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AI unlocks secrets of gastric cancer development

Gastric cancer, a significant global health challenge, is characterized by a complex transition from inflammation-induced premalignant lesions to malignancy. The quest for early diagnosis and prevention is impeded by the intricate biological shifts that mark this journey, highlighting an urgent need for a deeper dive into the underlying the multi-level and dynamic features.

8 Aug 2024

Discovery of progenitor exhausted T cells offers hope for cancer patients

Tumor immunotherapy leverages the body's immune system to target and eradicate cancer cells, offering a crucial treatment for patients unresponsive to surgery or conventional therapies. Despite its potential, the effectiveness of immunotherapy is often hindered by T cell exhaustion within the tumor microenvironment, leading to diminished immune response and tumor progression. Based on these challenges, exploring the role of progenitor exhausted T cells (Tpex) in overcoming immune resistance is essential for advancing immunotherapeutic strategies and improving clinical outcomes.

8 Aug 2024

Cross-reactive T cells link SARS-CoV-2 to autoimmune triggers in MIS-C

Research identifies cross-reactive T cells targeting both SARS-CoV-2 and human SNX8 protein, providing insights into the autoimmune mechanisms driving MIS-C in children.

8 Aug 2024

New insights into topoisomerase I inhibition reveal potential pathways for cancer therapies

A research group at the University of Bologna has identified, for the first time, the specific location and genomic context where DNA breaks occur due to the inhibition of the topoisomerase I, a protein crucial for many biological processes in cells.

8 Aug 2024

Study links renalase-1 and T-cell receptor interaction to increased melanoma survival

A new research paper was published in Oncotarget's Volume 15 on August 5, 2024, entitled, "Chemical complementarity of tumor resident, T-cell receptor CDR3s and renalase-1 correlates with increased melanoma survival."

8 Aug 2024

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced ISM6331, potential best-in-class pan-TEAD inhibitor, has received the U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) clearance for the treatment of mesothelioma, following the grant of Orphan Drug Designation (ODD) in June 2024. It brings the total number of IND-approved molecules of Insilico to nine.

8 Aug 2024

Breakthrough discovery could boost stem-cell transplants by improving cell mobilization

A discovery by a three-member Albert Einstein College of Medicine research team may boost the effectiveness of stem-cell transplants, commonly used for patients with cancer, blood disorders, or autoimmune diseases caused by defective stem cells, which produce all the body's different blood cells.

8 Aug 2024

Gene activity can predict severe side effects from melanoma treatment

An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases can predict which melanoma patients are likely to have severe side effects from immunotherapy designed to treat the most deadly skin cancer, a new study shows.

8 Aug 2024

ProDOL revolutionizes protein quantification in living cells

Scientists have developed a new way of counting labeled proteins in living cells that could become a standard and valuable tool in the field of biomedical research.

8 Aug 2024

Individualized neoantigen cancer therapy demonstrates safety and efficacy in early trials

For decades, researchers have worked to develop therapies that can prime the immune system to recognize and attack proteins on the surface of tumor cells.

8 Aug 2024

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Using zebrafish "Avatars", an animal model developed by the Cancer Development and Innate Immune Evasion lab at the Champalimaud Foundation (CF), led by Rita Fior, Mayra Martínez-López – a former PhD student at the lab now working at the Universidad de las Américas in Quito, Ecuador – and colleagues studied the initial steps of the Bacillus Calmette-Guérin (BCG) vaccine's action on bladder cancer cells.

8 Aug 2024

Review of fasting-mimicking diets in cancer treatment

Researchers present the role of cyclic fasting and fasting-mimicking diets (FMD) in cancer therapy.

8 Aug 2024

Consuming foods with erythritol increases risk of cardiovascular events, study shows

New Cleveland Clinic research shows that consuming foods with erythritol, a popular artificial sweetener, increases risk of cardiovascular events such as heart attack and stroke.

8 Aug 2024

New $11.3 million grant to explore endothelial cell dysfunction in cardiovascular disease

With a new $11.3 million Program Project grant from the National Institutes of Health, experts from the Vascular Biology Center at the Medical College of Georgia at Augusta University are working to better understand the underlying mechanisms of cardiovascular disease.

8 Aug 2024

High BPA levels linked to increased prostate cancer risk in older men

A study in Nutrients found that higher urinary bisphenol A (BPA) levels are linked to increased prostate-specific antigen (PSA) and higher prostate cancer risk in senior American men. This suggests a need for heightened cancer screening, especially in high-risk groups.

8 Aug 2024

New method advances the creation of implantable human organs

Growing functional human organs outside the body is a long-sought "holy grail" of organ transplantation medicine that remains elusive.

7 Aug 2024

How C. elegans uses smell to preemptively guard against pathogen attacks

Many organisms react to the smell of deadly pathogens by reflexively avoiding them. But a recent study from the University of California, Berkeley, shows that the nematode C. elegans also reacts to the odor of pathogenic bacteria by preparing its intestinal cells to withstand a potential onslaught.

7 Aug 2024

Cell News and Research

AI unlocks secrets of gastric cancer development

Discovery of progenitor exhausted T cells offers hope for cancer patients

Cross-reactive T cells link SARS-CoV-2 to autoimmune triggers in MIS-C

New insights into topoisomerase I inhibition reveal potential pathways for cancer therapies

Study links renalase-1 and T-cell receptor interaction to increased melanoma survival

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Breakthrough discovery could boost stem-cell transplants by improving cell mobilization

Gene activity can predict severe side effects from melanoma treatment

ProDOL revolutionizes protein quantification in living cells

Individualized neoantigen cancer therapy demonstrates safety and efficacy in early trials

Zebrafish model reveals how BCG vaccine triggers immune response in bladder cancer

Review of fasting-mimicking diets in cancer treatment

Consuming foods with erythritol increases risk of cardiovascular events, study shows

New $11.3 million grant to explore endothelial cell dysfunction in cardiovascular disease

High BPA levels linked to increased prostate cancer risk in older men

New method advances the creation of implantable human organs

How C. elegans uses smell to preemptively guard against pathogen attacks

SARS-CoV-2 protein linked to onset of multisystem inflammatory syndrome in children

New treatment boosts pluripotent stem cell production in mice

New stem cell therapy for heart failure undergoing U.S. clinical trials

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