peptide in inhibiting the SARS-CoV-2 spike protein.

17 Nov 2022

Omicron BA.2 causes more symptoms and a greater disruption to daily life

In a recent study published in the Nature Communications journal, researchers monitored the changing symptom profiles associated with different severe acute respiratory syndrome CoV-2 (SARS-CoV-2) variants, especially Omicron subvariants BA.1 and BA.2.

16 Nov 2022

Among US veterans with COVID-19, few used antivirals or monoclonal antibodies

In a recent study published in the journal JAMA Network, researchers in the United States investigated factors that restricted the use of antivirals directed at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the United States (US) between January and February 2022.

16 Nov 2022

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

The SARS-CoV-2 Deltacron does not exhibit higher transmissibility or immune evasion than the Omicron BA.1 variant.

16 Nov 2022

SARS-CoV-2 antibodies persist in breast milk following two and three COVID-19 vaccine doses

A new study assesses anti-SARS-CoV-2 antibody levels in breast milk obtained from lactating individuals following two or three COVID-19 vaccine doses.

16 Nov 2022

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

A study published in the journal Frontiers in Immunology describes that the third booster dose of coronavirus disease 2019 (COVID-19) effectively induces an immune response against immunologically more fit variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the immunity induced by the booster vaccination is transient and gradually declines over time.

15 Nov 2022

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

In a recent study published in the journal npj Vaccines, researchers in China designed, produced, and evaluated the neutralization efficacy of a recombinant coronavirus disease 2019 (COVID-19) vaccine containing four hot-spot substitution mutations based on a prefusion-stabilized severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (S) trimer.

15 Nov 2022

Short-term outcomes in pregnant patients with COVID-19 who received nirmatrelvir–ritonavir treatment

Researchers investigated the short-term outcomes of treating pregnant patients exhibiting mild to moderate symptoms of COVID-19 with Paxlovid, which is a combination of the antivirals nirmatrelvir and ritonavir.

15 Nov 2022

Moderna's bivalent boosters trigger strong antibody response against latest subvariants

Moderna reports the efficacy of a bivalent COVID-19 vaccine booster dose.

14 Nov 2022

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

Researchers investigated the change in the stability, antigenicity, and protein expression of the SARS-CoV-2 spike protein trimer using structure-directed mutagenesis to alter a cavity in the core of the spike protein.

14 Nov 2022

Omicron News and Research

Study provides insight into the natural course of COVID-19 infection in pregnancy

SARS-CoV-2 seroprevalence in domestic cats has increased over time

US experienced higher COVID-19 mortality during delta and omicron waves

Potent hypervalent nanoparticles against HIV, Lassa and SARS-CoV-2 variants

Additional mRNA COVID vaccine doses could salvage antibody responses in blood cancer patients

New method for isolating Omicron subvariant and evaluating resistance to therapeutic and vaccine-elicited antibodies

SARS-CoV-2 infection and mRNA vaccination prime transcriptionally distinct CD4+ T cell memory landscapes

Bispecific antibodies neutralize Sarbecoviruses with increased breadth and potency

What is the immune protection generated by SARS-CoV-2 Delta and Omicron BA.1 and BA.2 against Omicron BA.4 and BA.5?

Protection afforded by SARS-CoV-2 infection against reinfection when Omicron BA.5 was the dominating subvariant in Scania county, Sweden

Researchers identify a conserved site on SARS-CoV-2 spike that a broadly neutralizing macrocyclic peptide can target

Omicron BA.2 causes more symptoms and a greater disruption to daily life

Among US veterans with COVID-19, few used antivirals or monoclonal antibodies

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

SARS-CoV-2 antibodies persist in breast milk following two and three COVID-19 vaccine doses

COVID-19 mRNA boosters induce robust but non-durable immune response in the elderly

Development of a potent, broadly protective vaccine against all SARS-CoV-2 variants

Short-term outcomes in pregnant patients with COVID-19 who received nirmatrelvir–ritonavir treatment

Moderna's bivalent boosters trigger strong antibody response against latest subvariants

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

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