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What is the role of monoclonal antibody therapy in treating COVID-19?

A new study has been published in the journal Vaccines that deals with the present state of research on using mAbs for the treatment of the COVID-19 disease. Many clinical trials are being conducted to evaluate the efficacy and safety of several newly designed mAbs. Some of the mAbs are directed towards immune system responses, i.e., non-SARS-CoV-2 specific mAbs, while others are devised to neutralize the SARS-CoV-2 protein structure, i.e., SARS-CoV-2 specific mAbs.

8 Jun 2021

With roots in civil rights, Community health centers push for equity in the pandemic

In the 1960s, health care across the Mississippi Delta was sparse and much of it was segregated. Some hospitals were dedicated to Black patients, but they often struggled to stay afloat.

8 Jun 2021

ACE2 functions as a gateway for COVID-19 virus

Normally, the ACE2 enzyme helps regulate our blood pressure. The enzyme sits on the surface of cells, including cells in the lungs, but in connection with COVID-19 it has been found that ACE2 also functions as a gateway for the virus.

8 Jun 2021

Study reveals mechanisms by which SGLT2 inhibitors produce renoprotective effect

SGLT2 inhibitors (gliflozins) were developed as oral antidiabetics. They enhance urinary glucose excretion by inhibiting SGLT-2 (sodium-dependent glucose co-transporter-2) in the renal tubuli.

8 Jun 2021

Efforts to reduce patients' time on ventilator can spare their suffering and free up ICU resources

More active efforts to reduce patients' time on a ventilator in an ICU can both spare their suffering and free up intensive care resources, a thesis at the University of Gothenburg shows.

8 Jun 2021

Link between SARS-CoV-2 organotropism and kidney injury

It was clear at a relatively early stage of the pandemic that SARS-CoV-2 causes a wide range of symptoms; in addition to typical respiratory symptoms, patients also had neurological symptoms (starting with anosmia), gastrointestinal symptoms, elevated liver values, and renal, urinary or hematological changes, for example.

8 Jun 2021

Reduced use of convalescent plasma associated with higher COVID-19 mortality rate

A new study from researchers at Johns Hopkins Bloomberg School of Public Health and colleagues suggests a slowdown in the use of convalescent plasma to treat hospitalized COVID-19 patients led to a higher COVID-19 mortality during a critical period during this past winter's surge.

8 Jun 2021

Using AI to fight COVID-19

A study based in Taiwan and published in the Journal of Clinical Medicine focuses on the role of AI in managing COVID-19 through digital images, clinical and laboratory analysis such as screening and diagnosis.

7 Jun 2021

Addressing climate change for better kidney health

Health has always been affected by climate and weather, but is increasingly clear that the change in climate is a significant threat to human health.

7 Jun 2021

Study reports safety, efficacy of targeted treatment for IgA nephropathy

IgA nephropathy (IgAN) is a chronic kidney disease occurring in young adults and is one of the most common reasons for kidney transplantation in this age group.

7 Jun 2021

New research identifies protein as therapeutic anti-viral target for COVID-19

New research identified a novel interaction between the SARS-CoV-2 spike protein and the galectin-3-binding protein (LGALS3BP) which could be a new therapeutic anti-viral target.

7 Jun 2021

Ultrasound examinations can be deployed to detect and treat lung congestion in hemodialysis patients

Accumulation of water in the lungs (lungcongestion) is a common condition in hemodialysis patients, particularly in those at high cardiovascular risk, like those presenting coronary artery disease and/or heart failure.

7 Jun 2021

COVID-19 can cause long-term consequences for the kidneys

The kidneys are a target organ of COVID-19 and are affected very early in the course. However, this is precisely where there is strong prognostic potential: As early as last spring, COVID-19-associated nephritis was identified as an early warning signal for severe courses of the infectious disease and studies to that effect were published.

7 Jun 2021

Majority of women do not meet criteria for cervical cancer screening exit

Current guidelines recommend stopping cervical cancer screening at age 65, but women over age 65 make up over one in five new cervical cancer diagnoses, and are twice as likely to die after a cervical cancer diagnosis compared to younger women.

7 Jun 2021

Repeated low-dose dose exposure to SARS-CoV-2 may protect against severe COVID-19

The Italian authors of this paper, published in the journal Viruses, have taken this hypothesis and expanded it to include viral particles suspended in the air or on inanimate objects as a possible source of T cell immunity due to the repeated low-dose exposure, potentially explaining virus immunity found in non-infected individuals.

7 Jun 2021

Redhill Biopharma announces completion of enrollment for oral opaganib phase 2/3 COVID-19 study

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced that it has completed enrollment and randomized the last patient in the global Phase 2/3 study with opaganib (Yeliva, ABC294640) in patients hospitalized with severe COVID-19 pneumonia (NCT04467840).

7 Jun 2021

New report highlights enormous disease burden and treatment gap of osteoporosis in Europe

New International Osteoporosis Foundation report provides unique overview of osteoporosis in Europe, revealing the enormous disease burden and an unacceptable treatment gap; 71% of women at high risk of fracture are not receiving much-needed medication.

7 Jun 2021

Mortality News and Research

What is the role of monoclonal antibody therapy in treating COVID-19?

With roots in civil rights, Community health centers push for equity in the pandemic

ACE2 functions as a gateway for COVID-19 virus

Study reveals mechanisms by which SGLT2 inhibitors produce renoprotective effect

Efforts to reduce patients' time on ventilator can spare their suffering and free up ICU resources

Link between SARS-CoV-2 organotropism and kidney injury

Reduced use of convalescent plasma associated with higher COVID-19 mortality rate

Using AI to fight COVID-19

Addressing climate change for better kidney health

Study reports safety, efficacy of targeted treatment for IgA nephropathy

New research identifies protein as therapeutic anti-viral target for COVID-19

Ultrasound examinations can be deployed to detect and treat lung congestion in hemodialysis patients

COVID-19 can cause long-term consequences for the kidneys

Majority of women do not meet criteria for cervical cancer screening exit

Repeated low-dose dose exposure to SARS-CoV-2 may protect against severe COVID-19

Redhill Biopharma announces completion of enrollment for oral opaganib phase 2/3 COVID-19 study

New report highlights enormous disease burden and treatment gap of osteoporosis in Europe

Study offers overview of SARS-CoV-2 infection in children

The great promise of antiviral peptides against SARS-CoV-2

Trying to avoid racist health care, Black women seek out Black obstetricians

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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