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Are COVID-19 medications safe in pregnancy?

Most medications being tested today in clinical trials for the treatment of coronavirus disease 2019 (COVID-19) have been repurposed from other indications. These are typically not tested in pregnant women. A new study, published in the journal PLOS ONE, summarizes what is known about the safety of these drugs in this group.

24 May 2021

How conservative are the current COVID-19 pandemic global statistics?

After almost a year and a half of the COVID-19 pandemic, the actual case count of those infected with its causative virus – SARS-CoV-2 – remains unclear. Though well over 167.2 million cases have been reported worldwide, this is certainly believed by many to be a massive undercount. A new epidemiological study uses the classical SIR-C mathematical model to find the peak size and date of cases, both documented and unidentified, and the gap between them.

24 May 2021

Higher BMI linked to higher survival rates in patients hospitalized for severe bacterial infections

For many diseases, overweight and obesity are risk factors. But now a study shows that a higher BMI may be linked to higher survival rates in patients hospitalized for severe bacterial infections.

24 May 2021

Which biomarkers can help predict adverse outcomes in COVID-19?

A team of researchers has conducted a systematic review to identify laboratory factors that can predict the risk of severe and critical COVID-19 as well as associated mortality rates. The team – from institutions in India and the USA – recently published their findings in the Journal of Clinical Medicine Research.

24 May 2021

Study indicates that certain anti-cancer therapies may hasten cellular aging

New research indicates that certain anti-cancer therapies may hasten cellular aging, where changes in the DNA of patients may contribute to greater inflammation and fatigue.

24 May 2021

Researchers identify aluminum hydroxide/TLR9 agonist as potential adjuvant to improve RBD-based COVID-19 vaccine efficacy

The study findings reveal that RBD-based vaccines adjuvanted with the formulation can induce strong anti-SARS-CoV-2 neutralizing immunity in young and aged mice. The study is currently available on the bioRxiv* preprint server.

24 May 2021

Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

Studies have shown that circulating levels of PAI-1, the coagulation cascade activator, are considerably higher in COVID-19 patients with severe respiratory illness compared to patients with bacterial-sepsis and acute respiratory distress syndrome (ARDS). Hence the increase in PAI-1 levels is recognized as an early marker of endothelial dysfunction in COVID-19 patients.

23 May 2021

SARS-CoV-2 virus persistence in immunocompromised individuals

Positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests are frequently obtained from individuals that have already recovered from the virus in the past. They have therefore undergone seroconversion and bear the expected antibodies.

22 May 2021

Landmark study confirms that controlled blood pressure is key to prevent stroke, heart disease

Follow-up data from the landmark SPRINT study of the effect of high blood pressure on cardiovascular disease have confirmed that aggressive blood pressure management -- lowering systolic blood pressure to less than 120 mm Hg -- dramatically reduces the risk of heart disease, stroke, and death from these diseases, as well as death from all causes, compared to lowering systolic blood pressure to less than 140 mm Hg.

22 May 2021

Risk factors for rare COVID-19 complications in children (MIS-C)

While the earlier waves of COVID-19 relatively spared children, some of the affected children have developed a systemic inflammatory condition, with occasionally fatal outcomes. Called multisystem inflammatory syndrome in children (MIS-C), its pathogenesis and risk factors are the subject of a new study on the medRxiv* preprint server.

21 May 2021

Nearly 1 million more deaths relating to COVID-19 occurred in high-income countries

Almost 1 million extra deaths relating to the covid-19 pandemic occurred in 29 high income countries in 2020, finds a study published by The BMJ today.

21 May 2021

Despite frequent vaccinations, COVID-19 could continue to cause recurrent waves and deaths

Covid-19 could continue to cause recurrent waves and deaths despite frequent vaccinations according to a new study from the University of East Anglia.

21 May 2021

Metal complexes against coronavirus

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 3.42 million deaths worldwide. Despite the fact that there are vaccines for SARS-CoV-2, the emergence of new variants and the lack of adequate treatments have encouraged the search for new ways to combat this disease more effectively.

21 May 2021

Total COVID-19 deaths in US counties have been underestimated by 20%, indicates study

Deaths caused by indirect effects of the pandemic emphasize the need for policy changes that address widening health and racial inequities.

21 May 2021

North America has 87% of all unique SARS-CoV-2 S protein variants in the NCBI database among six continents

Recently, a team of researchers from various countries analyzed the unique variants of S proteins across six continents, including Africa, Asia, Oceania, Europe, South America, and North America. They wanted to characterize the unique S protein variants embedded in SARS-CoV-2 genomes infecting millions of people globally.

20 May 2021

Intranasal COVID-19 therapeutic shows promise in preclinical trials

Researchers from the US and Denmark recently described a novel therapeutic option that targets the SARS-CoV-2 ribonucleic acid (RNA) using locked nucleic acid antisense oligonucleotides (LNA ASOs). They identified an LNA ASO that binds to the 5’ leader sequence of SARS-CoV-2 ORF1a/b. This disrupts a highly conserved stem-loop structure with nanomolar efficacy and inhibits viral replication in host cells.

20 May 2021

Blocking TGFβ1 could improve hematopoiesis in AML patients, indicates study

Bone marrow failure due to acute myeloid leukemia (AML) is a significant factor behind the disease's high rate of morbidity and mortality. Previous studies in mice suggest that AML cells inhibit healthy hematopoietic (blood) stem and progenitor cells (HSPC).

20 May 2021

Phase 3 trial: New biologic therapy improves outcomes in adults, adolescents with severe asthma

Results from the NAVIGATOR study of tezepelumab showed that the new biologic therapy significantly reduced exacerbations requiring hospital stays and emergency department (ED) visits for adults and adolescents with severe, uncontrolled asthma, according to research presented at the ATS 2021 International Conference.

20 May 2021

Mistrust in local, national governments is slowing down child vaccination progress in Africa

Mistrust in local and national governments is slowing down child vaccination progress in Africa, which has half of the world's unvaccinated and undervaccinated children, a study shows.

20 May 2021

Stark racial disparities persist in vaccinations, state-level CDC data shows

Black Americans’ covid-19 vaccination rates are still lagging months into the nation's campaign, while Hispanics are closing the gap and Native Americans show the highest rates overall, according to federal data obtained by KHN.

20 May 2021

Mortality News and Research

Are COVID-19 medications safe in pregnancy?

How conservative are the current COVID-19 pandemic global statistics?

Higher BMI linked to higher survival rates in patients hospitalized for severe bacterial infections

Which biomarkers can help predict adverse outcomes in COVID-19?

Study indicates that certain anti-cancer therapies may hasten cellular aging

Researchers identify aluminum hydroxide/TLR9 agonist as potential adjuvant to improve RBD-based COVID-19 vaccine efficacy

Decreasing activity of ZMPSTE24 protease with age and comorbidities may make elderly COVID-19 patients vulnerable

SARS-CoV-2 virus persistence in immunocompromised individuals

Landmark study confirms that controlled blood pressure is key to prevent stroke, heart disease

Risk factors for rare COVID-19 complications in children (MIS-C)

Nearly 1 million more deaths relating to COVID-19 occurred in high-income countries

Despite frequent vaccinations, COVID-19 could continue to cause recurrent waves and deaths

Metal complexes against coronavirus

Total COVID-19 deaths in US counties have been underestimated by 20%, indicates study

North America has 87% of all unique SARS-CoV-2 S protein variants in the NCBI database among six continents

Intranasal COVID-19 therapeutic shows promise in preclinical trials

Blocking TGFβ1 could improve hematopoiesis in AML patients, indicates study

Phase 3 trial: New biologic therapy improves outcomes in adults, adolescents with severe asthma

Mistrust in local, national governments is slowing down child vaccination progress in Africa

Stark racial disparities persist in vaccinations, state-level CDC data shows

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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