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Biologists discover new pathway for repairing nerve cells

Penn State University molecular biologists have discovered a brand-new pathway for repairing nerve cells that could have implications for faster and improved healing. The researchers describe their findings in a paper titled "Dendrite injury triggers DLK-independent regeneration," which will be published in the 30 January 2014 issue of the journal Cell Reports.

10 Jan 2014

Researchers develop personalized tool to predict likelihood of prostate cancer overdiagnosis

Studies have found that prostate cancer is overdiagnosed in up to 42 percent of cases, prompting men to receive unnecessary treatment that can cause devastating side effects, including impotence and incontinence.

9 Jan 2014

Biogen Idec, Sangamo BioSciences partner to develop therapeutics for hemoglobinopathies

Biogen Idec and Sangamo BioSciences, Inc. announced today an exclusive worldwide collaboration and license agreement focused on the development of therapeutics for hemoglobinopathies, inherited conditions that result from the abnormal structure or underproduction of hemoglobin.

9 Jan 2014

Auxilium Pharmaceuticals reports interim data from XIAFLEX Phase 4 study in patients with DC

Auxilium Pharmaceuticals, Inc., a fully integrated specialty biopharmaceutical company, today announced that interim data from its Phase 4 retreatment study (AUX-CC-862) evaluating XIAFLEX (collagenase clostridium histolyticum or CCH) in adult patients with Dupuytren's contracture and a recurrent contracture with a palpable cord will be presented for the first time at the American Association for Hand Surgery 2014 Annual Meeting being held January 8-11, 2014 in Kauai, Hawaii.

9 Jan 2014

Immune tolerance to grafts of muscle, bone and skin could free recipients from lifelong immunosuppression

Massachusetts General Hospital investigators have made an important step towards greater availability of hand transplants, face transplants and other transplants involving multiple types of tissue.

9 Jan 2014

Researchers use stem cells to study bone disorders from patients afflicted with genetic bone disease

Researchers have developed a new way to study bone disorders and bone growth, using stem cells from patients afflicted with a rare, genetic bone disease.

9 Jan 2014

Teleflex includes Vidacare vascular products in ARROW Vascular Access family

Teleflex Incorporated, a leading global provider of medical devices for critical care and surgery, will be showcasing ARROW Vascular Products along with the newly acquired Vidacare vascular product line at the annual Society of Critical Care Medicine, January 9-13 in San Francisco, California.

9 Jan 2014

Implantation of sleep apnea device can lead to improvements for patients with OSA

Implantation of a sleep apnea device called Inspire- Upper Airway Stimulation therapy can lead to significant improvements for patients with obstructive sleep apnea, according to a study published today in the New England Journal of Medicine.

9 Jan 2014

NYSCF and ISMMS scientists successfully generate stem cell model of familial Alzheimer's disease

Scientists at The New York Stem Cell Foundation Research Institute in collaboration with scientists at the Icahn School of Medicine at Mount Sinai successfully generated a stem cell model of familial Alzheimer's disease.

8 Jan 2014

IDMC recommends early stopping of Phase 3 study of ibrutinib in treatment of CLL/SLL

Janssen-Cilag International NV today announced the early stopping of PCYC-1112-CA, the Phase 3 study of ibrutinib in the treatment of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma, based on the recommendation of an Independent Data Monitoring Committee, which concluded that the study showed a significant difference in progression-free survival as compared to the control, the primary endpoint of the study.

8 Jan 2014

Notre Dame, Loyola partner to provide direct support for revolutionary new cancer research

Two research powerhouses, Loyola University Chicago and the University of Notre Dame, are joining forces in a multidisciplinary cancer research collaboration.

8 Jan 2014

Lower bone strength may predispose children to factures resulting from weakened later in life

Broken bones may seem like a normal part of an active childhood. About 1 in 3 otherwise healthy children suffers a bone fracture. Breakage of the bone running from the elbow to the thumb side of the wrist (distal forearm fracture) is the most common.

8 Jan 2014

Study shows ability to make living human cells from biobanked brain tissue of Alzheimer's patients

Scientists at The New York Stem Cell Foundation (NYSCF) Research Institute, working in collaboration with scientists from Columbia University Medical Center (CUMC), for the first time generated induced pluripotent stem (iPS) cells lines from non-cryoprotected brain tissue of patients with Alzheimer's disease.

7 Jan 2014

FDA accepts NPS Pharmaceuticals' Natpara BLA for review

NPS Pharmaceuticals, Inc., a global biopharmaceutical company pioneering and delivering therapies that transform the lives of patients with rare diseases worldwide, today announced that the U.S. Food and Drug Administration has accepted and filed for review the company's Biologics License Application for Natpara (recombinant human parathyroid hormone 1-84, (rhPTH[1-84])) for the treatment of hypoparathyroidism.

7 Jan 2014

EC grants approval for ABRAXANE in combination with gemcitabine for metastatic pancreatic cancer

Celgene International Sàrl, a wholly-owned subsidiary of Celgene Corporation, today announced that the European Commission has granted approval for ABRAXANE (paclitaxel formulated as albumin bound nanoparticles, or nab-paclitaxel) in combination with gemcitabine for first-line treatment of adult patients with metastatic adenocarcinoma of the pancreas, or metastatic pancreatic cancer.

7 Jan 2014

DePuy Synthes Spine announces the U.S. launch of new tissue implant for spine fusion surgery

DePuy Synthes Spine, in collaboration with DePuy Synthes Biomaterials, announced today the U.S. launch of CONFORM SHEET, a hydrated, pliable and totally demineralized cancellous bone matrix that fills voids during posterolateral spinal fusion surgery and provides a natural scaffold for new bone formation.

7 Jan 2014

DePuy Synthes develops CONFORM SHEET allograft implant for spinal fusion surgery

DePuy Synthes Spine, in collaboration with DePuy Synthes Biomaterials, announced today the U.S. launch of CONFORM SHEET™, a hydrated, pliable and totally demineralized cancellous bone matrix that fills voids during posterolateral spinal fusion surgery and provides a natural scaffold for new bone formation.

7 Jan 2014

Aeterna Zentaris announces FDA acceptance for filing of macimorelin acetate NDA for AGHD

Aeterna Zentaris Inc. today announced that the U.S. Food and Drug Administration has accepted for filing the Company's New Drug Application for its ghrelin agonist, macimorelin acetate, in Adult Growth Hormone Deficiency. The acceptance for filing of the NDA indicates the FDA has determined that the application is sufficiently complete to permit a substantive review.

7 Jan 2014

Diet high in fibre may ward off asthma

The Western diet probably has more to do with the asthma epidemic than has been assumed so far because developing asthma is related to the amount of fruit and vegetables consumed. Gut bacteria ferment the dietary fibres contained in them and fatty acids enter the blood as a result, influencing the immune response in the lungs. This has been shown by a research project funded by the Swiss National Science Foundation (SNSF).

6 Jan 2014

New clinical report provides guidance on overuse injuries and burnout in young athletes

As an emphasis on competitive success in youth sports has led to intense training, frequent competition and early single sport specialization, overuse injuries and burnout have become common.

6 Jan 2014

Bone News and Research

Biologists discover new pathway for repairing nerve cells

Researchers develop personalized tool to predict likelihood of prostate cancer overdiagnosis

Biogen Idec, Sangamo BioSciences partner to develop therapeutics for hemoglobinopathies

Auxilium Pharmaceuticals reports interim data from XIAFLEX Phase 4 study in patients with DC

Immune tolerance to grafts of muscle, bone and skin could free recipients from lifelong immunosuppression

Researchers use stem cells to study bone disorders from patients afflicted with genetic bone disease

Teleflex includes Vidacare vascular products in ARROW Vascular Access family

Implantation of sleep apnea device can lead to improvements for patients with OSA

NYSCF and ISMMS scientists successfully generate stem cell model of familial Alzheimer's disease

IDMC recommends early stopping of Phase 3 study of ibrutinib in treatment of CLL/SLL

Notre Dame, Loyola partner to provide direct support for revolutionary new cancer research

Lower bone strength may predispose children to factures resulting from weakened later in life

Study shows ability to make living human cells from biobanked brain tissue of Alzheimer's patients

FDA accepts NPS Pharmaceuticals' Natpara BLA for review

EC grants approval for ABRAXANE in combination with gemcitabine for metastatic pancreatic cancer

DePuy Synthes Spine announces the U.S. launch of new tissue implant for spine fusion surgery

DePuy Synthes develops CONFORM SHEET allograft implant for spinal fusion surgery

Aeterna Zentaris announces FDA acceptance for filing of macimorelin acetate NDA for AGHD

Diet high in fibre may ward off asthma

New clinical report provides guidance on overuse injuries and burnout in young athletes

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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