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Transcription of genes is fast but sloppy in old age

In a large joint project, a total of six research groups from the University of Cologne Cluster of Excellence on Cellular Stress Responses in Age-Associated Diseases (CECAD), the Max Planck Institute for Biology of Aging (MPI) in Cologne and the University of Göttingen have demonstrated the following findings which apply across the animal kingdom: with increasing age, the transcriptional elongation speed of genes increases, whereby the quality of the gene products suffers.

12 Apr 2023

Optimized genome-editing method opens the door to more effective treatment of genetic diseases

CRISPR-Cas9 is widely used to edit the genome by studying genes of interest and modifying disease-associated genes.

11 Apr 2023

Study finds mobile antibiotic resistance genes in some probiotic bacteria, raising concerns for public health

Researchers examine antibiotic resistance genes and their mobility in Bifidobacteriales and Lactobacillales species.

11 Apr 2023

Exploring the tantalizing questions about sleep

Sleep is one of the most essential human activities - so essential, in fact, that if we don't get enough sleep for even one night, we may struggle to think, react, and otherwise make it through the day.

11 Apr 2023

Bonn researchers elucidate a mechanism underlying cisplatin resistance in testicular cancer

Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative therapy options.

11 Apr 2023

Mutant Salmonella strains cause more severe infections than wild-type bacteria in chickens

In Brazil, a group of researchers supported by FAPESP created mutant forms of Salmonella to understand the mechanisms that favor colonization of the intestinal tract of chickens by these pathogenic bacteria and find better ways to combat the infection they cause.

11 Apr 2023

Study to measure the impact of whole genome sequencing in patients with cardiovascular disease

Henry Ford Health research teams are launching a series of clinical studies in partnership with Illumina Inc., a global leader in DNA sequencing and array-based technologies, to assess the impact of comprehensive genomic testing in various disease areas.

11 Apr 2023

Dietary supplement N-acetylcysteine helps overcome treatment resistance in breast cancer

Many cancer therapies do not produce the hoped-for results. A common reason for this is that the tumors develop resistance to the medication.

11 Apr 2023

Study expands the knowledge about gut viral diversity in healthy infants

Viruses are usually associated with illness. But our bodies are full of both bacteria and viruses that constantly proliferate and interact with each other in our gastrointestinal tract.

11 Apr 2023

Using tiny bubbles to improve gene therapy

Beyond vaccines, mRNA offers immense potential to fight disease, but targeting the genetic material to specific diseased cells is challenging - requiring a new method.

11 Apr 2023

The Parkinson's Pandemic: from the importance of early diagnosis to digital solutions

News Medical spoke to Michele Hu, Consultant Neurologist at Oxford University Hospitals and Professor of Clinical Neuroscience at the Nuffield Department of Clinical Neurosciences, University of Oxford, about prodromal Parkinson's and what the future looks like for this neurological disease.

11 Apr 2023

The association between adiposity and cognitive function

Researchers assessed the associations between cognitive function and adiposity.

11 Apr 2023

Study finds higher BMI and smoking increased time to conception

Researchers evaluate the effect of lifestyle behaviors on various fertility and reproductive outcomes.

10 Apr 2023

The emergence of tanapox in South Africa, 2022

Study describes a human case of tanapox in South Africa.

10 Apr 2023

Immunotherapy response in patients with advanced melanoma depends on prior treatments

Research led by scientists at UCLA Jonsson Comprehensive Cancer Center found that responses to a type of immunotherapy called PD-1 checkpoint blockade in patients with advanced melanoma depended on whether or not they had previously received another immunotherapy – CTLA-4 blockade – as well as other factors.

10 Apr 2023

Is there an association between body mass index and cognitive function in older adults?

Researchers examined whether body mass index was associated with cognitive performance in older adults.

10 Apr 2023

New finding in roundworms upends classical thinking about animal cell differentiation

Researchers have spotted how specific proteins within the chromosomes of roundworms enable their offspring to produce specialized cells generations later, a startling finding that upends classical thinking that hereditary information for cell differentiation is mostly ingrained within DNA and other genetic factors.

7 Apr 2023

Genetic discovery may pave the way for precision medicine approaches to treat depression

A team of scientists at the Medical University of South Carolina (MUSC) has identified a stress-regulated gene that plays a role in the link between long-term stress and a common type of depressive behavior in mice.

7 Apr 2023

New method estimates mutation risks due to residual radiation from the Fukushima nuclear disaster

Ionizing radiation from nuclear disasters are known to be harmful to the natural environment. The Fukushima Dai-ichi Nuclear Power Plant meltdown that occurred in 2011 is a prominent example of such a disaster in recent memory.

7 Apr 2023

New report seeks to uncover attitudes, challenges facing colorectal cancer awareness and screening

To uncover attitudes and the biggest challenges facing colorectal cancer (CRC) awareness and screening, BGI Genomics today released its State of Colorectal Cancer Awareness Report, marking the first-ever global survey report on the world's third most common cancer.

7 Apr 2023

Genetic News and Research

Transcription of genes is fast but sloppy in old age

Optimized genome-editing method opens the door to more effective treatment of genetic diseases

Study finds mobile antibiotic resistance genes in some probiotic bacteria, raising concerns for public health

Exploring the tantalizing questions about sleep

Bonn researchers elucidate a mechanism underlying cisplatin resistance in testicular cancer

Mutant Salmonella strains cause more severe infections than wild-type bacteria in chickens

Study to measure the impact of whole genome sequencing in patients with cardiovascular disease

Dietary supplement N-acetylcysteine helps overcome treatment resistance in breast cancer

Study expands the knowledge about gut viral diversity in healthy infants

Using tiny bubbles to improve gene therapy

The Parkinson's Pandemic: from the importance of early diagnosis to digital solutions

The association between adiposity and cognitive function

Study finds higher BMI and smoking increased time to conception

The emergence of tanapox in South Africa, 2022

Immunotherapy response in patients with advanced melanoma depends on prior treatments

Is there an association between body mass index and cognitive function in older adults?

New finding in roundworms upends classical thinking about animal cell differentiation

Genetic discovery may pave the way for precision medicine approaches to treat depression

New method estimates mutation risks due to residual radiation from the Fukushima nuclear disaster

New report seeks to uncover attitudes, challenges facing colorectal cancer awareness and screening

Sequencing & Genomics: Elevating Science and Healthcare eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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