Inflammation News and Research

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Chronic inflammation causes aging of the pituitary gland

Stem cell biologist Hugo Vankelecom (KU Leuven) and his colleagues have discovered that the pituitary gland in mice ages as the result of an age-related form of chronic inflammation. It may be possible to slow down this process or even partially repair it. The researchers have published their findings in PNAS.

15 Jun 2021

Prenatal exposure to air pollutants may increase infants' obesity risk

Women exposed to higher levels of air pollution during pregnancy have babies who grow unusually fast in the first months after birth, putting on excess fat that puts them at risk of obesity and related diseases later in life, new CU Boulder research shows.

15 Jun 2021

Potent antibodies against SARS-CoV-2 can be produced without T follicular helper cells, suggests study

It has been uncertain whether antibodies produced via this non-canonical pathway are protective against SARS-CoV-2. In a new study, recently released as a preprint on the bioRxiv*server, the neutralization potency of these antibodies is compared with those traditionally produced in germinal center-based antiviral responses.

15 Jun 2021

CDC reports rare cases of heart inflammation in young men after mRNA COVID-19 vaccination

Vaccination efforts have rolled out in most countries starting in the last quarter of 2020 with more than 2.37 billion vaccines administered worldwide so far. However, reports of cardiac inflammation (myocarditis and pericarditis) occurring after the mRNA COVID-19 vaccination (Pfizer-BioNTech and Moderna) have increased in the United States since April 2021.

15 Jun 2021

UIC discovery may lead to new treatments for alcohol use disorder and depression

A discovery from researchers at the University of Illinois Chicago may lead to new treatments for individuals who suffer from alcohol use disorder and depression.

14 Jun 2021

Virginia Tech researcher receives $2.2 million to advance study on small 'fat burning' molecules

The liver is the most resilient organ in the human body. It can remove toxins from the bloodstream, recycle red blood cells, maintain sugar levels, and it can even regenerate itself. But, when a large amount of fat builds up in the liver, it becomes too inflamed to perform its crucial duties.

14 Jun 2021

Plant-based diet appears to offer protection against hypertension and preeclampsia

A plant-based diet appears to afford significant protection to rats bred to become hypertensive on a high-salt diet, scientists report. When the rats become pregnant, the whole grain diet also protects the mothers and their offspring from deadly preeclampsia.

14 Jun 2021

Robust immunity against SARS-CoV-2 with Pfizer vaccine is mediated by memory B cells

A reassuring study, released as a preprint on the medRxiv* server, from a multi-institutional team of researchers in Italy suggests that with the Pfizer-BioNTech BNT162b2 vaccine, post-vaccination immunity against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is both robust and durable.

14 Jun 2021

Forkhead box O's potential therapeutic use in the treatment of COVID-19

In a recent study, Indian researchers from the Department of Biochemistry, University of Delhi, reviewed a possible vital coalition of FoxOs - the Forkhead Box O subfamily of protein transcription factors, with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the etiological agent of COVID-19 (coronavirus disease).

13 Jun 2021

An analysis links COVID-19 to brain microvascular injury and inflammation

The ongoing COVID-19 pandemic is caused by the severe acute respiratory syndrome-2 (SARS-CoV-2), an RNA virus that belongs to the family Coronaviridae. According to research, coronavirus disease 2019 (COVID-19) patients often suffer from neurological disorders like strokes, lost taste or smell, memory loss, confusion, and delirium.

13 Jun 2021

DFG funds four collaborative research centers at Goethe University

Researching intricate geometric and arithmetic objects is the goal of the new Collaborative Research Centre Transregio 326 (TRR 326), coordinated by Goethe University.

11 Jun 2021

Study identifies mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia

A new Cleveland Clinic-led study has identified mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia.

11 Jun 2021

Statins associated with reduced COVID-19 mortality and decreased need for ventilator support

Statins are medications widely used in the management of cardiovascular diseases and metabolic syndrome. Statins help lower serum lipids by blocking HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase), the rate-limiting enzyme of cholesterol biosynthesis.

11 Jun 2021

Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Metformin is a widely prescribed blood sugar-lowering drug. It is often used as an early therapy (in combination with diet and lifestyle changes) for type 2 diabetes, which afflicts more than 34 million Americans.

11 Jun 2021

Study: cis P-tau is an early marker of vascular dementia, Alzheimer's disease

Researchers remain perplexed as to what causes dementia and how to treat and reverse the cognitive decline seen in patients.

11 Jun 2021

Cross-sectional study explores differences in biomarkers in fulminant and non-fulminant COVID-19 myocarditis

Researchers from the US recently conducted a study to examine the clinical course and echocardiographic and lab testing across clinically defined fulminant and non-fulminant COVID-19 myocarditis. This study is published on the preprint server, medRxiv.*

11 Jun 2021

CWRU researcher receives $1.2 million to identify biomarkers for improving MS diagnoses

Case Western Reserve University researcher Farren Briggs was awarded $1.2 million over three years from the National Institute of Neurological Disorders and Stroke at the National Institutes of Health to identify biomarkers to improve the diagnoses of multiple sclerosis, including the ability to monitor disease activity and progression.

10 Jun 2021

Local anesthetic procaine inhibits SARS-CoV-2 in vitro

Research has shown that procaine and procaine-hydrochloride can reduce replication of SARS-CoV-2 and influenza A viruses in infected cells and reduce the production of cytokines by the viruses, making them potentially useful for treating COVID-19.

10 Jun 2021

New cell-penetrating peptide may protect against life-threatening microbial inflammation

A cell-penetrating peptide developed by researchers at Vanderbilt University Medical Center can prevent, in an animal model, the often-fatal septic shock that can result from bacterial and viral infections.

9 Jun 2021

DNA on-off switches for SARS-CoV-2 host receptor as potential therapeutic targets

Researchers in the United States and Canada have identified DNA on/off “switches” within the angiotensin-converting enzyme 2 (ACE2) gene that may control the expression of this host cell receptor before, during and after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

9 Jun 2021

Inflammation News and Research

Chronic inflammation causes aging of the pituitary gland

Prenatal exposure to air pollutants may increase infants' obesity risk

Potent antibodies against SARS-CoV-2 can be produced without T follicular helper cells, suggests study

CDC reports rare cases of heart inflammation in young men after mRNA COVID-19 vaccination

UIC discovery may lead to new treatments for alcohol use disorder and depression

Virginia Tech researcher receives $2.2 million to advance study on small 'fat burning' molecules

Plant-based diet appears to offer protection against hypertension and preeclampsia

Robust immunity against SARS-CoV-2 with Pfizer vaccine is mediated by memory B cells

Forkhead box O's potential therapeutic use in the treatment of COVID-19

An analysis links COVID-19 to brain microvascular injury and inflammation

DFG funds four collaborative research centers at Goethe University

Study identifies mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia

Statins associated with reduced COVID-19 mortality and decreased need for ventilator support

Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Study: cis P-tau is an early marker of vascular dementia, Alzheimer's disease

Cross-sectional study explores differences in biomarkers in fulminant and non-fulminant COVID-19 myocarditis

CWRU researcher receives $1.2 million to identify biomarkers for improving MS diagnoses

Local anesthetic procaine inhibits SARS-CoV-2 in vitro

New cell-penetrating peptide may protect against life-threatening microbial inflammation

DNA on-off switches for SARS-CoV-2 host receptor as potential therapeutic targets

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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