Mutation News and Research

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New study reveals how cancer becomes drug resistant over time

Like a colony of bacteria or species of animals, cancer cells within a tumor must evolve to survive. A dose of chemotherapy may kill hundreds of thousands of cancer cells, for example, but a single cell with a unique mutation can survive and quickly generate a new batch of drug-resistant cells, making cancer hard to combat.

21 Oct 2014

Janssen announces submission of IMBRUVICA sNDA to FDA for WM treatment

Janssen Research & Development, LLC today announced the submission of a supplemental New Drug Application (sNDA) for IMBRUVICA (ibrutinib) to the U.S. Food and Drug Administration by its strategic partner Pharmacyclics, Inc.

20 Oct 2014

Whole exome sequencing can assist in early diagnosis of various disorders

Approximately one-fourth of the 3,386 patients whose DNA was submitted for clinical whole exome testing received a diagnosis related to a known genetic disease, often ending a long search for answers for them and their parents, said researchers from the Baylor College of Medicine departments of molecular and human genetics and pediatrics and the Baylor Human Genome Sequencing Center and the University of Texas Health Science Center at Houston.

20 Oct 2014

Genetic changes in blood cells of older people linked to lymphoma, leukemia

At least 2 percent of people over age 40 and 5 percent of people over 70 have mutations linked to leukemia and lymphoma in their blood cells, according to new research at Washington University School of Medicine in St. Louis.

20 Oct 2014

Longer Looks: An Alabama Judge's Dismantling Of Roe V. Wade; The Mystery Of Enterovirus; Mutating Ebola

In the nine years Parker has now served on the court, he has made the most of his opportunities. Child custody disputes, for instance, have made good occasions to expound on the role of religion in parental rights.

17 Oct 2014

Researchers identify novel method to develop personalized vaccines for ovarian cancer

Researchers at the University of Connecticut have found a new way to identify protein mutations in cancer cells. The novel method is being used to develop personalized vaccines to treat patients with ovarian cancer.

16 Oct 2014

New oral biologic medication successfully treats precancerous intestinal inflammation

An oral biologic medication has successfully treated chronic, precancerous inflammation in the intestine, according to results of an animal study authored by an MD/PhD student in the University at Buffalo School of Medicine and Biomedical Sciences.

16 Oct 2014

Half-day educational program can help educate women on side effects of cancer prevention surgery

More women are having ovary-removing surgery as a cancer prevention measure, but many are often unaware of sexual or psychological side effects of the procedure. A new study by researchers at Dana-Farber Cancer Institute shows a half-day educational program can help successfully deal with these issues by educating women on how to address them.

16 Oct 2014

New mutations in cat genome identified as causes of human eye diseases

Researchers from the University of Missouri and the 99 Lives Cat Genome Sequencing Initiative today announced groundbreaking discoveries of novel mutations in the cat genome found to correlate to two human eye diseases, retinitis pigmentosa and Leber's Congenital Amaurosis.

16 Oct 2014

Study: Tbx5 protein contributes to formation of epicardium, pericardium, coronary vessels

Congenital heart defects are the most common birth defect, affecting 8 out of every 1,000 newborns according to the National Heart, Lung and Blood Institute. In the U.S., more than 35,000 babies are born annually with some sort of heart defect.

16 Oct 2014

Statement on Ebola epidemic

The Ebola virus is spreading rapidly and to an unexpected extent. The outbreak does not follow the patterns experienced in the past and the virus shows a new disease dynamic in regions, where it has never been recorded before. For this reason, the German National Academy of Sciences Leopoldina, acatech – the German Academy of Science and Engineering, and the Union of the German Academies of Sciences and Humanities have presented a statement on the Ebola epidemic today.

16 Oct 2014

Views on Ebola: Try to keep 'an even keel'; who's in charge of fighting a pandemic?

Understandably, the specter of such a dangerous disease in the United States has bred fear. But it is remarkable how some public figures are inflaming that fear. Commentator Rush Limbaugh took flight on Tuesday, saying on the radio that "I don't think anybody involved with Ebola knows what they're doing. I don't care if it's the WHO or the Centers for Disease Control, I don't think anybody knows what they're doing." This was an unfounded rant that can only deepen public disquiet.

16 Oct 2014

Research on zebrafish helps identify cause of unknown genetic disorder

Research in zebrafish has helped identify the cause of an unknown genetic disorder affecting a boy and two of his uncles, scientists report in an article published October 14 in the journal GENETICS.

16 Oct 2014

Sheffield researchers find vital new evidence on how to reverse effects of Parkinson's mutation

Researchers from the University of Sheffield have found vital new evidence on how to target and reverse the effects caused by one of the most common genetic causes of Parkinson's.

16 Oct 2014

Researchers define the process of Parkinson's disease using genetic mouse model

Parkinson's Disease is the second most common neurodegenerative disorder. In Germany alone, almost half a million people are affected. The focus of the disease is the progressive degeneration of dopamine-producing nerve cells in a certain region of the midbrain, the substantia nigra. Misfolded proteins are the cause. Until recently, it was unclear why damage is confined to specific nerve cells.

16 Oct 2014

Colorado University to limit student work hours -- partly to ease health law coverage requirements

The University of Colorado at Boulder is limiting student employee hours to 25 a week during spring and fall semesters in response to Affordable Care Act provisions, and other CU campuses are doing the same. In a newsletter to students, CU-Boulder said the act - which requires employers to provide health insurance to employees working 30 or more hours per week, or pay fines - was the catalyst for the policy change but not the sole reason. "Not only does the policy support degree attainment as the student's primary focus, it will help assist the campus in achieving chancellor (Phil) DiStefano's initiative of increasing the six-year graduation rate," the newsletter said.

16 Oct 2014

Penn Medicine announces recipients of new Basser External Research Grant Program

The University of Pennsylvania's Basser Research Center for BRCA has announced $6.9 million to research teams both at Penn and at five other institutions across the United States, aimed at advancing the care of patients living with BRCA1 and BRCA2 mutations through multi-disciplinary collaboration.

15 Oct 2014

MU research finds that neurons actively 'fine tune' for electrical imbalances at genetic level

Neurons are electrically charged cells, located in the nervous system, that interpret and transmit information using electrical and chemical signals. Now, researchers at the University of Missouri have determined that individual neurons can react differently to electrical signals at the molecular level and in different ways—even among neurons of the same type.

15 Oct 2014

OGT's new CytoSure Medical Research Exome Array to be launched at ASHG 2014

Oxford Gene Technology, The Molecular Genetics Company, will launch its CytoSure Medical Research Exome Array at the 64th Annual Meeting of the American Society of Human Genetics 2014, taking place in San Diego on October 18-22.

From Oxford Gene Technology 15 Oct 2014

Research findings point toward new therapeutic target for aggressive breast cancer

One of the first-known oncogenes has a protein partner that helps breast cancer proliferate and when it's blocked, so is the cancer, scientists report.

15 Oct 2014

Mutation News and Research

New study reveals how cancer becomes drug resistant over time

Janssen announces submission of IMBRUVICA sNDA to FDA for WM treatment

Whole exome sequencing can assist in early diagnosis of various disorders

Genetic changes in blood cells of older people linked to lymphoma, leukemia

Longer Looks: An Alabama Judge's Dismantling Of Roe V. Wade; The Mystery Of Enterovirus; Mutating Ebola

Researchers identify novel method to develop personalized vaccines for ovarian cancer

New oral biologic medication successfully treats precancerous intestinal inflammation

Half-day educational program can help educate women on side effects of cancer prevention surgery

New mutations in cat genome identified as causes of human eye diseases

Study: Tbx5 protein contributes to formation of epicardium, pericardium, coronary vessels

Statement on Ebola epidemic

Views on Ebola: Try to keep 'an even keel'; who's in charge of fighting a pandemic?

Research on zebrafish helps identify cause of unknown genetic disorder

Sheffield researchers find vital new evidence on how to reverse effects of Parkinson's mutation

Researchers define the process of Parkinson's disease using genetic mouse model

Colorado University to limit student work hours -- partly to ease health law coverage requirements

Penn Medicine announces recipients of new Basser External Research Grant Program

MU research finds that neurons actively 'fine tune' for electrical imbalances at genetic level

OGT's new CytoSure Medical Research Exome Array to be launched at ASHG 2014

Research findings point toward new therapeutic target for aggressive breast cancer

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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