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Cleveland Clinic researchers launch the next step in triple-negative breast cancer vaccine study

Cleveland Clinic researchers have launched the next step in their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.

8 Feb 2023

Increase in resistant Shigella infections among men who have sex with men

Researchers report a rise in Shigella flexneri type 2a infections in men who have sexual intercourse with men in England from September 2021 onward.

7 Feb 2023

Novel type of combination therapy shows potential in acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive form of cancer that originates in the bone marrow, rapidly spreads to the blood and can quickly cause death if not treated promptly.

7 Feb 2023

Study finds high levels of hydrogen peroxide in pancreatic cancer cells

Reactive oxygen species (ROS) are reputed for their involvement in carcinogenesis. Results from a study published in the journal Angewandte Chemie have now shown that the level of one such ROS,

7 Feb 2023

USC researchers identify two promising avenues for developing new ALS treatments

Each year in the U.S., 5,000 patients receive a diagnosis of ALS, an incurable neurodegenerative disease that will likely kill them within two to five years.

7 Feb 2023

Study characterizes mutations in neuraminidase of human-like H5N1 influenza viruses

A study published in PLOS PATHOGENS describes the prevalence and functions of mutations in neuraminidase enzyme of avian H5N1 influenza viruses that are preferentially selected in human H5N1 influenza viruses.

7 Feb 2023

The nature of the immune responses induced by various COVID-19 vaccines developed using different platforms and formulations

Researchers reviewed existing achievements and shortcomings in SARS-CoV-2 vaccine platforms, as well as future-generation vaccine considerations.

7 Feb 2023

Decisions by CVS and Optum panicked thousands of their sickest patients

The fear started when a few patients saw their nurses and dietitians posting job searches on LinkedIn.

7 Feb 2023

Integrated NGS system can deliver accurate, genomics-based diagnoses to accelerate treatment for myeloid neoplasms

Identifying recurrent genetic alterations in myeloid neoplasms has improved diagnosis and expanded targeted treatments available to patients. However, treatment initiation can be delayed by the variable and lengthy turnaround times involved in testing for these alterations.

7 Feb 2023

Newly identified gene signature helps assess cancer risk and optimize treatment

In a paper published in PNAS, Maureen Murphy, Ph.D., Deputy Director of Wistar's Ellen and Ronald Caplan Cancer Center and Ira Brind Professor and Program Leader in the Molecular & Cellular Oncogenesis Program, and team have identified a gene signature that accurately predicts the functioning of P53 variants, important information to assessing cancer risk and optimizing choices for cancer therapeutics.

7 Feb 2023

The role of autonomic dysfunction and postural orthostatic tachycardia syndrome (POTS) in post-acute COVID-19

A new clinical outlook in Nature Reviews Cardiology aimed to analyze the post-acute sequelae of COVID-19 that can pose a threat to patients, their doctors, and the healthcare system.

6 Feb 2023

New research may explain why some patients suffer from long-COVID

A review article published in The Journal of Clinical Investigation deciphers the relationship between rare inborn errors of type I interferon immunity and the development of severe coronavirus disease 2019 (COVID-19) pneumonia.

6 Feb 2023

Researchers identify a new genetic risk factor for age-related macular degeneration

Researchers at Tel Aviv University identified a new genetic risk factor for the complex eye disease AMD (Age-related Macular Degeneration), a leading cause for loss of eyesight at an advanced age.

6 Feb 2023

Cryo-EM provides new insights into the structure of the centromeric region

The genetic material inside cells is organized into structures called chromosomes. The centromere is essential for the correct division of the chromosomes via interaction with spindle microtubules when cells divide and grow.

6 Feb 2023

Recent therapeutic strategies for renal cell carcinoma and the effects of the tumor microenvironment on systemic therapy

Researchers explored the association between the human microbiome and improved renal cell carcinoma outcomes.

6 Feb 2023

Using genetic risk scores for predicting venous thromboembolism

Researchers assess the predictability of venous thromboembolism among adults using genetic risk scores.

5 Feb 2023

Study reveals a vulnerability of macrophages that contributes to chronic inflammatory diseases

Macrophages are cells of the immune system that, in addition to playing an essential role in the early response to microbial infection, also regulate tissue function and inflammation.

3 Feb 2023

Spontaneous coronary artery dissection: The leading cause of pregnancy-associated heart attacks

Despite increased awareness over the past decades, only about half (56%) of women recognize that heart disease is their No. 1 killer. Heart disease is the leading cause of death for women in the United States, accounting for 1 in every 5 female deaths.

3 Feb 2023

Study elucidates the evolutionary conservation and diversification of auditory neural circuits in fruit flies

When it comes to courtship, it is important to ensure that one is interacting with a member of the same species. Animals use multiple sensory systems to confirm that potential mates are indeed suitable, with acoustic communication playing an important role in their decision making.

3 Feb 2023

Deletion of a tumor suppressor gene promotes luminal breast cancer development and resistance to endocrine therapy

A research team from LKS Faculty of Medicine, the University of Hong Kong (HKUMed) discovered that somatic deletion of a tumor suppressor gene AKTIP promotes luminal breast cancer development and resistance to endocrine therapy.

3 Feb 2023

Genetic News and Research

Cleveland Clinic researchers launch the next step in triple-negative breast cancer vaccine study

Increase in resistant Shigella infections among men who have sex with men

Novel type of combination therapy shows potential in acute myeloid leukemia

Study finds high levels of hydrogen peroxide in pancreatic cancer cells

USC researchers identify two promising avenues for developing new ALS treatments

Study characterizes mutations in neuraminidase of human-like H5N1 influenza viruses

The nature of the immune responses induced by various COVID-19 vaccines developed using different platforms and formulations

Decisions by CVS and Optum panicked thousands of their sickest patients

Integrated NGS system can deliver accurate, genomics-based diagnoses to accelerate treatment for myeloid neoplasms

Newly identified gene signature helps assess cancer risk and optimize treatment

The role of autonomic dysfunction and postural orthostatic tachycardia syndrome (POTS) in post-acute COVID-19

New research may explain why some patients suffer from long-COVID

Researchers identify a new genetic risk factor for age-related macular degeneration

Cryo-EM provides new insights into the structure of the centromeric region

Recent therapeutic strategies for renal cell carcinoma and the effects of the tumor microenvironment on systemic therapy

Using genetic risk scores for predicting venous thromboembolism

Study reveals a vulnerability of macrophages that contributes to chronic inflammatory diseases

Spontaneous coronary artery dissection: The leading cause of pregnancy-associated heart attacks

Study elucidates the evolutionary conservation and diversification of auditory neural circuits in fruit flies

Deletion of a tumor suppressor gene promotes luminal breast cancer development and resistance to endocrine therapy

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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