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Mouse brain atlas may help understand the complex circuits of the human brain

The circuits of the human brain contain more than 100 billion neurons, each linked to many other neurons via thousands of synaptic connections, resulting in a three-pound organ that is profoundly more complex than the sum of its innumerable parts.

7 Oct 2021

Study illuminates how BRD4 protein directs the spatial organization of DNA within cell nucleus

New research is advancing understanding of certain cancers and complex congenital disorders by illuminating how BRD4, a protein that scientists have studied for years, directs the spatial organization of DNA within the nucleus of the cell, a function critical for stem cell differentiation into muscle cells.

7 Oct 2021

SARS-CoV-2 evolution promoted by long-term infection in patient with B cell depletion

A new study published on the medRxiv* preprint server focused on a patient with a persistent symptomatic viral infection for over a year. Researchers amplified sub-genomic transcripts for the E gene (sgE) using nasopharyngeal samples of the patient infected with SARS-CoV-2 over the course of 335 days.

6 Oct 2021

Scientists make inroads into creating an atlas of the mouse brain

It takes billions of cells to make a human brain, and scientists have long struggled to map this complex network of neurons.

6 Oct 2021

Neuroscientists unveil detailed atlas of brain cells

When you clicked to read this story, a band of cells across the top of your brain sent signals down your spine and out to your hand to tell the muscles in your index finger to press down with just the right amount of pressure to activate your mouse or track pad.

6 Oct 2021

Novel proteomics approach predicts severe COVID-19 outcomes

Researchers in the United States, Canada, and the UK have developed a potential new approach to predicting severe and critical outcomes among patients with coronavirus disease 2019 (COVID-19).

6 Oct 2021

Graphene biosensor in a portable and wireless device for rapid SARS-CoV-2 detection

A new study posted to the medRxiv* server and led by Dr. Mattia D'Agostino, Dr. Eleonora Pavoni and Dr. Alice Romagnoli from the Polytechnic University of Marche in Ancona (Italy), a gFET biosensor that uses angiotensin-converting enzyme 2 (ACE2) as a bioreceptor has been put forth as a viable solution.

6 Oct 2021

Durability of immunity to SARS-CoV-2 reinfection

The current study used data on the durability of immunity among evolutionarily close coronavirus relatives of SARS-CoV-2 to estimate times to reinfection.

6 Oct 2021

Depression during pregnancy linked with chemical modifications to placental genes

Episodes of maternal stress or depression during pregnancy are associated with chemical modifications to placental genes, according to a study by researchers from the National Institutes of Health.

6 Oct 2021

Gene expression changes during acute SARS-CoV-2 infection may decide long-COVID symptoms

A team of US-based scientists has recently revealed the changes in gene expression profiles associated with the long-term consequences of COVID-19.

6 Oct 2021

First of its kind ‘living medicine’ designed to treat antibiotic-resistant bacteria on medical implants

Researchers at the Centre for Genomic Regulation and Pulmobiotics S.L have created the first 'living medicine' to treat antibiotic-resistant bacteria growing on the surfaces of medical implants. The researchers created the treatment by removing a common bacteria's ability to cause disease and repurposing it to attack harmful microbes instead.

6 Oct 2021

Researchers discover unique self-destructive process in aging nematode worms

As worm mothers age, they secrete a milk-like fluid through their vulva that is consumed by their offspring and supports their growth, according to a new study led by UCL researchers.

6 Oct 2021

Researchers identify mechanism that can lead to deafness in rare Norrie disease

A team of Mass Eye and Ear Scientists led by Albert Edge, PhD, working with research fellow Yushi Hayashi, MD, PhD, has identified the mechanism that can lead to deafness in the rare syndrome, Norrie disease.

5 Oct 2021

Study identifies specific small RNA molecule that can reduce levels of cancer-promoting gene

In a recent study published in CANCER RESEARCH , a team led by researchers at Tokyo Medical and Dental University (TMDU) identified a specific small RNA molecule, called a microRNA (miRNA or miR), that has the potential to be used as an anti-cancer therapeutic.

5 Oct 2021

A possible protective genetic polymorphism in COVID-19

A new study discusses the role of a mucin gene enhancer on the clinical phenotype of the COVID-19.

5 Oct 2021

Three U of U Health researchers win the 2021 NIH Director’s New Innovator Award

The National Institutes of Health has awarded grants to three University of Utah Health scientists through its competitive High-Risk, High-Reward Research (HRHR) program that funds highly innovative and unusually impactful biomedical or behavioral research proposed by extraordinarily creative scientists.

5 Oct 2021

SARS-CoV-2 beta variant elicits variant specific and cross-reactive antibodies

One recent study assessed the serum of Beta variant infected patients to determine whether major non-VOC antibodies could neutralize this virus.

5 Oct 2021

Managing metabolic disease through time-restricted eating

In this interview, News-Medical speaks to Dr. Satchin Panda about his latest research into time-restricted eating and how it can be used to manage metabolic diseases.

5 Oct 2021

J&J vaccine prevents SARS-CoV-2-induced thrombosis and inflammation in hamsters

In a recent study, researchers performed bulk RNA-Seq transcriptomic profiling of lungs from vaccinated and unvaccinated hamsters with the Janssen vaccine.

4 Oct 2021

Using a new public antibody to understand SARS-CoV-2 neutralization

SARS-CoV-2 infects host cells by binding to the angiotensin convertase 2 receptor (ACE2) on the cell surface through its trimeric spike (S) protein. SARS-CoV enters host human cells through endosomes, while SARS-CoV-2 enters through the cell surface and endosomes. The present study published in the journal “Cell Reports” aimed to understand the mechanisms of SARS-CoV-2 antibody neutralization to facilitate the development of therapeutic interventions for COVID-19.

4 Oct 2021