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Novel approach to cancer risk assessment maximizes public health benefits

Edward Calabrese, the University of Massachusetts Amherst environmental toxicologist who has been an outspoken critic of the current linear no-threshold (LNT) approach to risk assessment for radiation and toxic chemicals, now proposes a new approach integrating LNT with hormetic dose-response models.

23 Mar 2016

Parasitic flatworm rejuvenates its skin to survive in human bloodstream

A parasitic flatworm that infects hundreds of millions of people in the developing world is able to survive in the bloodstream for decades by constantly renewing its skin - a mechanism that could inform potential new treatments against infection.

23 Mar 2016

UC San Diego Health participates in nationwide clinical study on hemophilia B gene therapy

The Hemophilia and Thrombosis Treatment Center at UC San Diego Health has joined a nationwide clinical trial testing a potential gene therapy that may one day provide a better and long-lasting treatment for people with hemophilia B.

23 Mar 2016

YAP protein plays vital role in development of human neural crest

The Hippo/YAP signalling pathway plays a crucial role when the cells of the neural crest - a structure that generates cell types such as bones and nerve tissue - specialise for a certain function in the human embryo and migrate to their target region within the body.

22 Mar 2016

Moderate drinking not linked to longer life, study shows

Many people believe a glass of wine with dinner will help them live longer and healthier--but the scientific evidence is shaky at best, according to a new research analysis.

22 Mar 2016

Key molecule in breast, lung cancer cells can help prevent spread of cancer

Scientists have revealed that a key molecule in breast and lung cancer cells can help switch off the cancers' ability to spread around the body.

22 Mar 2016

Mycophenolate mofetil drug seems safe, effective in treating autoimmune hepatitis

New research indicates that mycophenolate mofetil, a drug that is usually used to prevent rejection after kidney, heart or liver transplant, seems safe and effective in treating autoimmune hepatitis (AIH), a serious chronic liver disease that mainly affects women.

22 Mar 2016

Doctors now have better tool to assess individual kidney function

Doctors now have a much-improved tool to assess individual kidney function, thanks to the work of an international team led by University of Saskatchewan medical imaging specialists Drs. Carl and Michal Wesolowski.

21 Mar 2016

Sodium MRI could provide more detailed picture of tissue health and disease

MRI experts at The University of Nottingham win £1m grant to adapt scanning techniques to pick up sodium in the body. The research could lead to much more detailed MRI scans in the future with significant improvements to the diagnosis and treatment of many diseases.

18 Mar 2016

Clinical study finds no added benefit of using four TB drugs to save people with advanced HIV/AIDS

In a report on the so-called REMEMBER (Reducing Early Mortality and Early Morbidity by Empiric Tuberculosis Treatment) study -- a 10-nation, randomized clinical trial of adult outpatients -- investigators concluded that there was no added benefit of using four drugs for TB over just using one drug, isoniazid, to save lives in people with advanced HIV/AIDS.

18 Mar 2016

Treatment guidelines need to be changed for rare, genetic form of diabetes, study suggests

Patients with a rare, genetic form of diabetes often are misdiagnosed as having type 2 diabetes because the two share symptoms.

18 Mar 2016

WSU researcher explores new drugs to treat neurological disorders linked to autophagic dysfunction

Repairing the brain's "house-cleaning function," which could help people with Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS) and 100 other diseases, is the focus of recently funded research at Washington State University.

17 Mar 2016

MUSC surgeon awarded $3.8 million grant to evaluate transplant drug

Seldom can one say $3.8 million is just the tip of the iceberg, but a newly awarded grant from Gilead Sciences, Inc. is just that. MUSC transplant surgeon Kenneth Chavin, M.D., Ph.D., says the true value of the multi-center drug trial is closer to $26 million, including $22 million in free drugs provided by the pharmaceutical company.

17 Mar 2016

Study: Statin drugs can reduce time to clear tuberculosis infection in mice

In a study using mice, the Johns Hopkins University School of Medicine infectious disease experts have added to evidence that statin drugs — known primarily for their cholesterol-lowering effects — can significantly reduce the time it takes to clear tuberculosis infection.

17 Mar 2016

Kanazawa University researchers identify molecular mechanism that links liver disease and obesity

Kanazawa University researchers find similarities in the impeded signalling between central insulin activity and glucose production in the liver for both obese mice and mice that have had the vagus nerve removed.

16 Mar 2016

Global research links genes to five common, hard-to-treat inflammatory diseases

A global study involving 50 different research centres has found hundreds of genes which cause five common, hard-to-treat and debilitating inflammatory diseases, paving the way to new treatments for these conditions

16 Mar 2016

UCSF study marks important step toward finding cure for Ebola

In experiments carried out partly at the Department of Energy's SLAC National Accelerator Laboratory, scientists have determined in atomic detail how a potential drug molecule fits into and blocks a channel in cell membranes that Ebola and related "filoviruses" need to infect victims' cells.

15 Mar 2016

New drug could transform treatment of metastatic triple negative breast cancer

A team of investigators from Houston Methodist Research Institute may have transformed the treatment of metastatic triple negative breast cancer by creating the first drug to successfully eliminate lung metastases in mice.

15 Mar 2016

Liposomes can be potential candidates for drug delivery to constricted coronary arteries

Liposomes are currently used as drug delivery vehicles but recognized by the immune system. Scientists from the universities of Basel and Fribourg have shown that special artificial liposomes do not elicit any reaction in human and porcine sera as well as pigs.

14 Mar 2016

Researchers exploring ways to prevent radiation-induced cancer risk in astronauts

NASA limits an astronaut's radiation exposures to doses that keep their added risk of fatal cancer below 3 percent. Unfortunately, that ceiling restricts the time an astronaut may spend in space, which in turn restricts the ability to perform longer missions, say a mission to Mars.

14 Mar 2016

Liver News and Research

Novel approach to cancer risk assessment maximizes public health benefits

Parasitic flatworm rejuvenates its skin to survive in human bloodstream

UC San Diego Health participates in nationwide clinical study on hemophilia B gene therapy

YAP protein plays vital role in development of human neural crest

Moderate drinking not linked to longer life, study shows

Key molecule in breast, lung cancer cells can help prevent spread of cancer

Mycophenolate mofetil drug seems safe, effective in treating autoimmune hepatitis

Doctors now have better tool to assess individual kidney function

Sodium MRI could provide more detailed picture of tissue health and disease

Clinical study finds no added benefit of using four TB drugs to save people with advanced HIV/AIDS

Treatment guidelines need to be changed for rare, genetic form of diabetes, study suggests

WSU researcher explores new drugs to treat neurological disorders linked to autophagic dysfunction

MUSC surgeon awarded $3.8 million grant to evaluate transplant drug

Study: Statin drugs can reduce time to clear tuberculosis infection in mice

Kanazawa University researchers identify molecular mechanism that links liver disease and obesity

Global research links genes to five common, hard-to-treat inflammatory diseases

UCSF study marks important step toward finding cure for Ebola

New drug could transform treatment of metastatic triple negative breast cancer

Liposomes can be potential candidates for drug delivery to constricted coronary arteries

Researchers exploring ways to prevent radiation-induced cancer risk in astronauts

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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