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New study sheds light on why many COVID-19 patients suffer from hypoxia

A new study published in the journal Stem Cell Reports by University of Alberta researchers is shedding light on why many COVID-19 patients, even those not in hospital, are suffering from hypoxia--a potentially dangerous condition in which there is decreased oxygenation in the body's tissues.

2 Jun 2021

Study uncovers mechanisms by which microRNAs drive atherogenesis in a cell-type-specific manner

Researchers at the University of Eastern Finland have uncovered potential mechanisms by which microRNAs (miRNA) drive atherogenesis in a cell-type-specific manner.

2 Jun 2021

Could semen quality indicate SARS-CoV-2 insult susceptibility in polluted areas?

In a recent review in Environmental Science and Pollution Research, Italian researchers focused on “the evidence that correlates the degree and type of pollution with the increased susceptibility of many countries to this pandemic and proposes human semen as an early marker of the environmental health and the general health of individuals.” Their observations are based on a robust body of experimental evidence.

2 Jun 2021

New NIH grant aims to mitigate factors that cause dialysis patients to die

The five-year survival rate for people on dialysis is under 50 percent. University of California researchers are hoping to improve that prognosis.

2 Jun 2021

The ‘grief pandemic’ will torment Americans for years

Cassandra Rollins' daughter was still conscious when the ambulance took her away.

2 Jun 2021

“Cognitive clock” emerges as a new way to measure brain health

Researchers have developed a novel method to monitor the brain health of patients to improve the early diagnosis and treatment of certain diseases.

2 Jun 2021

Women who experience acute aortic dissection are more likely to die than men, shows study

Women who experience acute aortic dissection - a spontaneous and catastrophic tear in one of the body's main arteries - not only are older and have more advanced disease than men when they seek medical care, but they also are more likely to die, according to research published online today in The Annals of Thoracic Surgery.

2 Jun 2021

Positive COVID-19 screening test helps monitor respiration rate, blood-oxygen saturation at home

Two easily measurable signs of health - respiration rate and blood-oxygen saturation - are distinctly predictive of higher mortality among patients hospitalized with COVID-19, according to a study examining the cases of inpatients with COVID-19 at Rush University Medical Center and University of Washington Medicine hospitals.

2 Jun 2021

Mice study shows that Western diet can lead to NASH, liver fibrosis

Apart from lifestyle interventions, there are currently no approved treatments for NASH. A liver transplant is sometimes the only remedy.

2 Jun 2021

Study reveals infections by Histoplasma fungus as major cause of death in people with HIV

A series of autopsies performed in an infectious disease hospital in the Brazilian Amazon reveals that infections by the Histoplasma fungus are a major cause of death in people with HIV.

1 Jun 2021

Antibody cocktail effectively inhibits SARS-CoV-2 in the rhesus macaque model

Researchers from the US tested the prophylactic potential of a combination of 2 mAbs administered 3 or 75 days before respiratory challenge in rhesus macaques. They used the rhesus macaque model to test the added benefit of combinatory parenteral administration of 2 high-affinity anti-SARS-CoV-2 mAbs - C144-LS and C135-LS. These mAbs were developed to neutralize the virus and tweaked to improve their pharmacokinetics.

1 Jun 2021

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

A team of researchers from the US and Belgium applied a structure-based approach with early monitoring of cathepsin L inhibition along with SARS-CoV-2 3CLpro inhibition. They identified a potent and selective SARS-CoV-2 3CLpro inhibitor, ALG-097111, which has proven activity against SARS-CoV-2 in SARS-CoV-2 hamster models in vivo. This study is published in the journal, Biochemical and Biophysical Research Communications.

1 Jun 2021

Study offers longitudinal roadmap of immune activation and resolution in mild COVID-19

Researchers from the US recently profiled the longitudinal immune response in mild COVID-19 patients starting with early time points of 1-15 days post-infection through convalescence to over 100 days after onset of symptoms.

1 Jun 2021

Overweight or obesity amplifies harmful effects of alcohol on the liver

Led by the University of Sydney's Charles Perkins Centre, the study looked at medical data from nearly half a million people and found having overweight or obesity considerably amplified the harmful effects of alcohol on liver disease and mortality.

1 Jun 2021

Using Sotrovimab to treat COVID-19 early

A new study published on the medRxiv* preprint server hypothesized that a monoclonal antibody that has the capability to neutralize all sarbecoviruses could also be used to target a highly conserved epitope. This conserved sequence has a high probability of remaining unchanged in SARS-CoV-2 variants.

31 May 2021

COVID-19 had claimed more than 3 million lives worldwide in 2020

By the end of 2020, COVID-19 had claimed the lives of more than three million people worldwide, representing 1.2 million more deaths than officially reported earlier, says a newly released report by the World Health Organization (WHO).

31 May 2021

More than a third of heat-related deaths attributable to human-induced global warming

Between 1991 and 2018, more than a third of all deaths in which heat played a role were attributable to human-induced global warming, according to a new article in Nature Climate Change.

31 May 2021

COVID-19, mass testing and the utility of wastewater epidemiology

In a recent study, researchers developed a methodology to detect SARS-CoV-2 RNA in wastewater with the potential for finding an association between the wastewater treatment plant (WWTP) SARS-CoV-2 influent viral RNA load and COVID-19 cases in the community. This study indicates that a national scale wastewater-based epidemiology can play a role in COVID-19 surveillance.

31 May 2021

Different early antibody responses define COVID-19 disease trajectory

In a new study posted to the bioRxiv* preprint server, a prospective cohort of patients with COVID-19 exhibited distinct features of the IgG fragment antigen-binding (Fab) and fragment crystallizable (Fc) domains, predicting two distinct disease trajectory two days after a positive test.

31 May 2021

Novel protein interactions with ACE2 disrupted by SARS-CoV-2, contributes to COVID-19 pathologies

A severe and often fatal immune response called a “cytokine storm” can occur following SARS-CoV-2 infection. Some patients suffer from a range of complications several months after testing negative for SARS-CoV-2, and this is called ‘Long Haul’ or ‘Long’ COVID-19. The causes behind this phenomenon are not well understood.

31 May 2021

Mortality News and Research

New study sheds light on why many COVID-19 patients suffer from hypoxia

Study uncovers mechanisms by which microRNAs drive atherogenesis in a cell-type-specific manner

Could semen quality indicate SARS-CoV-2 insult susceptibility in polluted areas?

New NIH grant aims to mitigate factors that cause dialysis patients to die

The ‘grief pandemic’ will torment Americans for years

“Cognitive clock” emerges as a new way to measure brain health

Women who experience acute aortic dissection are more likely to die than men, shows study

Positive COVID-19 screening test helps monitor respiration rate, blood-oxygen saturation at home

Mice study shows that Western diet can lead to NASH, liver fibrosis

Study reveals infections by Histoplasma fungus as major cause of death in people with HIV

Antibody cocktail effectively inhibits SARS-CoV-2 in the rhesus macaque model

ALG-097111 potently inhibits SARS-CoV-2 replication in Syrian Hamster model in vivo

Study offers longitudinal roadmap of immune activation and resolution in mild COVID-19

Overweight or obesity amplifies harmful effects of alcohol on the liver

Using Sotrovimab to treat COVID-19 early

COVID-19 had claimed more than 3 million lives worldwide in 2020

More than a third of heat-related deaths attributable to human-induced global warming

COVID-19, mass testing and the utility of wastewater epidemiology

Different early antibody responses define COVID-19 disease trajectory

Novel protein interactions with ACE2 disrupted by SARS-CoV-2, contributes to COVID-19 pathologies

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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