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Amorphous calcium phosphate drives aortic valve stiffening

The human body has sophisticated defenses against the deposition of calcium minerals that stiffen heart tissues, researchers at the University of Illinois Urbana-Champaign and collaborators at UCLA Health and the University of Texas at Austin found in a new study that provides the first detailed, step-by-step documentation of how calcification progresses.

27 Jun 2024

Adaptive therapy approach can reduce toxicity and drug resistance in ovarian cancer

Ovarian cancer, often diagnosed at an advanced stage, presents significant treatment challenges because patients tend to develop resistance to conventional therapies quickly.

26 Jun 2024

ELRIG UK and The Protein Society Partner to advance protein sciences in drug discovery

Partners to host joint conference on ‘Protein Sciences in Drug Discovery’ in Cambridge, UK from 18–19 November 2024.

From ELRIG (UK) Ltd. 26 Jun 2024

Liquid core fibers offer long-term drug delivery in medical textiles

Treating a wound or an inflammation directly where it occurs has clear advantages: The active ingredient reaches its target immediately, and there are no negative side effects on uninvolved parts of the body.

26 Jun 2024

Nonhuman primate model reveals early-stage Alzheimer’s disease progression

Research in nonhuman primates is opening the possibility of testing treatments for the early stages of Alzheimer’s and similar diseases, before extensive brain cell death and dementia set in.

26 Jun 2024

New study in rhesus macaques offers early intervention window for Alzheimer's

Research in nonhuman primates is opening the possibility of testing treatments for the early stages of Alzheimer's and similar diseases, before extensive brain cell death and dementia set in.

24 Jun 2024

Innovative SRPFM technique enables ultra-sensitive force measurement at nanoscale in fluids

Groundbreaking research has revealed a new way to measure incredibly minute forces at the nanoscale in water, pushing the boundaries of what scientists know about the microscopic world.

24 Jun 2024

How random gene activity shapes lifespan in C. elegans

Why do some people live for longer than others? The genes in our DNA sequence are important, helping avoid disease or maintain general health, but differences in our genome sequence alone explain less than 30% of the natural variance of human life expectancy.

21 Jun 2024

High-resolution structures of SSTR5 reveal key interactions with neuropeptide and drug agonists

Somatostatin receptors (SSTRs) constitute a crucial family of G protein-coupled receptors (GPCRs) that play pivotal roles in regulating hormone secretion and inhibiting tumor growth.

21 Jun 2024

Research finds microplastics in human penile tissue

The accumulation of microplastics in penile tissue to determine potential toxicity concerns.

21 Jun 2024

Study shows the critical role of time cells in complex behavioral learning

A sense of time is fundamental to how we understand, recall, and interact with the world.

19 Jun 2024

Study reveals overactive PKA protein as driver of fibrolamellar carcinoma

It's been enormously difficult to pinpoint the cause of many cancers - and many seem to have more than one origin. Fibrolamellar carcinoma (FLC), however, is one that scientists thought they had nailed down.

18 Jun 2024

Study: Hepatitis E virus may be both sexually transmitted and linked to male infertility

Discovering that hepatitis E virus is associated with sperm in pigs suggests the virus may be both sexually transmitted and linked to male infertility, according to a new study.

18 Jun 2024

Innovative 3D cell culturing method offers new insights into cancer cell mechanics

Developing chemotherapy drugs against breast cancer is costly, slow, and often inefficient, with more than 95% of screened drug candidates failing in patient trials.

14 Jun 2024

Synthetic cell mimics immune response via symmetry breaking

In a feat aimed at understanding how cells move and creating new ways to shuttle drugs through the body, scientists at Johns Hopkins Medicine say they have built a minimal synthetic cell that follows an external chemical cue and demonstrates a governing principle of biology called "symmetry breaking."

12 Jun 2024

Understanding Crohn's disease through 'mini-gut' models

Cambridge scientists have grown 'mini-guts' in the lab to help understand Crohn's disease, showing that 'switches' that modify DNA in gut cells play an important role in the disease and how it presents in patients.

10 Jun 2024

Johns Hopkins researchers discover how epilepsy drug modulates brain activity

By super cooling a molecule on the surface of brain cells down to about minus 180 degrees Celsius - nearly twice as cold as the coldest places in Antarctica - scientists at Johns Hopkins Medicine say they have determined how a widely-used epilepsy drug works to dampen the excitability of brain cells and help to control, although not cure, seizures.

10 Jun 2024