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Penn researchers pinpoint some effective HIV drugs in causing neuronal damage

Antiretroviral drugs have been life-changing therapies for HIV patients, but they can have significant side effects.

16 Dec 2016

Study suggests revolutionary way to make cancer cells more susceptible to existing chemotherapies

The same signal that drives aggressive growth in a deadly cancer cell type also triggers coping mechanisms that make it "notoriously" hard to kill, according to a study published online December 15 in Cell. When stressed, this cell type - far more than most cancer cells - encases its genetic messages in protein globs called "stress granules" that lessen the effect of chemotherapies.

16 Dec 2016

Researchers develop promising therapeutic antibodies against tumor-promoting MMPs

Researchers at the University of California, Riverside have camels and llamas to thank for their development of a new cancer treatment that is highly selective in blocking the action of faulty matrix metalloproteinases (MMPs).

16 Dec 2016

Researchers identify attractive drug candidate to target glioma tumors

In a paper published today in Cancer Research, researchers: 1) identify a biomarker enzyme associated with aggressive glioma brain tumors, 2) reveal the regulatory mechanism for that enzyme, and 3) demonstrate potent efficacy, using a mouse model of glioma, for a small molecule inhibitor they have developed.

16 Dec 2016

Scientists discover new class of host molecules to transport steroids in the body

Synthetic hosts are to transport medical substances and hormones into the body and to release them at specific points.

16 Dec 2016

Researchers correct motor symptoms linked to Parkinson's disease in mice

A research group led by University of Helsinki Docent Timo Myöhänen has succeeded in correcting the motor symptoms associated with Parkinson's disease in mice.

15 Dec 2016

Common bacterium that causes gum infections may trigger rheumatoid arthritis

Investigators at Johns Hopkins report they have new evidence that a bacterium known to cause chronic inflammatory gum infections also triggers the inflammatory "autoimmune" response characteristic of chronic, joint-destroying rheumatoid arthritis (RA).

15 Dec 2016

BBI Solutions announces launch of Porcine Liver Esterase enzyme for Urinalysis

BBI Solutions today announced the launch of Porcine Liver Esterase (PLE), a new enzyme for Urinalysis, which is available to sample now.

14 Dec 2016

New study may shed light on diseases associated with mutations in aminoacyl tRNA synthetases

New research led by scientists at The Scripps Research Institute reveals that a human enzyme has changed little from its days as a bacterial enzyme. In fact, the enzyme appears to be unique in its ability to change its shape—and its job in cells—without overhauling its basic architecture.

14 Dec 2016

Scientists explain concept of combining NO gas therapy with starvation of tumor cells for nanomedical treatment

Biocompatible nanocapsules, loaded with an amino acid and equipped with an enzyme now combine two anti-tumor strategies into a synergistic treatment concept. Researchers hope this increases effectiveness and decreases side effects.

14 Dec 2016

Research into common congenital brain defect identifies molecular basis

Scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) have discovered a molecular cause of hydrocephalus, a common, potentially life-threatening birth defect in which the head is enlarged due to excess fluid surrounding the brain.

14 Dec 2016

Researchers discover new pathway that opens door to treat non-alcoholic fatty liver disease

Researchers from the University of South Carolina, Duke University, University of Alabama at Birmingham, and Metabolon Inc. Research Triangle Park have discovered a new pathway in the liver that opens the door to treat non-alcoholic fatty liver disease, a condition that affects up to 25 percent of the population and may lead to cirrhosis and eventually liver cancer or failure, and likely other liver diseases.

9 Dec 2016

Researchers uncover first ‘off-switches’ for better control of CRISPR/Cas9 gene editing

CRISPR/Cas9 genome editing is quickly revolutionizing biomedical research, but the new technology is not yet exact. The technique can inadvertently make excessive or unwanted changes in the genome and create off-target mutations, limiting safety and efficacy in therapeutic applications.

9 Dec 2016

Enzyme News and Research

Penn researchers pinpoint some effective HIV drugs in causing neuronal damage

Study suggests revolutionary way to make cancer cells more susceptible to existing chemotherapies

Researchers develop promising therapeutic antibodies against tumor-promoting MMPs

Researchers identify attractive drug candidate to target glioma tumors

Scientists discover new class of host molecules to transport steroids in the body

Researchers correct motor symptoms linked to Parkinson's disease in mice

Common bacterium that causes gum infections may trigger rheumatoid arthritis

BBI Solutions announces launch of Porcine Liver Esterase enzyme for Urinalysis

New study may shed light on diseases associated with mutations in aminoacyl tRNA synthetases

Scientists explain concept of combining NO gas therapy with starvation of tumor cells for nanomedical treatment

Research into common congenital brain defect identifies molecular basis

Researchers discover new pathway that opens door to treat non-alcoholic fatty liver disease

Researchers uncover first ‘off-switches’ for better control of CRISPR/Cas9 gene editing

Researchers identify protein that degrades and inhibits infectious biofilms

Research reveals opposing role for SNAP23 protein in endocrine and exocrine pancreas

Researchers discover biological pathway that plays vital role in tumor development

Scientists uncover new class of compounds that could help target cancer cells

TSRI scientists identify potential therapeutic target for age- or Alzheimer's disease-related memory deficits

Scientists find new approach to develop cheaper calorie-free sweeteners

Disturbances in the body’s carbon monoxide metabolism linked to circadian disruption

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

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Advancing degrader and proximity-based drug development

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Expanding access to NMR with the Fourier 80 Duo