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Study on the immunogenicity of monkeypox virus messenger ribonucleic acid-based vaccine candidates

In a new study, researchers developed two monkeypox (MPX) virus (MPXV) quadrivalent messenger ribonucleic acid (mRNA) vaccines, mRNA-A-lipid nanoparticle (LNP) and mRNA-B-LNP.

28 Nov 2022

Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Mutations of BRCA1 and BRCA2 genes, which are inherited by 1 in 400 and 1 in 800 people respectively, significantly increase the risk of certain cancers such as ovarian, breast, pancreatic and prostate cancer.

28 Nov 2022

Molecular and cellular similarities identified in the brains of SARS-CoV-2 and Alzheimer's disease patients

Researchers evaluated neuro-pathophysiological consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, especially the post-acute sequelae of SARS-CoV-2 (PASC) in Alzheimer’s disease (AD) patients.

28 Nov 2022

Characterization of bat viromes reveals the co-infection, spillover, and emergence risk of several zoonotic viruses

Researchers characterized the mammal-infecting viruses in 149 bats, representing six genera and 15 species, sampled from Yunnan province, China using an unbiased meta-transcriptomics approach.

28 Nov 2022

The frequency, magnitude, and longevity of natural antibody responses against nine P. vivax vaccine candidate proteins

A new study aimed to evaluate the magnitude, longevity, and prevalence of naturally acquired IgG antibody responses against 9 P. vivax vaccine candidate antigens in patients with acute vivax malaria and were followed up for 180 days.

28 Nov 2022

Cryo-electron tomography helps visualize platelet deformation due to SARS-CoV-2 spike protein

Researchers used cellular cryo-electron tomography (cryo-ET) to demonstrate the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in coronavirus disease 2019 (COVID-19)-triggered severe coagulopathies.

28 Nov 2022

Possibility of the first fluid biomarker that reflects brain pathology in primary tauopathies

Addressing this gap in research, a recent Nature Medicine study hypothesized that 4R isoform-specific MTBR-tau species accumulate in the patient’s brain of specific subtypes of 4R tauopathies.

28 Nov 2022

Glycan signatures in rheumatic diseases and their associated functional implications

A new paper examines the understanding of glycosylation in an array of rheumatic diseases and indicates the potential for therapeutic interventions using the same mechanism.

28 Nov 2022

Should older seniors risk major surgery? New research offers guidance

Nearly 1 in 7 older adults die within a year of undergoing major surgery, according to an important new study that sheds much-needed light on the risks seniors face when having invasive procedures.

28 Nov 2022

New chemical probe can selectively inhibit human COQ8A protein in cells

Inhibition of the COQ8 protein could be beneficial in the treatment of diseases such as cancer. COQ8 is needed for the biosynthesis of coenzyme Q, also known as ubiquinone.

28 Nov 2022

Flavonoids with potential to fight allergies and inflammation

In a recent study published in the Biomedicine & Pharmacotherapy journal, researchers explored the anti-allergic and anti-inflammatory properties of flavonoids.

28 Nov 2022

Are nasal-spray vaccines the solution to respiratory infectious diseases?

A recent study published in the journal Trends in Molecular Medicine reviewed the current efforts in developing nasal vaccines, delivery systems, and clinical applications for preventing respiratory illnesses.

28 Nov 2022

Memory B and T cells responses differ when induced by SARS-CoV-2 infections or booster vaccinations

In a recent study published in The Journal of Immunology, a team of researchers from Japan examined the memory B and T cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein after the booster dose of the coronavirus disease 2019 (COVID-19) messenger ribonucleic acid (mRNA) vaccine BNT162b2.

27 Nov 2022

Nanoparticles displaying SARS-CoV-1 and SARS-CoV-2 spikes induce broad antibody responses in animal model

A recent study published in the journal iScience reported that nanoparticles (NPs) co-displaying spike proteins from different sarbecoviruses improve the breadth of neutralizing responses.

27 Nov 2022

The distinct pathophysiology of ‘SuperAger’ brains

Superagers are adults over the age of 80 who have a superior memory capacity that resembles that of middle-aged adults.

27 Nov 2022

Klotho protein levels protect against cognitive decline in Alzheimer patients

Researchers compare Klotho protein levels of healthy individuals and patients diagnosed with different stages of Alzheimer’s disease.

27 Nov 2022

MicroRNAs play a key role in the development of complex brains

Cephalopods like octopuses, squids and cuttlefish are highly intelligent animals with complex nervous systems.

25 Nov 2022

Researchers discover a new function of CRISPR/Cas9 gene scissors

For several years now, the CRISPR/Cas9 gene scissors have been causing a sensation in science and medicine.

25 Nov 2022

Multivalent mRNA-based vaccine may serve as a preventative measure against future flu pandemics

An experimental mRNA-based vaccine against all 20 known subtypes of influenza virus provided broad protection from otherwise lethal flu strains in initial tests, and thus might serve one day as a general preventative measure against future flu pandemics, according to researchers from the Perelman School of Medicine at the University of Pennsylvania.

25 Nov 2022

Scientists investigate the evolutionary origin of SARS-CoV-2 using recombination-aware phylogenetic analysis

A study has employed Bacter to identify recombination events with the RBD regions of the Sarbecovirus genome.

25 Nov 2022

Protein C News and Research

Study on the immunogenicity of monkeypox virus messenger ribonucleic acid-based vaccine candidates

Researchers highlight the importance of localizing BRCA gene mutations for better ovarian cancer treatment

Molecular and cellular similarities identified in the brains of SARS-CoV-2 and Alzheimer's disease patients

Characterization of bat viromes reveals the co-infection, spillover, and emergence risk of several zoonotic viruses

The frequency, magnitude, and longevity of natural antibody responses against nine P. vivax vaccine candidate proteins

Cryo-electron tomography helps visualize platelet deformation due to SARS-CoV-2 spike protein

Possibility of the first fluid biomarker that reflects brain pathology in primary tauopathies

Glycan signatures in rheumatic diseases and their associated functional implications

Should older seniors risk major surgery? New research offers guidance

New chemical probe can selectively inhibit human COQ8A protein in cells

Flavonoids with potential to fight allergies and inflammation

Are nasal-spray vaccines the solution to respiratory infectious diseases?

Memory B and T cells responses differ when induced by SARS-CoV-2 infections or booster vaccinations

Nanoparticles displaying SARS-CoV-1 and SARS-CoV-2 spikes induce broad antibody responses in animal model

The distinct pathophysiology of ‘SuperAger’ brains

Klotho protein levels protect against cognitive decline in Alzheimer patients

MicroRNAs play a key role in the development of complex brains

Researchers discover a new function of CRISPR/Cas9 gene scissors

Multivalent mRNA-based vaccine may serve as a preventative measure against future flu pandemics

Scientists investigate the evolutionary origin of SARS-CoV-2 using recombination-aware phylogenetic analysis

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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