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FDA approves Xalkori (crizotinib) to treat patients with ROS-1 positive NSCLC

The U.S. Food and Drug Administration today approved Xalkori (crizotinib) to treat people with advanced (metastatic) non-small cell lung cancer (NSCLC) whose tumors have an ROS-1 gene alteration. Xalkori is the first and only FDA approved treatment for patients with ROS-1 positive NSCLC.

13 Mar 2016

Lots of 'good' cholesterol may be bad

Recent research has identified a genetic mutation that prevents high-density-lipoprotein (HDL) cholesterol from being taken up by cells.

11 Mar 2016

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

microRNAs (miRs) are small endogenous noncoding RNA molecules (20–23 nucleotides) derived from imperfectly paired hairpin RNA structures naturally encoded in the genome that act specifically as triggering molecules to control translational repression or mRNA degradation.

11 Mar 2016

Gallbladder removal surgeries now becomes safer with new imaging procedure

UCLA researchers have discovered an optimal way to image the bile ducts during gallbladder removal surgeries using a tested and safe dye and a real-time near-infrared florescence laparoscopic camera, a finding that will make the procedure much safer for the hundreds of thousands of people who undergo the procedure each year.

11 Mar 2016

Scientists map biological networks of genes to gain new insights on disease mechanisms

Innovative software tools allowed the scientists to construct accurate "maps" of gene networks for about 400 different human cell and tissue types, ranging from immune cells to brain tissues, whereas previous studies were limited to just one or few tissues.

11 Mar 2016

Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

Malfunctioning mitochondria — the power plants in cells — are behind the damage caused by strokes, heart attacks, and neurodegenerative diseases, but little has been known about how to stop these reactors from melting down, destroying cells and tissue. Mitochondria also take up calcium, which regulates energy production.

11 Mar 2016

Springing forward one hour may lead to increased heart attack risk

Many people may groan about losing an hour of sleep March 13, but there may be a more serious reason to be mindful of daylight saving time.

11 Mar 2016

Is the global diet getting sweeter? An interview with Professor Barry Popkin

In the past, caloric sweeteners simply referred to cane sugar or beet sugar. However, over time we've created hundreds of different sugars that are all providing calories of the same amount, about four calories for every gram of the sugar. Some examples include corn syrups and more processed sweeteners like high fructose corn syrup.

10 Mar 2016

Bioengineers introduce CORDA algorithm to find new therapeutic targets for cancer

Rice University bioengineers have introduced a fast computational method to model tissue-specific metabolic pathways. Their algorithm may help researchers find new therapeutic targets for cancer and other diseases.

10 Mar 2016

Renal risk factors for NA-treated HBV patients identified

A South Korean research team has identified several clinical and medical factors associated with renal function decline in patients with chronic hepatitis B virus infection treated with oral nucleos(t)ide analogues.

10 Mar 2016

Absence of PEMT enzyme leads to development of fatty liver disease and tumours in thin patients

Researchers observe protection against obesity and insulin resistance but at the cost of prominent fatty liver disease in mice lacking the PEMT enzyme and patients with low levels of PEMT.

7 Mar 2016

Inherited gene after black plague may help treat HIV patients co-infected with hepatitis C

The Black Death swept Europe in the 14th century eliminating up to half of the population but it left genetic clues that now may aid a University of Cincinnati researcher in treating HIV patients co-infected with hepatitis C using an anti-retroviral drug therapy.

7 Mar 2016

Routine stress adversely affects women’s heart

While the number of men dying from a heart attack has been constantly decreasing during the past twenty years, the fatal risk particularly in young women has increased significantly. Gender medicine has already demonstrated that women exhibit different symptoms. A new insight shows that stress in the daily routine has particularly adverse effects on the hearts of women. This was emphasised by Alexandra Kautzky-Willer, Professor for Gender Medicine of MedUni Vienna, on the occasion of the impending International Women's Day on 8 March 2016.

4 Mar 2016

P53 genetic variant heavily implicated in metabolism, new research finds

The study may also provide an evolutionary explanation for differences in populations living farther away from the Equator. Human ancestors may have undergone this change in R72 to promote energy storage in cold climates and during times of famine. However, in modern society, the need for this type of variant in our genes is unnecessary, leading instead to increased risk for obesity and type 2 diabetes. Obesity is also a risk factor for certain types of cancer, so these findings may also explain why the R72 variant of p53 might predispose certain people to cancer.

4 Mar 2016

Cardiac reprogramming could shrink heart scar tissue, improve patients' heart function

Patients with heart failure often have a buildup of scar tissue that leads to a gradual loss of heart function. In a new study published today in the journal Cell Stem Cell, researchers from the University of North Carolina School of Medicine report significant progress toward a novel approach that could shrink the amount of heart scar tissue while replenishing the supply of healthy heart muscle.

4 Mar 2016

Incidence of IBD much higher in Rhode Island

A study led by the Hasbro Children's Hospital Division of Pediatric Gastroenterology, Nutrition and Liver Diseases found that the incidence of inflammatory bowel disease (IBD) in Rhode Island is one of the highest ever reported in the United States and that IBD rates nationally are much higher than previously reported.

4 Mar 2016

MSU scientists identify new kind of stem cell that could advance regenerative medicine

Scientists at Michigan State University have discovered a new kind of stem cell, one that could lead to advances in regenerative medicine as well as offer new ways to study birth defects and other reproductive problems.

4 Mar 2016

Dietary broccoli may protect against liver cancer

Consumption of broccoli has increased in the United States over the last few decades as scientists have reported that eating the vegetable three to five times per week can lower the risk of many types of cancer including breast, prostate, and colon cancers.

4 Mar 2016

Modified protein appears to reverse liver fibrosis, cirrhosis in rats

A protein modified to increase the amount of time it circulates in the bloodstream appears to reverse liver fibrosis and cirrhosis in rats, according to results of a study led by Johns Hopkins researchers.

3 Mar 2016

Common blood test could help predict risk of second stroke

A new discovery about ischemic stroke may allow to doctors to predict a patient's risk of having a second stroke using a commonly performed blood test and their genetic profile.

3 Mar 2016

Liver News and Research

FDA approves Xalkori (crizotinib) to treat patients with ROS-1 positive NSCLC

Lots of 'good' cholesterol may be bad

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

Gallbladder removal surgeries now becomes safer with new imaging procedure

Scientists map biological networks of genes to gain new insights on disease mechanisms

Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

Springing forward one hour may lead to increased heart attack risk

Is the global diet getting sweeter? An interview with Professor Barry Popkin

Bioengineers introduce CORDA algorithm to find new therapeutic targets for cancer

Renal risk factors for NA-treated HBV patients identified

Absence of PEMT enzyme leads to development of fatty liver disease and tumours in thin patients

Inherited gene after black plague may help treat HIV patients co-infected with hepatitis C

Routine stress adversely affects women’s heart

P53 genetic variant heavily implicated in metabolism, new research finds

Cardiac reprogramming could shrink heart scar tissue, improve patients' heart function

Incidence of IBD much higher in Rhode Island

MSU scientists identify new kind of stem cell that could advance regenerative medicine

Dietary broccoli may protect against liver cancer

Modified protein appears to reverse liver fibrosis, cirrhosis in rats

Common blood test could help predict risk of second stroke

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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