Signaling Pathway News and Research

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An investigation of SARS-CoV-2 infection in diabetic pregnancies

Researchers discuss the basic and clinical science of the potential inter-relationships between diabetes mellitus and COVID-19 in pregnancies.

11 Oct 2021

Deadly subtype of T-cell lymphoma harbors unique mutations

An especially deadly subtype of T-cell lymphoma is distinguished by unique mutations in a specific protein signaling pathway, according to a study published in the journal Blood.

7 Oct 2021

Planar cell polarity pathway found to be responsible for the formation and maintenance of synapses

Within the brain and other parts of the nervous system, synapses are key junctional points in between neurons (the nerve cells) where critical signals are transmitted. More specifically, the "glutamatergic" synapses are the prime "excitatory" synapse junctions that neurons use to activate each other and are known to have broad diversity in size and shape.

7 Oct 2021

Researchers identify mechanism that can lead to deafness in rare Norrie disease

A team of Mass Eye and Ear Scientists led by Albert Edge, PhD, working with research fellow Yushi Hayashi, MD, PhD, has identified the mechanism that can lead to deafness in the rare syndrome, Norrie disease.

5 Oct 2021

The role of ZBP1 in promoting SARS-CoV-2-induced cytokine expression

A new study reported that the ZBP1-induced inflammatory signaling pathway is dependent on ubiquitination and RIPK3’s scaffolding ability, independent of cell death.

5 Oct 2021

Scientists use new technique to study the effects of reactive electrophilic drugs

In 2014, the European Medicines Agency approved the drug Tecfidera for the treatment of relapsing multiple sclerosis, a neurodegenerative disease that affects millions of people worldwide. In multiple sclerosis, inflammation damages the protective myelin insulation around nerves, and the nerves themselves.

30 Sep 2021

Aquaporin 5 induction may be a potential therapy to accelerate resurfacing of corneal defects

Corneal defects often heal themselves, but serious injuries that are left untreated can result in inflammation, infection, ulceration and even blindness.

30 Sep 2021

Third COVID-19 mRNA vaccine booster dose indicated for myelofibrosis patients

A new study discusses the utility of a third booster dose in patients with myelofibrosis.

27 Sep 2021

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

A new review article investigates the clinical and viral characteristics, pathogenesis, as well as human genetic basis associated with COVID-19.

27 Sep 2021

Radiation therapy for ventricular tachycardia may revert heart muscle cells to a younger state

Radiation therapy for ventricular tachycardia — a life-threatening irregular heart rhythm — appears to work by reverting heart muscle cells to a younger state, reducing the irregular rhythms, according to a new study from Washington University School of Medicine in St. Louis.

24 Sep 2021

Research pinpoints new therapeutic opportunity for ovarian clear cell carcinomas

Mutations in the ARID1A gene are present in more than 50% of ovarian clear cell carcinomas (OCCC), for which effective treatments are lacking. Scientists at The Wistar Institute discovered that loss of ARID1A function enhances a cellular stress response pathway that promotes survival of cancer cells, which become sensitive to pharmacological inhibition of this pathway. These findings were published online in Cancer Research, a journal of the American Association for Cancer Research, and point to a new therapeutic opportunity for this type of ovarian cancer for which new solutions are urgently needed.

22 Sep 2021

High-fat diet or genetically induced obesity can lead to loss of hair follicles

It's well known that obesity is linked to the development of numerous diseases in humans. Heart disease, diabetes, and other ailments are extremely common in obese individuals.

21 Sep 2021

R37 MERIT Award supports innovative ovarian cancer research

One of the most impactful advancements during the past decade in treating ovarian cancer is the use of PARP inhibitors (short for poly adenosine diphosphate-ribose polymerase). PARP inhibitors are a type of cancer drug that blocks the PARP enzyme from helping to repair DNA damage in cancer cells.

18 Sep 2021

Novel combination therapy approach to keep leukemia at bay

In chronic leukemias, blocking the overactive kinase JAK2 by a targeted therapy approach is only mitigating the patients' symptoms, but cannot truly change the course of the disease.

16 Sep 2021

A family of proteins may be able to outwit emerging and re-emerging viruses

A family of proteins best known for their role in diminishing HIV infectivity may have the goods to outwit other emerging and re-emerging viruses, scientists have found.

15 Sep 2021

Flu shots and COVID-19 immunity

A new paper finds that the influenza vaccine may influence both the response to and incidence of infection by the SARS-CoV-2.

14 Sep 2021

Immune cells present in tumors from head and neck cancer patients, study reports

A new study from scientists at Emory Vaccine Center and Winship Cancer Institute of Emory University reports that the immune cells that are the major targets of immune checkpoint inhibitors are present in tumors from head and neck cancer patients.

2 Sep 2021

Cultured cartilage cells from the nasal septum could help relieve osteoarthritis in the knee

Cartilage cells from the nasal septum can not only help repair cartilage injuries in the knee – according to researchers from the University of Basel and the University Hospital of Basel, they can also withstand the chronic inflammatory tissue environment in osteoarthritis and even counteract the inflammation.

1 Sep 2021

Researchers convert human stem cells into beta cells using small molecules

The human body can be genetically inclined to attack its own cells, destroying the beta cells in the pancreas that make insulin, which helps convert sugar into energy.

27 Aug 2021

Researchers reveal mechanism underlying most common cause of epileptic seizures

During fetal development, cells should migrate to the outer edge of the brain to form critical connections for information transfer and regulation in the body.

26 Aug 2021