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Research shows how TET2 protein loss can open door for mutations that drive blood cancers

Imagine this scenario on a highway: A driver starts to make a sudden lane change but realizes his mistake and quickly veers back, too late. Other motorists have already reacted and, in some cases, collide. Meanwhile, the original motorist - the one who caused the problem - drives on.

25 Apr 2017

Scientists reveal unexpected route to slow progression of diabetic kidney disease

More than 660,000 people in the United States suffer from end-stage kidney disease, which can only be treated by dialysis or kidney transplantation. Almost half of these patients develop the condition as a complication of diabetes.

25 Apr 2017

Tiny silica 'cages' could help store and transport vaccines without refrigeration

Vaccines and antibodies could be transported and stored without refrigeration by capturing them in tiny silica 'cages', a discovery which could make getting vital medicines to remote or dangerous places much easier, cheaper and safer.

24 Apr 2017

SLU researchers make advances in understanding plaque-causing protein in neurological disorders

In a recent paper published in the Journal of Biological Chemistry Yuna Ayala, Ph.D., assistant professor of biochemistry and molecular biology at Saint Louis University, and her research team made advances in understanding how a protein causes damaging plaques to build up in neurodegenerative illnesses like amyotrophic lateral sclerosis (ALS) and a form of dementia called frontotemporal lobar degeneration.

19 Apr 2017

Study shows how interplay between semen and female reproductive tract could impact fertility

For a mammal's sperm to succeed, it must complete the swim of its life to reach and fertilize an egg. That's easier if it swims through water, not goo.

19 Apr 2017

UTHealth participates in study to evaluate effectiveness of new injectable HIV medication

The HIV Prevention Trials Network, which includes McGovern Medical School at The University of Texas Health Science Center at Houston, has launched a study to evaluate whether a new injectable medication can work as well as an existing oral pill to safely protect against HIV among men who have sex with men (MSM) and transgender women (TGW) who have sex with men.

18 Apr 2017

Scientists identify gene responsible for generating key lipid in skin barrier formation

Scientists have identified the gene responsible for generating acylceramide, the key lipid in forming the skin barrier that protects us from pathogens, allergens and other harmful substances. This finding could prove crucial in developing medicines for treating atopic dermatitis and ichthyosis.

17 Apr 2017

Study describes synthesis and biological evaluation of novel, effective ARIs

Diabetes mellitus (DM) is probably one of the oldest known diseases and the incidence has been increasing steadily all over the world. This metabolic disease is characterized by chronic hyperglycemia due to defect in insulin secretion and/or insulin action.

17 Apr 2017

TSRI scientists develop easy method for synthesizing compounds with potential to treat lung disorders

Chemists at The Scripps Research Institute have developed a broad and strikingly easy method for synthesizing a class of molecules that have demonstrated value as pharmaceuticals.

17 Apr 2017

Researchers correct Duchenne muscular dystrophy using gene-editing alternative

Using the new gene-editing enzyme CRISPR-Cpf1, researchers at UT Southwestern Medical Center have successfully corrected Duchenne muscular dystrophy in human cells and mice in the lab.

13 Apr 2017

Microparticles show potential to deliver DNA-based vaccines and gene therapies in pill form

A microscopic corn-and-shrimp cocktail could eventually make DNA-based vaccinations and cancer-treating gene therapies an easier pill to swallow, according to new research from the University of Nebraska-Lincoln.

12 Apr 2017

Scientists solve structure of protein crucial to reproduction and spread of Zika virus

Zika virus is a mosquito-borne infectious disease linked to certain birth defects in infants in South and Central America and the United States.

11 Apr 2017

MIT engineers develop more sensitive approach to reveal ovarian tumors

Most ovarian cancer is diagnosed at such late stages that patients' survival rates are poor. However, if the cancer is detected earlier, five-year survival rates can be greater than 90 percent.

10 Apr 2017

Study explains how genetic mutations linked to telomere capping complex contribute to cancers

Scientists at The Wistar Institute have unveiled part of the protein complex that protects telomeres - the ends of our chromosomes. The study, published online in Nature Communications, explains how a group of genetic mutations associated with this protein complex contributes to various cancers.

10 Apr 2017

Rutgers scientists reveal structure of TB drug target and identify new inhibitors

Rutgers University scientists have determined the three-dimensional structure of the target of the first-line anti-tuberculosis drug rifampin. They have also discovered a new class of potential anti-tuberculosis drugs that kill rifampin-resistant and multi-drug-resistant tuberculosis bacteria.

7 Apr 2017

Researchers identify molecular switch that converts skin cells into blood vessel cells

Researchers from the University of Illinois at Chicago have identified a molecular switch that converts skin cells into cells that make up blood vessels, which could ultimately be used to repair damaged vessels in patients with heart disease or to engineer new vasculature in the lab.

7 Apr 2017

Enzyme News and Research

Research shows how TET2 protein loss can open door for mutations that drive blood cancers

Scientists reveal unexpected route to slow progression of diabetic kidney disease

Tiny silica 'cages' could help store and transport vaccines without refrigeration

SLU researchers make advances in understanding plaque-causing protein in neurological disorders

Study shows how interplay between semen and female reproductive tract could impact fertility

UTHealth participates in study to evaluate effectiveness of new injectable HIV medication

Scientists identify gene responsible for generating key lipid in skin barrier formation

Study describes synthesis and biological evaluation of novel, effective ARIs

TSRI scientists develop easy method for synthesizing compounds with potential to treat lung disorders

Researchers correct Duchenne muscular dystrophy using gene-editing alternative

Microparticles show potential to deliver DNA-based vaccines and gene therapies in pill form

Scientists solve structure of protein crucial to reproduction and spread of Zika virus

MIT engineers develop more sensitive approach to reveal ovarian tumors

Study explains how genetic mutations linked to telomere capping complex contribute to cancers

Rutgers scientists reveal structure of TB drug target and identify new inhibitors

Researchers identify molecular switch that converts skin cells into blood vessel cells

Biomedical engineers develop new method for delivering drugs to specific neurons

Study discovers new role for DNA2 enzyme in repair process

Synthetic biologists engineer gut bacteria capable of sensing colitis

ULCA scientists discover how autoantibodies cause some cases of severe hypertriglyceridemia

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Advancing degrader and proximity-based drug development

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Evaluating new approaches for rare disease genomics

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