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Surgeons develop 'monoblock' flaps to reconstruct severe facial defects

Patients with massive burns causing complete loss of the facial skin pose a difficult challenge for reconstructive surgeons. Now a group of surgeons in China have developed an innovative technique for creating a one-piece skin flap large enough to perform full-face resurfacing, reports The Journal of Craniofacial Surgery, published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health.

6 Feb 2014

Chemical "signature" in blood may predict which AML patients would benefit from chemotherapy

Researchers at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center have found a chemical "signature" in blood-forming stem cells that predicts whether patients with acute myeloid leukemia (AML) will respond to chemotherapy.

4 Feb 2014

Surgeons report safer method to replace bone removed from skull after lifesaving brain surgery

Johns Hopkins surgeons report they have devised a better, safer method to replace bone removed from the skull after lifesaving brain surgery. The new technique, they say, appears to result in fewer complications than standard restoration, which has changed little since its development in the 1890s.

4 Feb 2014

High sodium intake correlates with fatness and inflammation in adolescents

Most adolescents consume as much salt as adults - some more than twice the recommended daily allowance - and that high sodium intake correlates with fatness and inflammation regardless of how many calories they consume, researchers report.

3 Feb 2014

FDA grants Breakthrough Therapy designation to GSK's Promacta/Revolade for treatment of cytopenias

Ligand Pharmaceuticals Incorporated today announced that the U.S. Food and Drug Administration has granted its partner GlaxoSmithKline plc Breakthrough Therapy designation for Promacta/Revolade (eltrombopag) for the treatment of cytopenias in patients with severe aplastic anemia (SAA) who have had insufficient response to immunosuppressive therapy.

3 Feb 2014

Dormant prostate cancer cells in bone tissue can be reawakened, say researchers

Researchers in the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute discovered in pre-clinical models that dormant prostate cancer cells found in bone tissue can be reawakened, causing metastasis to other parts of the body. Understanding this mechanism of action may allow researchers to intervene prior to disease progression.

31 Jan 2014

New study reveals way to combat drug-resistant tumors

Cancer drugs that recruit antibodies from the body's own immune system to help kill tumors have shown much promise in treating several types of cancer. However, after initial success, the tumors often return.

31 Jan 2014

Study describes new tack in treatment of lung adenocarcinomas

The most common genetic subtype of lung cancer, which has long defied treatment with targeted therapies, has had its growth halted by a combination of two already-in-use drugs in laboratory and animal studies, setting the stage for clinical trials of the drugs in patients, researchers at Dana-Farber Cancer Institute and other scientists report in a new study.

31 Jan 2014

Finding could lead to new treatments for osteoporosis

Scientists at Washington University School of Medicine in St. Louis have discovered what appears to be a potent stimulator of new bone growth. The finding could lead to new treatments for osteoporosis and other diseases that occur when the body doesn't make enough bone.

31 Jan 2014

Biologists open new window on natural process of bone regeneration in zebra fish

University of Oregon biologists say they have opened the window on the natural process of bone regeneration in zebra fish, and that the insights they gained could be used to advance therapies for bone fractures and disease.

30 Jan 2014

CTI announces initiation of pacritinib Phase 2 trial in AML patients with FLT3 mutations

Cell Therapeutics, Inc. today announced the initiation of an international cooperative group Phase 2 clinical trial of pacritinib in adult patients with relapsed acute myeloid leukemia (AML) with mutations of the FLT3 gene. Mutation of the FLT3 gene is found in approximately one-third of AML patients and is an independent risk factor for poor prognosis.

30 Jan 2014

Dormant prostate cancer cells within bone tissue can be reawakened to a cancerous state

Dormant prostate cancer cells in bone tissue can be reawakened to cause secondary tumours, according to new research published in Endocrine-Related Cancer. Targeting the wake-up call could prevent metastasis and improve prostate cancer survival rates.

29 Jan 2014

Allogeneic transplants via Blood/Marrow Transplant Program show better outcomes

For the fourth consecutive year, outcomes for patients receiving allogeneic transplants through the Blood and Marrow Transplant Program at Roswell Park Cancer Institute (RPCI) have been shown to be significantly better than would be expected among the patient population treated.

29 Jan 2014

Scientists develop automated system that identifies high-risk osteoporosis patients

An automated system that identifies high-risk osteoporosis patients being treated for fractures and can generate letters encouraging follow-up is an effective way to promote osteoporosis intervention and prevent future fractures, according to Penn State College of Medicine researchers.

29 Jan 2014

Staged surgery for most complex cases of childhood epilepsy

A staged approach to epilepsy surgery-with invasive brain monitoring followed by surgery in a single hospital stay-is a safe and beneficial approach to treatment for complex cases of epilepsy in children, reports the February issue of Neurosurgery, official journal of the Congress of Neurological Surgeons.

28 Jan 2014

Women with vitamin D deficiency during pregnancy may be at risk of developing severe preeclampsia

Women who are deficient in vitamin D in the first 26 weeks of their pregnancy may be at risk of developing severe preeclampsia, a potentially life-threatening disorder diagnosed by an increase in blood pressure and protein in the urine, according to research by the University of Pittsburgh Graduate School of Public Health.

28 Jan 2014

Study demonstrates direct effects of fragmented sleep on tumor growth

Poor-quality sleep marked by frequent awakenings can speed cancer growth, increase tumor aggressiveness and dampen the immune system's ability to control or eradicate early cancers, according to a new study published online January 21, 2014, in the journal Cancer Research.

27 Jan 2014

Organ and tissue donation saves lives

OneLegacy, the non-profit, federally designated organ, eye and tissue recovery agency serving the seven-country greater Los Angeles area, today issued the following statement: "Kim Pham, the 23-year-old woman who died from her injuries after being assaulted outside a Santa Ana nightclub on Jan. 18, saved five lives through the donation of her heart, kidneys, lungs, pancreas and liver to patients on the national organ transplant waiting list.

27 Jan 2014

Study examines existing evidence related to health benefits of vitamin D

A new study concludes that evidence is lacking for substantial health benefits of vitamin D – and that results of several multimillion-dollar trials currently underway are unlikely to alter this view.

24 Jan 2014

Salmonella infections can reduce incidence of asthma, say researchers

Researchers from Germany have identified the mechanism by which Salmonella infections can reduce the incidence of asthma in mice. The research, which appears ahead of print in the journal Infection and Immunity, opens up new avenues of research that could lead to treatments.

24 Jan 2014

Bone News and Research

Surgeons develop 'monoblock' flaps to reconstruct severe facial defects

Chemical "signature" in blood may predict which AML patients would benefit from chemotherapy

Surgeons report safer method to replace bone removed from skull after lifesaving brain surgery

High sodium intake correlates with fatness and inflammation in adolescents

FDA grants Breakthrough Therapy designation to GSK's Promacta/Revolade for treatment of cytopenias

Dormant prostate cancer cells in bone tissue can be reawakened, say researchers

New study reveals way to combat drug-resistant tumors

Study describes new tack in treatment of lung adenocarcinomas

Finding could lead to new treatments for osteoporosis

Biologists open new window on natural process of bone regeneration in zebra fish

CTI announces initiation of pacritinib Phase 2 trial in AML patients with FLT3 mutations

Dormant prostate cancer cells within bone tissue can be reawakened to a cancerous state

Allogeneic transplants via Blood/Marrow Transplant Program show better outcomes

Scientists develop automated system that identifies high-risk osteoporosis patients

Staged surgery for most complex cases of childhood epilepsy

Women with vitamin D deficiency during pregnancy may be at risk of developing severe preeclampsia

Study demonstrates direct effects of fragmented sleep on tumor growth

Organ and tissue donation saves lives

Study examines existing evidence related to health benefits of vitamin D

Salmonella infections can reduce incidence of asthma, say researchers

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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