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Targeted molecular therapy reduces initial development of NAFLD in mice

Researchers report in the journal Cell Reports a targeted molecular therapy that dramatically reduces the initial development of Non Alcoholic Fatty Liver Disease (NAFLD) in laboratory mouse models of the disease.

1 Jul 2016

CVD researchers to use minimally invasive tissue sampling to identify cause of child mortality

The Center for Vaccine Development has been awarded a large grant for research that will help determine why so many children under five are dying in the world's poorest countries.

1 Jul 2016

Researchers develop in vitro model system for investigating etiology of NAFLD

Researchers from the Institute for Stem Cell Research and Regenerative Medicine at the University Clinic of Düsseldorf have established an in vitro model system for investigating nonalcoholic fatty liver disease (NAFLD).

30 Jun 2016

Experts compile model list of essential diagnostic tests aiming to improve global health

In a western doctor's office or hospital, patients don't think twice about giving a blood or urine sample that can tell if they have a disease or infection, or show if their medicines are working. The samples get rushed to a testing lab with modern equipment that's held to high quality standards.

30 Jun 2016

Alcohol intoxication perturbs immune system of aged individuals

The immune system in the elderly is dysfunctional and infections are more prevalent, more severe, and harder to defeat. Drinking alcohol has a variety of damaging effects on the immune system and organs - like the gut, liver and lung - which can be worsened by pre-existing conditions as well as consumption of prescription and over-the-counter medications that aged individuals often take.

28 Jun 2016

Epclusa drug receives FDA approval for treating adult patients with chronic HCV

The U.S. Food and Drug Administration approved Epclusa to treat adult patients with chronic hepatitis C virus (HCV) both with and without cirrhosis (advanced liver disease).

28 Jun 2016

Pioglitazone effective in diabetes patients with NASH

Pioglitazone may halt the progression of nonalcoholic steatohepatitis in patients with prediabetes or Type 2 diabetes, a randomised trial shows.

28 Jun 2016

Eye donations: what stops people? An interview with Rory Passmore

Despite a shortage of corneas for transplant purposes, our new research reveals that eyes are the one body part we are least likely to donate.

27 Jun 2016

Blood mannose levels could help predict type 2 diabetes risk

Even if you are not overweight, your mannose levels may indicate whether you're at risk for type 2 diabetes (T2D) or insulin resistance (IR), a Swedish study shows.

27 Jun 2016

MLDA of 21 appears to protect against alcohol-related mortality later in life

The minimum legal drinking age (MLDA) in the U.S. regulates the age at which individuals can legally purchase and possess alcohol in public. An MLDA of 21 has been linked to a number of benefits, including a lower risk for alcoholism in adulthood.

25 Jun 2016

Novel method uses lasers to carve paths inside biocompatible gels

Future medicine is bound to include extensive tissue-engineering technologies such as organs-on-chips and organoids - miniature organs grown from stem cells. But all this is predicated on a simple yet challenging task: controlling cellular behavior in three dimensions.

23 Jun 2016

Scientists streamline total synthesis of uncialamycin drug

A team led by Rice University scientists has improved the production of a potent anti-tumor antibiotic known as uncialamycin.

23 Jun 2016

Researchers identify candidate genes controlling phenolic compound accumulation in broccoli

Love it or hate it, broccoli is touted as a superfood, offering an array of health benefits. And it's about to get even more super.

23 Jun 2016

Maternal HBsAg can serve as HBV vertical transmission marker

Two studies have independently identified quantitative hepatitis B surface antigen as a marker to identify pregnant women with chronic hepatitis B virus infection whose infants are at high-risk of infection despite immunoprophylaxis.

23 Jun 2016

Novel combination therapy slows cancer growth in patients with advanced solid tumors

A phase 1 clinical trial testing a novel combination therapy developed by scientists at VCU Massey Cancer Center slowed the growth of cancer in the majority of trial participants, which were patients with advanced solid tumors.

22 Jun 2016

New magnetically controlled drug safe, effective in dissolving blood clots

Critical conditions associated with the blockage of blood vessels are one of the primary health concerns worldwide.

22 Jun 2016

Paclitaxel drug may promote cancer spread at low doses

New research indicates that paclitaxel, which is the most commonly used chemotherapy for breast cancer, suppresses tumors when given at a certain dosage, but at low doses, it actually promotes cancer spread to the liver.

22 Jun 2016

Salvage inotuzumab ozogamicin improves ALL outcomes

Compared with standard chemotherapy, treatment with inotuzumab ozogamicin increases the rate of complete remission and allows a higher proportion of patients with relapsed or refractory acute lymphoblastic leukaemia to subsequently receive stem-cell transplantation, research suggests.

22 Jun 2016

Study shows Alzheimer's disease can lead to diabetes

Drugs used to treat diabetes could also be used to treat Alzheimer's disease, and vice versa, according to new research from the University of Aberdeen.

21 Jun 2016

Clinical trial finds pioglitazone drug safe and effective for NASH patients

Researchers have found that an existing diabetes drug can be used to halt progression of another disease that is a leading cause of liver transplants.

21 Jun 2016