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UT Southwestern researchers discover protein that leads to brain cell death during stroke

One particular protein is the final executioner of events that result in the death of brain cells during stroke, researchers from UT Southwestern Medical Center and their collaborators report. This finding could ultimately lead to new ways to protect against brain damage.

7 Oct 2016

Virginia Tech scientists solve structure of enzyme that deactivates important antibiotic

A popular antibiotic called rifampicin, used to treat tuberculosis, leprosy, and Legionnaire's disease, is becoming less effective as the bacteria that cause the diseases develop more resistance.

7 Oct 2016

Researchers explain why explain why some tumors recur after immunotherapy

Immunotherapy is a new and highly promising form of treatment for cancer. In many patients, however, tumors recur after immunotherapy.

7 Oct 2016

Added benefit not proven for melanoma drug, IQWiG finds

Talimogene laherparepvec has been approved since December 2015 for adults with advanced melanoma.

7 Oct 2016

Johns Hopkins researchers identify protein that triggers brain cell death from strokes and injuries

Despite their different triggers, the same molecular chain of events appears to be responsible for brain cell death from strokes, injuries and even such neurodegenerative diseases as Alzheimer's.

7 Oct 2016

TUM scientists shed new light on metastases in the liver at early stage of pancreatic cancer

Pancreatic cancer is an exceptionally aggressive type of cancer. Frequently, metastases already start to grow in other organs, particularly often in the liver, before the original tumor was even detected.

7 Oct 2016

Aggressive neuroblastoma contains specific protein not found in benign forms of cancer

Aggressive forms of neuroblastoma contain a specific protein in their cells' nuclei that is not found in the nuclei of more benign forms of the cancer, and the discovery, made through research from the University of Rochester Medical Center, could lead to new forms of targeted therapy.

6 Oct 2016

Scientists report early-stage development of potential nerve agent antidote

Nerve agents are molecular weapons that invade the body and sabotage part of the nervous system, causing horrific symptoms and sometimes death within minutes. Few antidotes exist, and those that do must be administered soon after an attack.

5 Oct 2016

JAK inhibitors show promise in restoring hair growth in patients with alopecia areata

Seventy-five percent of patients with moderate to severe alopecia areata--an autoimmune disease that causes patchy, and less frequently, total hair loss--had significant hair regrowth after treatment with ruxolitinib, reported researchers from Columbia University Medical Center. By the end of their treatment, average hair regrowth was 92 percent.

5 Oct 2016

Researchers discover how appetite is controlled and influenced by the brain

Researchers from Daegu Gyeongbuk Institute of Science and Technology in Korea have uncovered the mechanisms behind the enzyme that controls our appetite in response to low glucose availability in the brain.

5 Oct 2016

BUSM scientists map active human apoptosome to provide better understanding of cell death

Programmed cell death, or apoptosis, plays a central role in the maintenance of human health by providing a line of defense against unrestricted cell growth that occurs in many cancers and AIDS as well as in neurodegenerative diseases and stroke.

4 Oct 2016

Study shows how common intestinal microbe protects the gut from attack by harmful bacteria

Antibiotics save millions of lives. But their tendency to kill helpful and harmful bacteria alike, coupled with the growing problem of antibiotic resistance, means that they are not without their downside.

4 Oct 2016

UTA research opens new doors for treatment of autoimmune diseases

Biologists at The University of Texas at Arlington have demonstrated that removing water molecules can deactivate caspase-3 enzymes, which opens new doors for treatment of autoimmune diseases like arthritis, which have been linked to overactive enzymes.

4 Oct 2016

HDAC inhibitors show potential to eliminate breast and ovarian cancer stem cells

A group of researchers, led by scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, has shown that histone deacetylase (HDAC) inhibitors have the potential to eliminate stubborn reservoirs of breast and ovarian cancer stem cells (CSCs).

4 Oct 2016

Enzyme News and Research

UT Southwestern researchers discover protein that leads to brain cell death during stroke

Virginia Tech scientists solve structure of enzyme that deactivates important antibiotic

Researchers explain why explain why some tumors recur after immunotherapy

Added benefit not proven for melanoma drug, IQWiG finds

Johns Hopkins researchers identify protein that triggers brain cell death from strokes and injuries

TUM scientists shed new light on metastases in the liver at early stage of pancreatic cancer

Aggressive neuroblastoma contains specific protein not found in benign forms of cancer

Scientists report early-stage development of potential nerve agent antidote

JAK inhibitors show promise in restoring hair growth in patients with alopecia areata

Researchers discover how appetite is controlled and influenced by the brain

BUSM scientists map active human apoptosome to provide better understanding of cell death

Study shows how common intestinal microbe protects the gut from attack by harmful bacteria

UTA research opens new doors for treatment of autoimmune diseases

HDAC inhibitors show potential to eliminate breast and ovarian cancer stem cells

Blocking production of key receptor may reduce effects of cigarette smoke toxicity, study finds

ACMSD enzyme could become key target for new drugs aimed at preventing suicide

Study suggests targeting UNG enzyme may help treat non-Hodgkin's lymphoma

Research findings provide new clues to treat metabolic diseases

New TSRI study offers surprising twist on how life began on Earth

TUM scientists discover molecular mechanism responsible for liver metastases at early stage

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

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