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Researchers unlock new insights into hard-to-treat neuroendocrine tumors

Researchers at Boston Medical Center and Dana-Farber Cancer Institute conducted one of the first-ever analyses of neuroendocrine tumors (NETs) at single cell resolution, unlocking new insights into this rare and often hard-to-treat cancer.

28 Sep 2023

Neoadjuvant immunotherapy shows promise in multiple cancer types

Treating cancer with immunotherapies known as an immune checkpoint blockade (ICB) prior to surgery (so-called neoadjuvant immunotherapy) has been a rapidly growing area of research, but the scientific community is just scratching the surface of what is possible, according to a review article co-authored by several current and former investigators from the Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Kimmel Cancer Center.

28 Sep 2023

Researchers describe the origin and fate of liver myofibroblasts

Hepatic fibrosis occurs when scar tissue replaces damaged cells in the liver. Over time, accumulating scarring distorts the liver, interferes with its blood supply and may progressively lead to worsening consequences, from cirrhosis to liver failure to liver cancer.

28 Sep 2023

Newly identified stem cell variants drive inflammation in cystic fibrosis patients

Two nationally recognized experts in cloning and stem cell science from the University of Houston, Wa Xian and Frank McKeon, are reporting that five lung stem cell variants dominate the lungs of patients with advanced cystic fibrosis (CF), and that these variants drive key aspects of CF pathology including inflammation, fibrosis and mucin secretion.

28 Sep 2023

Vaxzevria vaccine boosts mucosal immunity in COVID-19 recovered

Study highlights the ability of the Vaxzevria vaccine in inducing robust mucosal antibody responses, especially in COVID-19-recovered individuals, showcasing a notable defense against various SARS-CoV-2 variants. However, it emphasizes the need for booster doses to enhance anti-SARS-CoV-2 mucosal immunity, especially in infection-naïve individuals, to broaden protection against emerging viral variants.

28 Sep 2023

Insights and new directions in basic, clinical research into neurodegenerative diseases

A special supplement to the Journal of Alzheimer's Disease, published by IOS Press, presents insights and new directions in both basic and clinical research into neurodegenerative diseases.

28 Sep 2023

New approach could improve immune checkpoint inhibitor response in MTAP-deficient tumors

Loss of the "housekeeping" gene methylthioadenosine phosphorylase, or MTAP, is a common event in cancer.

28 Sep 2023

SARS-CoV-2 virus can trigger dangerous immune response in artery-clogging plaques

In some patients, infection with the pandemic virus SARS-CoV-2 can trigger a dangerous immune response in hardened fatty deposits (plaques) lining the heart's largest blood vessels, a new study shows.

28 Sep 2023

Bioengineered human stomach micro-physiological system reveals unseen defense mechanisms

A groundbreaking development in biomedical engineering has led to the creation of a human stomach micro-physiological system (hsMPS), representing a significant leap forward in understanding and treating various gastrointestinal diseases, including stomach cancer.

28 Sep 2023

SARS-CoV-2 infects coronary vessels, inducing plaque inflammation

SARS-CoV-2, the virus that causes COVID-19, can directly infect the arteries of the heart and cause the fatty plaque inside arteries to become highly inflamed, increasing the risk of heart attack and stroke, according to a study funded by the National Institutes of Health.

28 Sep 2023

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer’s disease progression

Alzheimer's disease affects more than 6 million people in the United States, and there are very few FDA-approved treatments that can slow the progression of the disease.

28 Sep 2023

Natural antibiotic thiostrepton reveals new hope for inflammatory bowel disease treatment

Researchers explored the therapeutic impact of Thiostrepton on experimental colitis by examining its effects on colon inflammation and determining its targets through various biochemical approaches.

28 Sep 2023

Study uncovers previously unknown compensatory mechanism in liver disease

A team of researchers has uncovered a previously unknown compensatory mechanism found in liver disease.

28 Sep 2023

Examining the cardiac pathology in fatal cases of yellow fever

The characteristics of yellow fever (YF)-related myocardial damage.

28 Sep 2023

Non-alcoholic fatty liver disease linked to higher risk of blood clots in healthy adults

Recent study in Scientific Reports finds a link between nonalcoholic fatty liver disease (NAFLD) and a higher risk of venous thromboembolism (VTE) among healthy Korean adults. The research suggests that NAFLD may contribute to a hypercoagulable state, increasing the risk of VTE.

27 Sep 2023

Yeast in the gut linked to Crohn's disease inflammation, opening new doors for treatment

New study in Nature Medicine links yeast cells in the gastrointestinal tract to abnormal immune responses causing inflammation in Crohn's disease patients. The research suggests that these yeast-reactive T-cells could be a potential therapeutic target, offering new avenues for treatment.

27 Sep 2023

Self‐administration of investigational intranasal spray may be a new option to treat rapid heartbeat

A fast-acting medication delivered as a nasal spray may someday allow patients with intermittent rapid heartbeats to treat it themselves as soon as they develop symptoms, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

27 Sep 2023

Researchers develop new way to boost immune cells' ability to fight TB

Tuberculosis is old - ancient even. The infectious bacterial disease that plagued Old Testament Israelites and took down pharaohs was eventually stunted by vaccinations, antibiotics, and public health measures like isolation, but it hasn't been cured yet.

27 Sep 2023

HMS researcher to lead $104 million effort to study bacteria and antibiotic resistance

Harvard Medical School researcher Johan Paulsson will lead a multi-institutional $104 million effort to study bacteria and antibiotic resistance, the U.S. Department of Health and Human Services announced today.

27 Sep 2023

Study details the key role played by neutrophils in ensuring survival of brain cancers

A Ludwig Cancer Research study has for the first time exhaustively analyzed immune cells known as neutrophils that reside in brain tumors, including gliomas, which develop in the brain itself, and cancers that spread there from the lung, breast and skin.

27 Sep 2023

B Cell News and Research

Researchers unlock new insights into hard-to-treat neuroendocrine tumors

Neoadjuvant immunotherapy shows promise in multiple cancer types

Researchers describe the origin and fate of liver myofibroblasts

Newly identified stem cell variants drive inflammation in cystic fibrosis patients

Vaxzevria vaccine boosts mucosal immunity in COVID-19 recovered

Insights and new directions in basic, clinical research into neurodegenerative diseases

New approach could improve immune checkpoint inhibitor response in MTAP-deficient tumors

SARS-CoV-2 virus can trigger dangerous immune response in artery-clogging plaques

Bioengineered human stomach micro-physiological system reveals unseen defense mechanisms

SARS-CoV-2 infects coronary vessels, inducing plaque inflammation

Study reveals a complex interplay of genetic and epigenetic changes in Alzheimer’s disease progression

Natural antibiotic thiostrepton reveals new hope for inflammatory bowel disease treatment

Study uncovers previously unknown compensatory mechanism in liver disease

Examining the cardiac pathology in fatal cases of yellow fever

Non-alcoholic fatty liver disease linked to higher risk of blood clots in healthy adults

Yeast in the gut linked to Crohn's disease inflammation, opening new doors for treatment

Self‐administration of investigational intranasal spray may be a new option to treat rapid heartbeat

Researchers develop new way to boost immune cells' ability to fight TB

HMS researcher to lead $104 million effort to study bacteria and antibiotic resistance

Study details the key role played by neutrophils in ensuring survival of brain cancers

Using single B cell screening to boost antibody discovery eBook

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

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