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Combination antibody therapies retain potency against SARS-CoV-2 variants, FDA / HHS research

Researchers in the United States have conducted a study showing that while variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can compromise the effectiveness of single therapeutic antibodies at preventing severe coronavirus disease 2019 (COVID-19), many combination antibody products remain potent against the variants.

21 Jul 2021

Scientists seek to block pathogen’s most reliable weapon to cause severe malaria

The parasites that cause severe malaria are well-known for the sinister ways they infect humans, but new research may lead to drugs that could block one of their most reliable weapons: interference with the immune response.

21 Jul 2021

Intestinal organoids demonstrate variability in SARS-CoV-2 susceptibility

Three-dimensional organoid structures grown in the lab allow deeper, almost in situ investigation of a biological system, without the use of living animals. In a paper recently uploaded to the preprint server bioRxiv*, organoids generated from human specimens are utilized to investigate the way in which SARS-CoV-2 interacts with the numerous cells of the intestinal epithelium, finding great heterogeneity in the susceptibility of the organoids and the cells within to infection.

21 Jul 2021

Potent nasal vaccine protects non-human primates from SARS-CoV-2

A team of US-based scientists has recently demonstrated the efficacy of a live attenuated, recombinant coronavirus disease 2019 (COVID-19) vaccine candidate currently under phase I clinical trial as a single-dose intranasal vaccine.

20 Jul 2021

Maternal fecal transplant may help restore gut microbiota in newborns with diabetes risk

Newborns at risk for Type 1 diabetes because they were given antibiotics may have their gut microorganisms restored with a maternal fecal transplant, according to a Rutgers study.

20 Jul 2021

MET amplification identified as a potentially actionable driver for non-small cell lung cancer

A study led by D. Ross Camidge, MD, PhD, director of thoracic oncology at the University of Colorado School of Medicine and CU Cancer Center member, has helped to define MET amplification as a rare but potentially actionable driver for non-small cell lung cancer (NSCLC).

20 Jul 2021

UMD receives funding to enhance quality of pork production through improved muscle growth in pigs

The University of Maryland received funding from the United States Department of Agriculture National Institute of Food and Agriculture to enhance the overall quality and efficiency of pork production through improved muscle growth in pigs.

20 Jul 2021

Child with Bachmann-Bupp Syndrome successfully treated in just 16 months

Diagnosing a rare medical condition is difficult. Identifying a treatment for it can take years of trial and error. In a serendipitous intersection of research expertise, an ill patient in this case a child and innovative technology, Bachmann-Bupp Syndrome has gone from a list of symptoms to a successful treatment in just 16 months.

20 Jul 2021

Protein consumption at breakfast can increase muscle size and function, finds study

Proteins constitute an essential dietary component that help in the growth and repair of the body. Composed of long chains of amino acids, proteins promote the growth of skeletal muscles, the group of muscles that help us move.

20 Jul 2021

A path to treat currently untreatable cases of cystic fibrosis is clearly achievable, study suggests

An experimental drug reported in Nature Communications suggests that a "path is clearly achievable" to treat currently untreatable cases of cystic fibrosis disease caused by nonsense mutations.

19 Jul 2021

Study elucidates the role of two isoforms of KRAS oncogenes

KRAS was one of the first oncogenes to be identified, a few decades ago. It is among the most common drivers of cancer and its mutations can be detected in around 25 per cent of human tumors.

19 Jul 2021

T cells can be engineered to fight tumors without succumbing to exhaustion

Fighting a tumor is a marathon, not a sprint. For cancer-fighting T cells, the race is sometimes just too long, and the T cells quit fighting. Researchers even have a name for this phenomenon: T cell exhaustion.

19 Jul 2021

New online tool launched to accelerate discoveries for reversing progressive hearing loss

Researchers at the University of Maryland School of Medicine launched a new online tool that could more quickly advance medical discoveries to reverse progressive hearing loss.

19 Jul 2021

Scientists deconstruct the protein-based machine responsible for SARS-CoV-2 replication

In February 2020, a trio of bio-imaging experts were sitting amiably around a dinner table at a scientific conference in Washington, D.C., when the conversation shifted to what was then a worrying viral epidemic in China.

19 Jul 2021

Study: Second dose of COVID-19 vaccine induces a powerful boost to the immune system

The second dose of a COVID-19 vaccine induces a powerful boost to a part of the immune system that provides broad antiviral protection, according to a study led by investigators at the Stanford University School of Medicine.

19 Jul 2021

Tissue-specific genetic interactions drive different types of cancer development

Why do alterations of certain genes cause cancer only in specific organs of the human body? Scientists at the German Cancer Consortium, the Technical University of Munich, and the University Medical Center Göttingen have now demonstrated that cells originating from different organs are differentially susceptible to activating mutations in cancer drivers: The same mutation in precursor cells of the pancreas or the bile duct leads to fundamental different outcomes.

19 Jul 2021

Research shows a direct link between SUV39H2 gene and autism spectrum disorders

New research from the RIKEN Center for Brain Science in Japan shows that a deficit in histone methylation could lead to the development of autism spectrum disorders (ASD).

16 Jul 2021

New algorithm can be a more effective way to analyze models of biological systems

From biochemical reactions that produce cancers, to the latest memes virally spreading across social media, simple actions can generate complex behaviors.

16 Jul 2021

Researchers identify novel disorder resulting from a mutation in AIOLOS protein

Primary immunodeficiencies, such as severe combined immunodeficiency disease (SCID), occur when the immune system does not work properly, leading to increased susceptibility to various infections, autoimmunity, and cancers.

16 Jul 2021

Study uncovers how force dynamics affect cells and living tissues

Researchers, led by Pere Roca-Cusachs at the Institute for Bioengineering of Catalonia (IBEC) discover how force dynamics affect cells, and living tissues. The results give an insight into the critical mechanical processes that occur in different diseases such as cancer.

16 Jul 2021

Genes News and Research

Combination antibody therapies retain potency against SARS-CoV-2 variants, FDA / HHS research

Scientists seek to block pathogen’s most reliable weapon to cause severe malaria

Intestinal organoids demonstrate variability in SARS-CoV-2 susceptibility

Potent nasal vaccine protects non-human primates from SARS-CoV-2

Maternal fecal transplant may help restore gut microbiota in newborns with diabetes risk

MET amplification identified as a potentially actionable driver for non-small cell lung cancer

UMD receives funding to enhance quality of pork production through improved muscle growth in pigs

Child with Bachmann-Bupp Syndrome successfully treated in just 16 months

Protein consumption at breakfast can increase muscle size and function, finds study

A path to treat currently untreatable cases of cystic fibrosis is clearly achievable, study suggests

Study elucidates the role of two isoforms of KRAS oncogenes

T cells can be engineered to fight tumors without succumbing to exhaustion

New online tool launched to accelerate discoveries for reversing progressive hearing loss

Scientists deconstruct the protein-based machine responsible for SARS-CoV-2 replication

Study: Second dose of COVID-19 vaccine induces a powerful boost to the immune system

Tissue-specific genetic interactions drive different types of cancer development

Research shows a direct link between SUV39H2 gene and autism spectrum disorders

New algorithm can be a more effective way to analyze models of biological systems

Researchers identify novel disorder resulting from a mutation in AIOLOS protein

Study uncovers how force dynamics affect cells and living tissues

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