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New source of stem cells could help treat people with Alagille syndrome

Researchers from Sanford Burnham Prebys have discovered a new source of stem cells just outside the liver that could help treat people living with Alagille syndrome, a rare, incurable genetic disorder in which the bile ducts of the liver are absent, leading to severe liver damage and death.

12 Oct 2021

Using genetic screening for selecting the 'best' embryo in IVF

Each year, tens of thousands of babies are born in the United States as the result of IVF (in vitro fertilization) – where several eggs are fertilized outside the mother's body and then an embryo is selected for transfer into her womb.

12 Oct 2021

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Recently, scientists have developed a bacterial two-hybrid (B2H) system to study the PPIs of SARS-CoV-2 in a heterologous non-eukaryotic system. This study is available on the bioRxiv* preprint server. Put simply, the B2H system could be used to analyze the SARS-CoV-2 proteome.

11 Oct 2021

CRISPR/Cas9-directed epigenetic editing reveals diverse transcriptomic regulation and functional effects

Oncotarget published "Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing" which reported that the adequate functioning of this process is indispensable for tissue homeostasis and cell fate determination.

11 Oct 2021

Common oral diuretic pill may be a potential candidate for Alzheimer's treatment

A commonly available oral diuretic pill approved by the U.S. Food and Drug Administration may be a potential candidate for an Alzheimer's disease treatment for those who are at genetic risk, according to findings published in Nature Aging.

11 Oct 2021

New algorithm provides a high-definition analysis of genome organization in single cells

Within the microscopic boundaries of a single human cell, the intricate folds and arrangements of protein and DNA bundles dictate a person's fate: which genes are expressed, which are suppressed, and - importantly - whether they stay healthy or develop disease.

11 Oct 2021

CDC and ClinGen partner to develop expert curated variant list for the genomic community

The Centers for Disease Control and Prevention's Genetic Testing Reference Material Program (GeT-RM) has partnered with the Clinical Genome Resource (ClinGen) to develop a publicly available list of 546 expert curated pathogenic variants in 84 genes for use in next-generation sequencing (NGS) genetic testing.

11 Oct 2021

New metagenome assembler can generate accurate DNA sequences

Metagenomics often involves sequencing DNA samples that can only be described as "tricky." Such DNA shows high heterogeneity, which can cause interspecies misassemblies.

11 Oct 2021

Research finds different antibody responses following COVID vaccination and natural infection

A new study published in the journal Nature attempted to investigate memory B cell evolution 5 months after vaccination with mRNA vaccines such as Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) in SARS-CoV-2 naïve individuals. The study explored various aspects of memory B cell antibody response like neutralizing response, affinity, epitope targeting, and neutralizing breadth.

10 Oct 2021

Accumulation of SARS-CoV-2 mutations reduces sensitivity to neutralizing antibodies

In a new study, researchers discovered that SARS-CoV-2 mutations accumulate, especially in immunocompromised patients.

10 Oct 2021

Lipids, COVID-19, and host immunity

A new study from a team of researchers at the University of Pennsylvania examines the role played by lipids in this disease.

10 Oct 2021

Wyss Center to lead a collaborative project aimed at improving brain cancer treatment

The Wyss Center announced today that it will lead a collaborative project, as part of Wellcome Leap's Delta Tissue Program, to improve understanding of the brain cancer glioblastoma (GBM) and help develop more effective therapies.

8 Oct 2021

Characterization of circulating neutrophils from hospitalized COVID-19 patients

A new preprint deals with the characterization of neutrophil phenotypes in an attempt to provide biomarkers that can predict severe disease in patients hospitalized with COVID-19.

8 Oct 2021

Chilblain-like lesions and COVID-19

The ongoing COVID-19 pandemic brought about by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has also been responsible for various cutaneous manifestations. Among them, chilblain-like lesions (CLL) have been found to occur more frequently.

7 Oct 2021

Common gut bacteria can fuel prostate cancer growth and treatment resistance

Common gut bacteria can fuel the growth of prostate cancers and allow them to evade the effects of treatment, a new study finds.

7 Oct 2021

Existing drug reduces obesity and fatty liver in mice without changes in food intake or daily activity

Researchers at Johns Hopkins Medicine have found that a drug first developed to treat Alzheimer's disease, schizophrenia and sickle cell disease reduces obesity and fatty liver in mice and improves their heart function — without changes in food intake or daily activity.

7 Oct 2021

New technology shows great promise for early diagnosis of Alzheimer’s disease

A technology developed by scientists at Lawrence Berkeley National Laboratory (Berkeley Lab) shows great promise for diagnosing Alzheimer's disease before symptoms arise, potentially changing the course of research and treatment for this condition, which affects millions of people worldwide and is estimated to be the sixth leading cause of death in the United States.

7 Oct 2021

Researcher calls for a broader and more inclusive definition of infertility

Academy Research Fellow Jukka Kekäläinen from the University of Eastern Finland calls for a broader and more inclusive definition of infertility in a recent opinion piece published in the journal Human Reproduction last week.

7 Oct 2021

Scientists identify a new method to treat triple-negative breast cancer

A team of clinicians and scientists from the National Cancer Centre Singapore (NCCS), Singapore General Hospital (SGH) and A*STAR's Genome Institute of Singapore (GIS) has identified a novel method to treat triple-negative breast cancer (TNBC). They discovered that cancer cells switch between different cell states and are able to change from being less aggressive ('epithelial') to being more aggressive ('mesenchymal'), and vice versa.

7 Oct 2021

Planar cell polarity pathway found to be responsible for the formation and maintenance of synapses

Within the brain and other parts of the nervous system, synapses are key junctional points in between neurons (the nerve cells) where critical signals are transmitted. More specifically, the "glutamatergic" synapses are the prime "excitatory" synapse junctions that neurons use to activate each other and are known to have broad diversity in size and shape.

7 Oct 2021

Genes News and Research

New source of stem cells could help treat people with Alagille syndrome

Using genetic screening for selecting the 'best' embryo in IVF

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

CRISPR/Cas9-directed epigenetic editing reveals diverse transcriptomic regulation and functional effects

Common oral diuretic pill may be a potential candidate for Alzheimer's treatment

New algorithm provides a high-definition analysis of genome organization in single cells

CDC and ClinGen partner to develop expert curated variant list for the genomic community

New metagenome assembler can generate accurate DNA sequences

Research finds different antibody responses following COVID vaccination and natural infection

Accumulation of SARS-CoV-2 mutations reduces sensitivity to neutralizing antibodies

Lipids, COVID-19, and host immunity

Wyss Center to lead a collaborative project aimed at improving brain cancer treatment

Characterization of circulating neutrophils from hospitalized COVID-19 patients

Chilblain-like lesions and COVID-19

Common gut bacteria can fuel prostate cancer growth and treatment resistance

Existing drug reduces obesity and fatty liver in mice without changes in food intake or daily activity

New technology shows great promise for early diagnosis of Alzheimer’s disease

Researcher calls for a broader and more inclusive definition of infertility

Scientists identify a new method to treat triple-negative breast cancer

Planar cell polarity pathway found to be responsible for the formation and maintenance of synapses

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