Neurological Disease News and Research

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GDF10 molecule identified as a key player in repair mechanisms after stroke

Looking at brain tissue from mice, monkeys and humans, scientists have found that a molecule known as growth and differentiation factor 10 (GDF10) is a key player in repair mechanisms following stroke. The findings suggest that GDF10 may be a potential therapy for recovery after stroke.

29 Oct 2015

Mount Sinai researchers provide a glimpse of precision medicine in action

A new publication from scientists at the Icahn School of Medicine at Mount Sinai offers a glimpse of precision medicine in action, with a massive data analysis project that identified clinically and genetically distinct subtypes of patients with type 2 diabetes. This work not only points to the possibility for more tailored diagnosis and treatment of type 2 diabetes in the future, but also reveals a novel approach that can be applied to virtually any disease.

29 Oct 2015

Study shows promise for developing targeted treatments for multiple sclerosis

Modern scientific understanding has considered multiple sclerosis (MS) to be a disease controlled by the T cell, a type of white blood cell. Research has shown that in MS, T cells inappropriately attack myelin, the protective layer of fat covering nerves in the central nervous system, exposing them to damage.

23 Oct 2015

Findings suggest a potential "early warning" detection system for Alzheimer's disease

The findings suggest a potential "early warning" detection system for Alzheimer's disease, even in young and asymptomatic individuals.

23 Oct 2015

Scientists map out the brain circuitry critical for filtering out distractions

In a study of mice, scientists discovered that a brain region called the thalamus may be critical for filtering out distractions. The study, published in Nature and partially funded by the National Institutes of Health, paves the way to understanding how defects in the thalamus might underlie symptoms seen in patients with autism, attention deficit hyperactivity disorder (ADHD), and schizophrenia.

22 Oct 2015

First patients receive doses of antisense drug for Huntington's disease

The first few patients have received doses of an experimental RNA-targeting drug for Huntington's disease, it was announced today.

20 Oct 2015

Genetic mutation linked to ALS, FTD prevents proteins from entering and exiting the cell's nucleus

Three teams of scientists supported by the National Institutes of Health showed that a genetic mutation linked to some forms of amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) may destroy neurons by disrupting the movement of materials in and out of the cell's nucleus, or command center where most of its DNA is stored.

19 Oct 2015

Genentech becomes Founding Sponsor for OPT-UP clinical study in MS, says ACP

Accelerated Cure Project for Multiple Sclerosis (ACP) announced today that Genentech, Inc., a member of the Roche Group, has become a Founding Sponsor for the Optimizing Treatment - Understanding Progression (OPT-UP) clinical study in multiple sclerosis (MS).

8 Oct 2015

MIT researchers developing computer system to help predict effects of disease on brain anatomy

MIT researchers are developing a computer system that uses genetic, demographic, and clinical data to help predict the effects of disease on brain anatomy.

7 Oct 2015

Study suggests link between human endogenous retroviral genes and ALS

Scientists at the National Institutes of Health discovered that reactivation of ancient viral genes embedded in the human genome may cause the destruction of neurons in some forms of amyotrophic lateral sclerosis (ALS).

1 Oct 2015

Study shows link between impaired mitochondria, energy failure, and neuronal dysfunction

A new study from the Gladstone Institutes shows for the first time that impairments in mitochondria--the brain's cellular power plants--can deplete cellular energy levels and cause neuronal dysfunction in a model of neurodegenerative disease.

15 Sep 2015

Scientists closer to understanding how neurons are wired to form circuits in the eye

When we move our head, the whole visual world moves across our eyes. Yet we can still make out a bee buzzing by or a hawk flying overhead, thanks to unique cells in the eye called object motion sensors.

1 Sep 2015

Gene therapy restores visual function in mouse model of LCA1

Mice lacking the protein retGC1, which is deficient in humans suffering Leber congenital amaurosis-1 (LCA1), a disorder that causes severe visual impairment beginning in infancy, received gene therapy to replace retGC1 and showed fully restored visual function that persisted for at least 6 months.

1 Sep 2015

Scientists reveal how a common gene mutation in ALS and FTD disrupts normal cell function

Researchers have determined how the most common gene mutation in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) disrupts normal cell function, providing insight likely to advance efforts to develop targeted therapies for these brain diseases.

27 Aug 2015

Nuclear process in the brain may play critical role in health and disease

Every brain cell has a nucleus, or a central command station. Scientists have shown that the passage of molecules through the nucleus of a star-shaped brain cell, called an astrocyte, may play a critical role in health and disease.

18 Aug 2015

Study suggests potential target for treating familial form of ALS

A healthy motor neuron needs to transport its damaged components from the nerve-muscle connection all the way back to the cell body in the spinal cord. If it cannot, the defective components pile up and the cell becomes sick and dies. Researchers at the NIH's National Institute of Neurological Disorders and Stroke have learned how a mutation in the gene for superoxide dismutase 1 (SOD1), which causes ALS, leads cells to accumulate damaged materials.

13 Aug 2015

Modern living could lead to 'hidden' epidemic of neurological brain disease

Modern living could be responsible for an 'almost epidemic' increase in neurological brain disease, according to new research from Bournemouth University.

6 Aug 2015

New study reveals how infectious proteins spread from gut to the brain

Diagnosis of deadly brain conditions could be helped by new research that shows how infectious proteins that cause the disease spread.

5 Aug 2015

Brain-controlled prosthesis could improve quality of life in people with spinal cord injuries

When we type or perform other precise tasks, our brains and muscles usually work together effortlessly. But when a neurological disease or spinal cord injury severs the connection between the brain and limbs, once-easy motions become difficult or impossible.

3 Aug 2015

Atomic level images reveal how neuropeptide hormone neurotensin may activate its receptors

Many hormones and neurotransmitters work by binding to receptors on a cell's exterior surface. This activates receptors causing them to twist, turn and spark chemical reactions inside cells.