Inflammation News and Research

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Thiol-based mucolytics show potent allosteric inhibition of SARS-CoV-2-ACE2 binding via disulfide reduction

A compelling report, recently released on the bioRxiv* preprint server, describes unexpectedly powerful inhibition of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by thiol-based mucolytic compounds P2119 and P2165, by preventing the virus spike from binding to its host cell receptor, the angiotensin-converting enzyme 2 (ACE2).

5 Jul 2021

Varenicline blocks SARS-CoV-2 infection in cells and animal models

A new paper released on the bioRxiv* preprint server suggests that the nicotinic acetylcholine receptor (nACHR) agonist, varenicline tartrate, has antiviral activity against the virus.

5 Jul 2021

Dietary alteration of certain fatty acids can reduce severity of headaches

Migraine is one of the largest causes of disability in the world. Existing treatments are often not enough to offer full relief for patients.

2 Jul 2021

EULAR Patient Research Partners join in new research project to advance treatment of psoriatic arthritis

Eleven Patient Research Partners (PRPs) from three organizations (EULAR, GRAPPA-EU, and EUROPSO) participate in the new research project HIPPOCRATES, ensuring the patients' perspective is preserved and prioritized in all research activities to maximize the project's impact.

2 Jul 2021

Researchers highlight easily adoptable methods to improve outcomes for patients with gastroesophageal cancer

Two Roswell Park Comprehensive Cancer Center experts were invited to present new insights on treatment of gastroesophageal cancers during the European Society for Medical Oncology World Congress on Gastrointestinal Cancer 2021.

2 Jul 2021

Methylglyoxal detoxification deficits can be involved in the development of schizophrenia

Methylglyoxal (MG) is a highly reactive α-ketoaldehyde formed endogenously as a byproduct of the glycolytic pathway. MG accumulates under conditions of hyperglycemia, impaired glucose metabolism, or oxidative stress.

2 Jul 2021

Research pinpoints a molecular component responsible for modulating flu damage

New experimental data pinpoints a molecular component responsible for modulating the damage the flu can wreck on the lungs.

2 Jul 2021

Salivary markers of oxidative stress during severe COVID-19

An interesting study from researchers at the University of Sharjah, Sharjah, United Arab Emirates, presents evidence that an elevated level of expression of oxidant molecules may be correlated with severe infection and lung injury.

2 Jul 2021

The use of flavonoids as antiviral agents against SARS-CoV-2

Researchers in Iran have undertaken a comprehensive review of flavonoids and their antiviral potential against SARS-CoV-2.

2 Jul 2021

High omega 3 diet associated with reduction of headaches

Eating a diet rich in omega 3 (n-3) fatty acids reduces the frequency of headaches compared with a diet with normal intake of omega 3 and omega 6 (n-6) fatty acids, finds a study published by The BMJ today.

2 Jul 2021

Tell-tale signs of high stroke risk may appear a decade in advance

The tell-tale signs of a person’s susceptibility to a stroke may appear up to 10 years before the event, suggests research published online in the Journal of Neurology Neurosurgery & Psychiatry.

2 Jul 2021

New immunotherapy treatment for cancer patients is more effective and less dangerous

Cell toxicity during immunotherapy is a major limitation to cancer treatment.

2 Jul 2021

High levels of neutrophil extracellular traps found in airways of severely ill Covid-19 patients

When researchers at Lund University in Sweden performed advanced analyses of sputum from the airways of severely ill Covid-19 patients, they found high levels of neutrophil extracellular traps (NETs).

1 Jul 2021

Scientists uncover features of T cells that distinguish fatal COVID-19 from non-fatal cases

While vaccines are doing a remarkable job of slowing the COVID-19 pandemic, infected people can still die from severe illness and new medications to treat them have been slow to arise.

1 Jul 2021

Study explores lectins from plants, fungi, algae and cyanobacteria as pan-coronavirus inhibitors

In a recently published article scientists have provided a detailed description of the utility of mannose-specific lectins in preventing coronavirus infections. They have specifically explained how mannose-specific lectins derived from plants, algae, fungi, and bacteria selectively bind N-glycans present on the surface of viral spike protein and how such interactions can be medically utilized to control coronavirus transmission.

1 Jul 2021

Damage to children’s education — and their health — could last a lifetime

Before the pandemic, 16-year-old Na'ryen Cayou had everything he needed. He had his own room. A partial scholarship to a boys' prep school. A spot playing trombone in the marching band, performing in parades all over New Orleans.

1 Jul 2021

New microchip can measure stress hormones in real time from a drop of blood

A Rutgers-led team of researchers has developed a microchip that can measure stress hormones in real time from a drop of blood.

1 Jul 2021

New software tool can help identify gene regulators more efficiently

A team of scientists at the University of Illinois Chicago has developed a software tool that can help researchers more efficiently identify the regulators of genes. The system leverages a machine learning algorithm to predict which transcription factors are most likely to be active in individual cells.

1 Jul 2021

Researchers identify proteins that contribute to the pathogenicity of COVID-19 virus

Researchers at Texas Biomedical Research Institute (Texas Biomed) have narrowed down the proteins enabling SARS-CoV-2 to cause disease.

1 Jul 2021

New experimental model simulates the blood-brain barrier

Using an experimental model to simulate the blood-brain barrier, scientists in Sweden reported in unprecedented detail how antioxidants protect the brain from inflammation caused by neurodegenerative diseases such as Alzheimer's and Parkinson's.

1 Jul 2021

Inflammation News and Research

Thiol-based mucolytics show potent allosteric inhibition of SARS-CoV-2-ACE2 binding via disulfide reduction

Varenicline blocks SARS-CoV-2 infection in cells and animal models

Dietary alteration of certain fatty acids can reduce severity of headaches

EULAR Patient Research Partners join in new research project to advance treatment of psoriatic arthritis

Researchers highlight easily adoptable methods to improve outcomes for patients with gastroesophageal cancer

Methylglyoxal detoxification deficits can be involved in the development of schizophrenia

Research pinpoints a molecular component responsible for modulating flu damage

Salivary markers of oxidative stress during severe COVID-19

The use of flavonoids as antiviral agents against SARS-CoV-2

High omega 3 diet associated with reduction of headaches

Tell-tale signs of high stroke risk may appear a decade in advance

New immunotherapy treatment for cancer patients is more effective and less dangerous

High levels of neutrophil extracellular traps found in airways of severely ill Covid-19 patients

Scientists uncover features of T cells that distinguish fatal COVID-19 from non-fatal cases

Study explores lectins from plants, fungi, algae and cyanobacteria as pan-coronavirus inhibitors

Damage to children’s education — and their health — could last a lifetime

New microchip can measure stress hormones in real time from a drop of blood

New software tool can help identify gene regulators more efficiently

Researchers identify proteins that contribute to the pathogenicity of COVID-19 virus

New experimental model simulates the blood-brain barrier

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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