Protein C News and Research

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Extraordinary plasticity of the glucocorticoid receptor revealed

Glucocorticoids —such as cortisone— are among the most widely used anti-inflammatory drugs, and are used to treat asthma, psoriasis, organ transplantation and even COVID-19.

15 Dec 2022

Tiny messenger can be promising candidate for treatment of diseases associated with muscular atrophy

WNT messenger proteins are crucial for a variety of cellular functions. A specific WNT messenger can increase muscle mass and improve regeneration in skeletal muscle.

14 Dec 2022

Common kidney disease could be treated with existing medicines, new study shows

A serious condition that can cause the kidneys to suddenly stop working could be treated with existing medicines, a new study shows.

14 Dec 2022

Research reveals that a viral toxin may contribute to the severity of COVID-19

Researchers determine whether the SARS-CoV-2 spike protein influences endothelial and epithelial barrier dysfunction and vascular leakage.

14 Dec 2022

Study finds a novel therapeutic target for prevention and treatment of gout

Many Americans think of gout as a disease from a bygone era, akin to rickets or scurvy. The condition commonly afflicted the rich and royal, including American historical figures such as Benjamin Franklin and Thomas Jefferson.

14 Dec 2022

The implications of pulmonary tissue-resident memory T lymphocytes in COVID-19 and other respiratory diseases

Researchers elucidated the mechanisms of long-term T lymphocyte lodgement in tissues other than lymphoid tissues and the reasons for the transient residency of specific subsets of tissue-resident memory T (TRM) lymphocytes.

14 Dec 2022

What are the risk factors associated with symptomatic SARS-CoV-2 and rhinovirus infection in King County, Washington, from June 2020 to July 2022?

Researchers evaluated the change in symptoms and risk factors associated with positive SARS-CoV-2 tests during the COVID-19 pandemic and compared it to those associated with positive tests of other respiratory viruses among residents of King County, Washington, in the United States.

14 Dec 2022

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Researchers isolated SARS-CoV-2 spike protein-targeted mAbs from convalescent healthcare workers, emphasizing the IGHV1-69 gene, the gene with the greatest structural and allelic variation.

14 Dec 2022

Study indicates need for developing mucosal vaccines to induce potent immune responses at sites where SARS-CoV-2 infection occurs

Researchers measured the antibodies against SARS-CoV-2 from nasal fluid, saliva, and plasma to compare the antibody levels between blood and mucosal fluids.

14 Dec 2022

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Researchers have characterised prostate cancer cell dynamics at a single-cell resolution across the timespan of the disease – from its beginning to the point of androgen independence, where the tumour no longer responds to hormone deprivation therapy.

14 Dec 2022

Bad cholesterol and high blood pressure may be associated with higher risk of cardiovascular disease

High levels of lipoprotein(a), a type of "bad" cholesterol, may be associated with an 18-20% higher risk of cardiovascular disease among people who have hypertension, however, CVD risk was not higher among those without hypertension, according to new research published today in Hypertension, an American Heart Association journal.

13 Dec 2022

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

In a recent study posted to the medRxiv* preprint server, researchers in Australia and Switzerland evaluated the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) in community-based settings of the United States (US).

13 Dec 2022

Obesity and type 2 diabetes impair mRNA COVID vaccine efficacy in mouse model

In a recent study posted to bioRxiv*, researchers in the United States assessed the impact of metabolic diseases on coronavirus disease 2019 (COVID-19) vaccine immunogenicity in a mouse model.

13 Dec 2022

Researchers identify molecular determinants of post-infection long-COVID

In a recent study published in the journal Nature Medicine, researchers presented a transcriptome-wide assessment of blood gene expression changes that occur in acute COVID-19 (coronavirus disease 2019) and are associated with PASC (post-acute sequelae of COVID-19), commonly known as long-COVID.

13 Dec 2022

Globally, COVID-19 mortality biomarkers have varied efficacy

Some of the biomarkers used to predict mortality due to COVID-19 show variable efficacies in different parts of the world;

13 Dec 2022

Mediterranean diet may be a non-intrusive and affordable strategy to overcome infertility

With an emphasis on fruits, vegetables and legumes, the Mediterranean diet has long been applauded for its multiple health benefits. Now, new research shows that it may also help overcome infertility, making it a non-intrusive and affordable strategy for couples trying to conceive.

13 Dec 2022

Virginia Tech researchers receive three grants to study the effects of ultra-processed foods

Scientists in the Virginia Tech College of Agriculture and Life Sciences are investigating the effects of ultra-processed foods on the human body using a variety of research tools.

13 Dec 2022

Study suggests persistent inflammatory response triggered by SARS-CoV-2 may be responsible for observed sequelae in PASC patients

Researchers assessed the association of enhanced migratory or activated CD8+ T cell and reduced avidity reactive cellular response due to post-acute COVID-19 syndrome (PASC).

13 Dec 2022

Clinical efficacy and safety of two injections of a bivalent vaccine as a primary series during a period of Omicron circulation

Researchers evaluated the bivalent vaccine efficacy against the Omicron VOC.

13 Dec 2022

RNA-targeting CRISPR technology alleviates disease-related phenotypes in Huntington’s models

Huntington's disease (HD) is a neurological disorder that causes progressive loss of movement, coordination and cognitive function.

12 Dec 2022

Protein C News and Research

Extraordinary plasticity of the glucocorticoid receptor revealed

Tiny messenger can be promising candidate for treatment of diseases associated with muscular atrophy

Common kidney disease could be treated with existing medicines, new study shows

Research reveals that a viral toxin may contribute to the severity of COVID-19

Study finds a novel therapeutic target for prevention and treatment of gout

The implications of pulmonary tissue-resident memory T lymphocytes in COVID-19 and other respiratory diseases

What are the risk factors associated with symptomatic SARS-CoV-2 and rhinovirus infection in King County, Washington, from June 2020 to July 2022?

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Study indicates need for developing mucosal vaccines to induce potent immune responses at sites where SARS-CoV-2 infection occurs

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Bad cholesterol and high blood pressure may be associated with higher risk of cardiovascular disease

Characterization of immune evasion and cell entry for new variants: BQ.1.1, XBB.1, and BR.2.1

Obesity and type 2 diabetes impair mRNA COVID vaccine efficacy in mouse model

Researchers identify molecular determinants of post-infection long-COVID

Globally, COVID-19 mortality biomarkers have varied efficacy

Mediterranean diet may be a non-intrusive and affordable strategy to overcome infertility

Virginia Tech researchers receive three grants to study the effects of ultra-processed foods

Study suggests persistent inflammatory response triggered by SARS-CoV-2 may be responsible for observed sequelae in PASC patients

Clinical efficacy and safety of two injections of a bivalent vaccine as a primary series during a period of Omicron circulation

RNA-targeting CRISPR technology alleviates disease-related phenotypes in Huntington’s models

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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