Enzyme News and Research

RSS

Epigenetic changes favor development of fatty liver in humans and mice

Mice with a strong tendency to obesity already exhibit epigenetic changes at six weeks of age, inducing the liver to amplify its production of the enzyme DPP4 and release it into the circulation. Over the long term, this favors the development of a fatty liver.

9 Jan 2017

UI scientists reveal how high-dose vitamin C damages cancer cells

Vitamin C has a patchy history as a cancer therapy, but researchers at the University of Iowa believe that is because it has often been used in a way that guarantees failure.

9 Jan 2017

Penn study finds evidence of AD neuropathology in post-mortem brains of LBD patients

Patients who had a diagnosis of Parkinson's disease (PD) with dementia (PDD) or dementia with Lewy bodies (DLB) and had higher levels of Alzheimer's disease (AD) pathology in their donated post-mortem brains also had more severe symptoms of these Lewy body diseases (LBD) during their lives, compared to those whose brains had less AD pathology, according to research from the Perelman School of Medicine at the University of Pennsylvania.

6 Jan 2017

Houston Methodist researchers advance potential treatment for metaplastic breast cancer

Houston Methodist Hospital researchers have advanced a potential treatment for metaplastic breast cancer--the most aggressive subtype of triple negative breast cancer, into patients in just under four years.

6 Jan 2017

TSRI biologists uncover new mechanism behind sense of touch

Biologists on the Florida campus of The Scripps Research Institute have discovered a new mechanism that likely underlies how we feel force or touch. Their study suggests that "rafts" of fatty lipids on the cell surface act as compartments to keep certain enzymes from mixing with their binding partners.

6 Jan 2017

Experimental treatment approach reverses cognitive decline and neuropathology in AD mouse model

Treatment with an inhibitor of 12/15-lipoxygenase, an enzyme elevated in patients with Alzheimer's disease (AD), reverses cognitive decline and neuropathology in an AD mouse model, reports a new study in Biological Psychiatry.

5 Jan 2017

TSRI scientists develop new tool to uncover molecular details of protein structure

Scientists on the Florida campus of The Scripps Research Institute have developed a new tool for studying the molecular details of protein structure.

5 Jan 2017

Scientists use pluripotent stem cells to generate human stomach tissues in laboratory

Scientists report in Nature using pluripotent stem cells to generate human stomach tissues in a petri dish that produce acid and digestive enzymes.

5 Jan 2017

Researchers uncover reason for stent failure in diabetic patients with clogged arteries

People with any form of diabetes are at greater risk of developing cardiovascular conditions than people without the disease. Moreover, if they undergo an operation to open up a clogged artery by inserting a "stent" surgical tube, the artery is much more likely to clog up again.

4 Jan 2017

Scientists harness therapeutic effects of CO-RMs to develop new antibiotic for gonorrhoea

Scientists at the University of York have harnessed the therapeutic effects of carbon monoxide-releasing molecules to develop a new antibiotic which could be used to treat the sexually transmitted infection gonorrhoea.

4 Jan 2017

Scientists reveal chemical process behind anti-cancer properties of spicy pepper plant

UT Southwestern Medical Center scientists have uncovered the chemical process behind anti-cancer properties of a spicy Indian pepper plant called the long pepper, whose suspected medicinal properties date back thousands of years.

4 Jan 2017

MMP9 enzyme could suppress tumors in colitis associated cancer, new study finds

An enzyme that plays an active role in inflammation could be a natural way to suppress tumors and ulcers in the colon that are found in colitis associated cancer (CAC), a type of colorectal cancer that is driven by chronic inflammation, according to a new study.

3 Jan 2017

AMPK enzyme plays vital role in enhancing muscle insulin sensitivity after physical activity

ampk Physical activity benefits diabetics and others with insulin resistance. One of the reasons is that a single bout of physical activity increases the effectiveness of insulin.

3 Jan 2017

Persistent infection in infant reveals mutation that helps bacteria tolerate antibiotic therapy

The quest to understand a prolonged infection in an infant being treated for leukemia has led to the St. Jude Children's Research Hospital discovery of a mutation that allows bacteria to tolerate normally effective antibiotic therapy. The report appears today in the scientific journal mBio.

3 Jan 2017

Researchers create molecules with potential to deliver healing power to stressed cells

Molecules with the potential to deliver healing power to stressed cells - such as those involved in heart attacks - have been created by University of Oregon researchers.

30 Dec 2016

Research reveals how microbial context during infectious disease can compromise antibiotic therapy

Bacteria that are susceptible to antibiotics can survive when enough resistant cells around them are expressing an antibiotic-deactivating factor.

28 Dec 2016

New database of PCR primers enables effective detection and identification of RNA viruses

Scientists at Korea's Daegu Gyeongbuk Institute of Science and Technology scientists have compiled a comprehensive new public database of genetic information to enable the detection and identification of RNA viruses using the polymerase chain reaction assay.

28 Dec 2016

Novel murine model helps shed light on mechanisms involved in reversible infantile liver failure

Reversible infantile liver failure (RILF) is a heritable mitochondrial condition that causes severe liver dysfunction in infancy, but those who survive the acute stage typically recover and have no further problems.

27 Dec 2016

Scientists identify sugar molecule that reduces inflammatory response and COPD progression

Using a mouse model, scientists from the RIKEN-Max Planck Joint Research Center for Systems Chemical Biology and a number of other institutes have identified a sugar molecule that reduced the inflammatory response and progress of emphysema, a common component of chronic obstructive pulmonary disease (COPD).

27 Dec 2016

Potential drug could become first effective treatment option for Prader-Willi syndrome

Duke Health researchers have identified a drug-like small molecule that, in animal experiments, appears to be an effective treatment for a genetic disorder called Prader-Willi syndrome.

27 Dec 2016

Enzyme News and Research

Epigenetic changes favor development of fatty liver in humans and mice

UI scientists reveal how high-dose vitamin C damages cancer cells

Penn study finds evidence of AD neuropathology in post-mortem brains of LBD patients

Houston Methodist researchers advance potential treatment for metaplastic breast cancer

TSRI biologists uncover new mechanism behind sense of touch

Experimental treatment approach reverses cognitive decline and neuropathology in AD mouse model

TSRI scientists develop new tool to uncover molecular details of protein structure

Scientists use pluripotent stem cells to generate human stomach tissues in laboratory

Researchers uncover reason for stent failure in diabetic patients with clogged arteries

Scientists harness therapeutic effects of CO-RMs to develop new antibiotic for gonorrhoea

Scientists reveal chemical process behind anti-cancer properties of spicy pepper plant

MMP9 enzyme could suppress tumors in colitis associated cancer, new study finds

AMPK enzyme plays vital role in enhancing muscle insulin sensitivity after physical activity

Persistent infection in infant reveals mutation that helps bacteria tolerate antibiotic therapy

Researchers create molecules with potential to deliver healing power to stressed cells

Research reveals how microbial context during infectious disease can compromise antibiotic therapy

New database of PCR primers enables effective detection and identification of RNA viruses

Novel murine model helps shed light on mechanisms involved in reversible infantile liver failure

Scientists identify sugar molecule that reduces inflammatory response and COPD progression

Potential drug could become first effective treatment option for Prader-Willi syndrome

Measuring Drug-Target Residence Times with Biochemical Assays eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo