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Researchers identify a bacterium with anti-SARS-CoV-2 activity in vitro: Dolosigranulum pigrum

As intensive efforts are on to counter the virus, a new study by an international team of researchers reports the unexpected success of a bacterium in modulating the immune response in the airway and protecting the cells against infection with this virus.

7 Jun 2021

Could sustained inflammation following mild to moderate COVID-19 be a driver of long COVID?

A new study describes the discovery of sustained though low-level rises in inflammatory mediators and immune cells, as well as the loss of some subsets of naïve un-activated cells. This may indicate a widespread though muted immune-mediated inflammatory response in these patients.

7 Jun 2021

The great promise of antiviral peptides against SARS-CoV-2

A new study, recently published in the journal Viruses, describes the impressive evidence for the role of antimicrobial peptidse (AMPs) in the treatment of COVID-19.

7 Jun 2021

Kawasaki disease in children has reduced during COVID-19 due to pandemic prevention efforts

The rate of Kawasaki disease in South Korea has substantially decreased during the COVID-19 pandemic, possibly due to pandemic prevention efforts, such as mask-wearing, hand-washing and physical distancing, according to new research published today in the American Heart Association's flagship journal Circulation.

7 Jun 2021

Accuracy of three COVID-sniffing dogs exceeds 85%

A team of scientists from Italy and Brazil has recently conducted a training program for sniffer dogs to detect coronavirus disease 2019 (COVID-19). They have trained the dogs to accurately sense COVID-19 specific volatile organic compounds in sweat samples collected from COVID-19 patients. The study is currently available on the medRxiv* preprint server.

7 Jun 2021

Researchers create cellular and spatial “atlas” of the choroid plexus during different life stages

Once viewed merely as a producer of the cerebrospinal fluid (CSF) bathing the brain and spinal cord, the choroid plexus is now known to be a key player in brain development and immunity.

7 Jun 2021

Vaccination against SARS-CoV-2 with a single dose skin patch

Researchers from Australia recently reported a high-density microarray patch used to deliver a SARS-CoV-2 spike subunit vaccine to the skin directly. They used a combination of a SARS-CoV-2 spike protein vaccine candidate and the high-density microarray patch (HD-MAP) vaccine delivery platform.

7 Jun 2021

Impact of maternal SARS-CoV-2 infection on neonatal immunology

Although extensive studies have been carried out on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and evidence exists that pregnant women are at elevated risk of severe COVID-19, the impact of maternal infection on the fetus is not clear. The majority of pregnant women infected with SARS-CoV-2 are asymptomatic or experience mild symptoms.

7 Jun 2021

COVID-19 symptoms in the feet

In a review paper recently uploaded to the Journal of Clinical Medicine by Jimenez-Cebrian et al. (May 19th, 2021), the clinical manifestations of COVID-19 in feet, in particular, are reviewed, finding that vascular, dermatological, and neurological symptoms have been widely reported.

6 Jun 2021

High baseline levels of inflammatory cytokines linked to thrombotic events in patients with COVID-19

In a recent open-access paper published in the Journal of Clinical Medicine, researchers from Iran and Germany show that high baseline levels of inflammatory cytokines measured during admission put patients with coronavirus disease (COVID-19) at increased risk of developing coagulopathy, thrombotic events – and even death.

6 Jun 2021

Standardizable assay detects T cell responses to SARS-CoV-2 infection

Researchers in the UK have developed a high-throughput standardizable assay that accurately detects T cell responses to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

6 Jun 2021

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

An interesting new bioRxiv* preprint reports the suppression of monocyte glycolysis and cytokine production when exposed to the virus, following pretreatment with the commonly used drug, metformin.

6 Jun 2021

Study finds molecular pathway that can explain how chronic kidney disease induces heart failure

According to the Global Burden of Disease Study 2017, close to nine percent of the global population lives with some form of chronic kidney disease, or CKD. Not only does the condition affect renal function, CKD has long been associated with increased risk of cardiovascular disease.

5 Jun 2021

Missing antibody molecule may predict disease severity in secondary dengue infection

A first encounter with the dengue virus typically causes very mild symptoms; however, a subsequent infection is a different story.

5 Jun 2021

Increasing a protein concentrated in brown fat may lower diabetes risk

Increasing a protein concentrated in brown fat appears to lower blood sugar, promote insulin sensitivity, and protect against fatty liver disease by remodeling white fat to a healthier state, a new study led by UT Southwestern scientists suggests.

5 Jun 2021

Weight loss drug Wegovy approved by FDA

The U.S. Food and Drug Administration (FDA) has approved Wegovy (semaglutide) injection (2.4 mg once weekly) as a chronic weight management treatment in obese or overweight adults with a weight-related condition (such as high blood pressure, type 2 diabetes, or high cholesterol), when used along with calorie restriction and physical activity. Wegovy, is a more potent version of Novo Nordisk's diabetes drug semaglutide.

4 Jun 2021

Inflammation News and Research

Researchers identify a bacterium with anti-SARS-CoV-2 activity in vitro: Dolosigranulum pigrum

Could sustained inflammation following mild to moderate COVID-19 be a driver of long COVID?

The great promise of antiviral peptides against SARS-CoV-2

Kawasaki disease in children has reduced during COVID-19 due to pandemic prevention efforts

Accuracy of three COVID-sniffing dogs exceeds 85%

Researchers create cellular and spatial “atlas” of the choroid plexus during different life stages

Vaccination against SARS-CoV-2 with a single dose skin patch

Impact of maternal SARS-CoV-2 infection on neonatal immunology

COVID-19 symptoms in the feet

High baseline levels of inflammatory cytokines linked to thrombotic events in patients with COVID-19

Standardizable assay detects T cell responses to SARS-CoV-2 infection

Metformin potently inhibits SARS-CoV-2-induced cytokine release in monocytes

Study finds molecular pathway that can explain how chronic kidney disease induces heart failure

Missing antibody molecule may predict disease severity in secondary dengue infection

Increasing a protein concentrated in brown fat may lower diabetes risk

Weight loss drug Wegovy approved by FDA

Maternal SARS-CoV-2 infection imprints immune response in the newborn

Mental health effects common among mild and severe cases of COVID-19

Potential transmission for Kawasaki disease unexpectedly uncovered due to COVID-19

New scientific evidence supports the health benefits of superfoods

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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