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Study identifies risk factors for delirium among hospitalized patients in Zambia

Severity of illness, history of stroke, and being divorced or widowed were independently predictive of delirium in hospitalized patients in Zambia, according to a study published in PLOS ONE.

22 Apr 2021

New Phase 3 trial of therapeutics begins enrolling severely ill hospitalized COVID-19 patients

A new Phase 3 trial to test the safety and efficacy of therapeutics for COVID-19 has begun enrolling patients hospitalized with life-threatening cases of COVID-19, including those with acute respiratory failure.

22 Apr 2021

Researchers aim to better understand clinical features associated with COVID-19 mortality

To better understand the COVID-19 clinical feaures associated with mortality, an interdisciplinary team of researchers has investigated important factors and their influence on a patient’s death.

22 Apr 2021

Some COX inhibitors/NSAIDs increase COVID-19 severity

A startling new preprint research paper posted to the medRxiv server warns against the use of commonly used non-steroidal anti-inflammatory drugs (NSAIDs) belonging to the category of cyclooxygenase inhibitors (COX inhibitors) in patients with coronavirus disease 2019 (COVID-19).

22 Apr 2021

B.1.1.7 variant 45% more infectious than wild-type SARS-CoV-2, but can be effectively contained by BNT162b2 vaccine

The SARS-CoV-2 B.1.1.7 variant, also called the UK variant, was identified in London as well as in Southeast and East of England in December 2020. Since its emergence, the UK variant has undergone several mutations that have been said to have altered its infectivity and transmissibility in the community. The B.1.1.7 variant is defined by 17 mutations, several of which are located in the SARS-CoV-2 spike protein that mediates viral attachment and entry into human cells.

21 Apr 2021

Algorithm accurately identifies pulmonary arterial hypertension in patients with scleroderma

Screening for a sometimes fatal condition among patients with a rare autoimmune disease could soon - thanks to a computer algorithm - become even more accurate.

21 Apr 2021

Can sniffer dogs be trained to detect SARS-CoV-2 infection?

A new study in PLOS ONE discusses the novel use of dogs to sniff out the virus in patient samples as a potential additional diagnostic route to ease the situation.

21 Apr 2021

Researchers examine antiviral responses in children infected with COVID-19 in South Brazil

New research has been published that focuses on the characterization of innate and adaptive immune responses in adult patients with different degrees of severity and also in pediatric patients with mild symptoms of COVID-19. In this study, researchers have developed an immune profile in children to understand the difference in COVID-19 infection in children and adults.

21 Apr 2021

Study evaluates stem cells' ability to prevent major cause of death in preterm infants

A phase 2 clinical trial whose results were released today in STEM CELLS Translational Medicine might point to a way to overcome bronchopulmonary dysplasia (BPD), a major cause of death in preterm infants.

20 Apr 2021

Study identifies higher mortality risk for women with back pain

New research from Boston Medical Center identifies elevated mortality risk for women with back pain when compared to women without back pain. Back pain was not associated with mortality among men indicating long-term consequences of back pain may differ by sex.

20 Apr 2021

Systematic review: Exposure to endocrine-disruptors could elevate breast cancer risk

Exposure to certain endocrine-disrupting chemicals could elevate the risk of breast cancer, according to a new comprehensive systematic review of epidemiological research.

20 Apr 2021

Study provides the first extensive genetic and phenotype landscape of peripartum cardiomyopathy

Researchers at Penn Medicine have identified more genetic mutations that strongly predispose younger, otherwise healthy women to peripartum cardiomyopathy (PPCM), a rare condition characterized by weakness of the heart muscle that begins sometime during the final month of pregnancy through five months after delivery.

20 Apr 2021

Study shows link between disturbed sleep and increased risk of cardiovascular death in women

For the first time, a study has shown a clear link between the frequency and duration of unconscious wakefulness during night-time sleep and an increased risk of dying from diseases of the heart and blood vessels, and death from any cause, particularly in women.

20 Apr 2021

Immune tolerance in hemophilia can be modulated by B cell activating factor

A group of scientists have just made a key discovery that could prevent and eradicate immune responses that lead to treatment failure in about one-third of people with severe hemophilia A.

20 Apr 2021

Yale scientists uncover common mechanism that promotes autoimmune diseases and blood cancers

In a study by Yale Cancer Center, researchers report on the discovery of a common mechanism that promotes both autoimmune diseases and blood cancers, including the blood diseases Acute Lymphoblastic Leukemia (ALL), Chronic Lymphocytic Leukemia (CLL) and Mantle Cell Lymphoma (MCL).

19 Apr 2021

Study uncovers role for STING in regulating tumor response to DNA-damaging treatments

In a study by Yale Cancer Center, researchers report on the discovery of a new role for STimulator of INterferon Genes or STING.

19 Apr 2021

COVID-19 patients who are overweight or obese may develop a more severe infection

COVID-19 patients who are overweight or obese are more likely to develop a more severe infection than patients of healthy weight, and they require oxygen and invasive mechanical ventilation more often. There is no increased risk of death .

19 Apr 2021

Chemical biomarker could be used to better manage treatments for COVID-19

Varying severity of COVID-19 symptoms in patients is reflected by levels of a chemical biomarker in their body which scientists say could be used to better manage treatments and other interventions, including vaccinations.

19 Apr 2021

Researchers test whether feces transplantation can help patients with cirrhosis of the liver

Researchers from Aarhus University and Aarhus University Hospital replace sick intestinal bacteria with intestinal bacteria from healthy donors in a treatment intended to help patients with cirrhosis of the liver. The Novo Nordisk Foundation supports the project with just over DKK 13 million.

19 Apr 2021

Plant-derived compound isorhamnetin may have antiviral potential against SARS-CoV-2

The lack of new or repurposed drugs to treat patients with severe or critical COVID-19 has been one of the biggest hurdles to reducing mortality rates in the ongoing pandemic caused by SARS-CoV-2. A new study describes the potential for the use of the plant molecule isorhamnetin in the management of this virus.

19 Apr 2021

Mortality News and Research

Study identifies risk factors for delirium among hospitalized patients in Zambia

New Phase 3 trial of therapeutics begins enrolling severely ill hospitalized COVID-19 patients

Researchers aim to better understand clinical features associated with COVID-19 mortality

Some COX inhibitors/NSAIDs increase COVID-19 severity

B.1.1.7 variant 45% more infectious than wild-type SARS-CoV-2, but can be effectively contained by BNT162b2 vaccine

Algorithm accurately identifies pulmonary arterial hypertension in patients with scleroderma

Can sniffer dogs be trained to detect SARS-CoV-2 infection?

Researchers examine antiviral responses in children infected with COVID-19 in South Brazil

Study evaluates stem cells' ability to prevent major cause of death in preterm infants

Study identifies higher mortality risk for women with back pain

Systematic review: Exposure to endocrine-disruptors could elevate breast cancer risk

Study provides the first extensive genetic and phenotype landscape of peripartum cardiomyopathy

Study shows link between disturbed sleep and increased risk of cardiovascular death in women

Immune tolerance in hemophilia can be modulated by B cell activating factor

Yale scientists uncover common mechanism that promotes autoimmune diseases and blood cancers

Study uncovers role for STING in regulating tumor response to DNA-damaging treatments

COVID-19 patients who are overweight or obese may develop a more severe infection

Chemical biomarker could be used to better manage treatments for COVID-19

Researchers test whether feces transplantation can help patients with cirrhosis of the liver

Plant-derived compound isorhamnetin may have antiviral potential against SARS-CoV-2

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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